Impact of luteinizing hormone administration on gonadotropin-releasing hormone antagonist cycles: an age-adjusted analysis

Bosch, Ernesto; Labarta, Elena; Crespo, Juana; Simón, Carlos; Remohı́, José; Pellicer, António

doi:10.1016/j.fertnstert.2010.10.021

Cited by 126 publications

(153 citation statements)

References 31 publications

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“…In keeping with our results, Bosch et al [1] recently showed an improved implantation rate and a trend towards improved pregnancy rate. However, patients in the rFSHonly group were started at a higher dose of rFSH than those in the rFSH + rLH group, instead of the usual practice of tailoring an appropriate starting dose to the individual patient.…”

Section: Discussionsupporting

confidence: 93%

“…This automatic lower starting dose of rFSH when rLH supplementation was used may have mitigated beneficial effects from the rLH supplementation. Interestingly Bosch [1] found that benefits associated with LH supplementation were only for patients greater than 35 years of age. Although our present study was not powered to find subgroup differences, a trend was seen for improved outcomes with rLH supplementation in both patients <35 years and those ≥35 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…Specific populations that have been suggested to benefit include patients greater than 35 years of age [1,13,14,16], suboptimal responders to ovarian stimulation ( [6,12,16]) and those undergoing specifically a GnRH antagonist cycle [2] or GnRH agonist cycles [9].…”

Section: Introductionmentioning

confidence: 99%

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Improved pregnancy rates with luteinizing hormone supplementation in patients undergoing ovarian stimulation for IVF

Paterson

Foong

Greene

2012

J Assist Reprod Genet

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Introduction Luteinizing hormone (LH) is believed to play a role in follicle maturation during the natural cycle. However, the need for co-treatment with recombinant LH (rLH) for controlled ovarian stimulation is controversial. Purpose The primary objective of our study was to determine if pregnancy rates are improved when rLH is used in addition to rFSH for ovarian stimulation. Secondary outcomes were fertilization rate, implantation rate and live birth rate. Methods A retrospective cohort study was performed of 1565 IVF or ICSI cycles. Outcomes were compared between ovarian stimulation cycles from 2007 when rLH and rFSH was used (n0765) to 2006 when rFSH only was used (n-800). Results Improved outcomes were found for rLH + rFSH versus rFSH alone for; pregnancy rate (61% and 54% respectively, p00.006), live birth rate (49% and 42% respectively, P 00.01), fertilization rate (74% versus 72% respectively, p00.04 and implantation rate (41% versus 37% respectively, p00.03).Conclusions Our large retrospective cohort study showed an improved pregnancy rate and live birth rate with rLH supplementation. This was associated with an improved fertilization and implantation rate and therefore may reflect an improvement in oocyte quality and/or uterine receptivity.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Improved pregnancy rates with luteinizing hormone supplementation in patients undergoing ovarian stimulation for IVF

Paterson

Foong

Greene

2012

J Assist Reprod Genet

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“…A number of authors reported that older patients and women with inadequate response to FSH get the most benefit from LH supplementation [15,[36][37][38][39]. The present pilot study demonstrated that in a standard long protocol in poor responders, adding late follicular hCG to rFSH in a dose of 100 IU is associated with higher total number of retrieved oocytes than control group which received rFSH alone.…”

Section: Variablesupporting

confidence: 47%

Efficacy of low dose hCG on oocyte maturity for ovarian stimulation in poor responder women undergoing intracytoplasmic sperm injection cycle: a randomized controlled trial

Madani

Yeganeh

Khodabakhshi

et al. 2012

J Assist Reprod Genet

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Purpose To investigate the effect of late follicular administration of low dose hCG on oocyte maturity in poor responding women undergoing intracytoplasmic sperm injection (ICSI). Materials and methods This prospective randomized pilot trial was performed on 73 poor responders undergoing ICSI, in Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran. All eligible patients underwent a GnRH-a long protocol and were randomly allocated into three study groups for ovarian stimulation: groupA received recombinant FSH alone, group B received recombinant FSH supplemented by 100 IU hCG. Group C received recombinant FSH supplemented by 200 IU hCG. The main endpoint was the number of metaphase II oocytes retrieved. Results Of 78 poor responding patients entered to this study, 73 women were considered eligible for enrolment. Of these, 26 women were allocated to receive only recombinant FSH, 24 patients allocated to receive recombinant FSH and 100 IU hCG and 23 patients were assigned to receive recombinant FSH and 200 IU hCG. Number of oocytes retrieved were significantly higher in group B compared to group A (6.5±3.3 versus 4.0±2.3; P0.03). Other cycle and clinical outcomes were comparable between three groups. Conclusions The present study demonstrated that adding 100 IU hCG to rFSH in a GnRH agonist cycle in poor responders improve response to stimulation whereas the number of metaphase II oocytes remains comparable between groups.

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“…25,27 Yine 2011 yılında Bosch ve ark.nın GnRH antagonist protokol uygulanan olgular üze-rinde yaptıkları çalışmada 36-39 yaş grubundaki olgularda r-LH eklenmesinin implantasyon oranını ve devam eden gebelik oranlarını artırdığı, 36 yaşın altındaki olguların LH desteğinden fayda görme-diklerini bildirmişlerdir. 28 Sonuç olarak, KOS'ta seçilmemiş olgularda r-LH eklenmesinin faydası olmadığı görülmektedir. Ancak, ovaryan stimülasyona kötü yanıtı olanlarda ve 35 yaş üstü kadınlarda muhtemel faydası olabilir.…”

Section: Gonadotropi̇n Seçi̇mi̇unclassified

Controlled Ovarian Stimulation in IVF Cycles

Gürgan¹,

Gülerman²,

Özyer³

2017

TJRMS

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42n vitro fertilizasyon (IVF) sonrası ilk başarılı doğum, spontan ovulatuar siklusta tek bir oosit elde edilip tek embryo transferi yapılmasıyla sağlanmıştır. Ancak bu yöntemin başarı oranı dü-şüktür ve günümüzde klinisyenler çok sayıda follikülün senkron gelişimini sağlayacak ovaryan stimülasyon stratejilerinin kullanımını benimsemişlerdir. Kontrollü ovaryan stimülasyon (KOS), IVF tedavisi dahilinde overlerden en ideal sayı ve kalitede oosit elde etmek amacı ile aynı siklusta çok sayıda follikülün geliştirilmesidir. 1970'li yıllardaki ilk uygulamalardan itibaren KOS, IVF'in temel basamaklarından birini oluşturmaktadır. Oosit kalitesini ve canlı doğum oranlarını artırmak, düşük over rezervi olan hastalarda over yanıtını iyileştir-mek ve ovaryan hiperstimülasyon riskini azaltmak amacıyla çeşitli KOS protokolleri geliştirilmiştir. A An na ah h t ta ar r K Ke e l li i m me e l le er r: : İn vitro fertilizasyon; kontrollü ovaryan stimülasyon; protokol A AB BS S T TR RA AC CT T After the first live birth through a natural cycle in vitro fertilization (IVF) trial in 1978, advances in assisted reproductive techniques (ART) have been rapidly proceeded. Since then, more than 5 million pregnancies have been achieved worldwide by IVF and other modified techniques generally named as ART. As the experience and the success rates have increased, the indications for ART also expands. With the advances in reproductive biology, laboratory and pharmaceutical sciences, there is increasing attention on the importance of controlled ovarian stimulation (COS) to the IVF outcomes. Individualized COS (iCOS ) practices will improve IVF outcomes and safety issues. The aim of this review is to go through the fundamentals of COS and its best practices in ART.

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Impact of luteinizing hormone administration on gonadotropin-releasing hormone antagonist cycles: an age-adjusted analysis

Cited by 126 publications

References 31 publications

Improved pregnancy rates with luteinizing hormone supplementation in patients undergoing ovarian stimulation for IVF

Improved pregnancy rates with luteinizing hormone supplementation in patients undergoing ovarian stimulation for IVF

Efficacy of low dose hCG on oocyte maturity for ovarian stimulation in poor responder women undergoing intracytoplasmic sperm injection cycle: a randomized controlled trial

Controlled Ovarian Stimulation in IVF Cycles

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