Although disasters can occur anywhere, certain types of disasters are more likely to have more effects on some buildings than others, especially on those in urban areas. Buildings in Lagos have had nasty experiences from both natural and artificial disasters, claiming lives and properties in the past. This study aims at evaluating the disaster risks, vulnerabilities and response strategies in the high rise buildings in Lagos municipality. Structured questionnaire was administered to building owners, estate managers and disaster managers who manage the high rise buildings. The information obtained was supplemented by personal interviews conducted with tenants and rescue organizations. The study identified collapse of building, fire out break, and communication and power failure as the most likely potential disasters, power failure and collapse had the highest severity of impact, and the degree of preparedness achieved to confront the disasters was below satisfaction. However, the specific status of the response strategies was as expected, but there was room for improvements. The potential disasters were natural, human and environmental and the most vulnerable sectors were other properties rather than the high rise buildings themselves. The magnitude of risk levels could be contained with the level of response strategies already achieved if coordinated.