Impact of MAGE-A antigens on taxane response in oral squamous cell carcinoma

Müller‐Richter, Urs; Dowejko, Albert; Driemel, Oliver; Reuther, T.; Reichert, Torsten E.; Kübler, Alexander C.

doi:10.3892/ol_00000033

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…This difference in expression might represent a reliable tool for the prognosis of OSCC. Moreover, a significantly worse response to the chemotherapeutics docetaxel and paclitaxel occurred for tumors that expressed MAGE-A4, similar to the findings reported by Müller-Richter et al (48). For MAGE-A5, significant results were obtained in general and for the tumor center.…”

Section: Discussionsupporting

confidence: 86%

Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma

et al. 2016

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MAGE-A proteins are highly expressed in oral squamous cell carcinoma (OSCC) and are promising targets for cancer immunotherapy. This study examined the presence of MAGE-A expression within the tumor center (TC) and tumor invasive front (TIF) and evaluated its relationship to poor prognosis. The expression rate of each MAGE-A subtype, A1-A12, was examined in 68 OSCCs at the TIF and TC. Slides (1-µm) of tissue microarrays (diameter =0.6 mm) were immunohistochemically stained, and the findings were correlated to clinical data. Approximately 95% of the tumors had MAGE-A expression. Higher expression in the TC was shown significantly for MAGE-A1, -A5, -A6, -A9 and -A12 (P<0.05). MAGE-A2 and -A3 exhibited the opposite behavior (not significant, P>0.05). Age, tumor size, grade and survival time were not associated with the expression of certain MAGE-A subgroups. When expression in the whole tumor tissue was considered, only MAGE-A1 was expressed at a significantly higher rate in male patients (P=0.034). At the TIF, MAGE-A9 and the UICC disease stage were significantly correlated (P=0.0263), and MAGE-A6 and the UICC disease stage exhibited a strong trend (P=0.0596). The expression of MAGE-A3, -A4, -A5, -A9 and -A11 was significantly associated with lymph node metastasis, while MAGE-A4 was expressed in all regions of the tumors (TIF and TC). This study showed that higher expression of most MAGE-A antigens occurred at the TC rather than at the TIF. MAGE‑A1, -A3, -A4, -A5, -A9 and -A11 were significantly associated with clinically advanced stages of disease and seem to be of particular interest.

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Section: Discussionsupporting

confidence: 86%