Impact of magnesium sulfate therapy in improvement of renal functions in high fat diet-induced diabetic rats and their offspring

Touliat, Mohammad Vahid; Rezazadeh, Hossein; Beyki, Mehran; Maghareh-Dehkordi, Sajad; Sharifi, Mohammadreza; Talebi, Ardeshir; Soltani, Nepton

doi:10.1038/s41598-023-29540-w

Cited by 3 publications

(1 citation statement)

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“…Intravenous magnesium sulfate administration during surgery led to significantly lower BG and insulin requirements 60,61 . A potential mechanism for improvement of insulin sensitivity is upregulation of GUT-4 gene expression, leading to increase in glucose utilization in peripheral tissues [62][63][64] . There is also strong evidence linking diuretics to insulin resistance with an association independent of confounders 65 .…”

Section: Discussionmentioning

confidence: 99%

Medications that Regulate Gastrointestinal Transit Influence Inpatient Blood Glucose

Momenzadeh,

Cranney,

Choi

et al. 2024

Preprint

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ObjectiveA multitude of factors affect a hospitalized individual’s blood glucose (BG), making BG difficult to predict and manage. Beyond medications well established to alter BG, such as beta-blockers, there are likely many medications with undiscovered effects on BG variability. Identification of these medications and the strength and timing of these relationships has potential to improve glycemic management and patient safety.Materials and MethodsEHR data from 103,871 inpatient encounters over 8 years within a large, urban health system was used to extract over 500 medications, laboratory measurements, and clinical predictors of BG. Feature selection was performed using an optimized Lasso model with repeated 5-fold cross-validation on the 80% training set, followed by a linear mixed regression model to evaluate statistical significance. Significant medication predictors were then evaluated for novelty against a comprehensive adverse drug event database.ResultsWe found 29 statistically significant features associated with BG; 24 were medications including 10 medications not previously documented to alter BG. The remaining five factors were Black/African American race, history of type 2 diabetes mellitus, prior BG (mean and last) and creatinine.DiscussionThe unexpected medications, including several agents involved in gastrointestinal motility, found to affect BG were supported by available studies. This study may bring to light medications to use with caution in individuals with hyper- or hypoglycemia. Further investigation of these potential candidates is needed to enhance clinical utility of these findings.ConclusionThis study uniquely identifies medications involved in gastrointestinal transit to be predictors of BG that may not well established and recognized in clinical practice.

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