Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

Veronica, Natalia; Loh, Yi Ying; Loh, Lydia Xiu Ying; Heng, Paul Wan Sia; Liew, Celine Valeria

doi:10.1007/s40005-023-00647-6

J. Pharm. Investig.

2023

DOI: 10.1007/s40005-023-00647-6

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Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

Natalia Veronica,

Yi Ying Loh,

Lydia Xiu Ying Loh

et al.

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2024

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Cited by 2 publications

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Dexamethasone nanocrystals-embedded hydroxypropyl methylcellulose hydrogel increases cochlear delivery and attenuates hearing loss following intratympanic injection

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Carbohydrate Polymers

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Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties

Veronica,

Heng,

Liew

2024

AAPS PharmSciTech

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Magnesium stearate (MgSt) is a common tablet lubricant. As variations in MgSt properties are known to influence tablet attributes, the impact of MgSt fatty acid composition, particularly the significance of the stearate and palmitate contents, and its effects on tablet properties warrant further investigation. This study investigated the effect of MgSt with different stearate and palmitate contents but comparable physical properties (e.g. particle size, crystallinity, specific surface area and morphology) on lubrication performance and resulting tablet quality attributes, including mechanical strength, disintegratability and drug release. The influence of MgSt concentration and blending duration on the resulting tablet properties was also examined. Tablets produced using the lower stearate content MgSt had slightly higher tensile strength. The effect of MgSt stearate content was more apparent in the disintegration time and drug release, whereby MgSt of lower stearate content resulted in tablets with longer disintegration time and slower drug release. The lower stearate content also resulted in a lower lubrication performance, leading to a lesser reduction in tablet ejection force. As expected, a longer blending time of the tablet formulation blend with MgSt yielded tablets with reduced tensile strength, shorter disintegration time and slower drug release. Tablets with higher MgSt concentration showed a greater reduction in tensile strength, longer disintegration time and faster drug release. The study findings reinforced observations by other researchers and provided a better understanding of the fatty acid composition effects of MgSt on lubrication performance and the resulting tablet properties. Graphical Abstract

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Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

Cited by 2 publications

References 47 publications

Dexamethasone nanocrystals-embedded hydroxypropyl methylcellulose hydrogel increases cochlear delivery and attenuates hearing loss following intratympanic injection

Dexamethasone nanocrystals-embedded hydroxypropyl methylcellulose hydrogel increases cochlear delivery and attenuates hearing loss following intratympanic injection

Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties

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