Impact of major age-related eye disorders on health-related quality of life assessed by EQ-5D: a systematic review and meta-analysis

Kai, Jia-Yan; Xu, Yue; Li, Dan-Lin; Zhou, Miao; Wang, Pei; Pan, Chen-Wei

doi:10.1007/s00417-023-06034-z

Cited by 1 publication

(2 citation statements)

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“…AMD is a typical age-related disease, and as long-term complication of diabetes, DR can also be numbered among this group; untreated, both lead to retinal neurodegeneration and blindness [ 5 ]. As an organ with particularly high levels of oxygen consumption and light processing to generate vision, the retina is constantly producing ROS and is thus particularly prone to OS [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…In accelerated aging, ROS production can no longer be controlled, and age-related diseases, such as cardiovascular diseases, metabolic disorders, cancer, and neurodegeneration, are the consequence [ 1 , 2 , 3 ]. Particularly in industrialized countries, health care has improved, and consequently life expectancy has increased [ 4 , 5 ]. Thus, the prevalence of age-related diseases is increasingly significant and has become a severe burden in terms of the quality of life of patients, health care, and socio-economic systems (as analyzed, e.g., by Bae et al for Korea [ 6 ]).…”

Section: Introductionmentioning

confidence: 99%

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Mammalian Animal and Human Retinal Organ Culture as Pre-Clinical Model to Evaluate Oxidative Stress and Antioxidant Intraocular Therapeutics

Kropp,

Mohit,

Leroy-Ciocanea

et al. 2023

Antioxidants

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Oxidative stress (OS) is involved in the pathogenesis of retinal neurodegenerative diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR) and an important target of therapeutic treatments. New therapeutics are tested in vivo despite limits in terms of transferability and ethical concerns. Retina cultures using human tissue can deliver critical information and significantly reduce the number of animal experiments along with increased transferability. We cultured up to 32 retina samples derived from one eye, analyzed the model’s quality, induced OS, and tested the efficiency of antioxidative therapeutics. Bovine, porcine, rat, and human retinae were cultured in different experimental settings for 3–14 d. OS was induced by a high amount of glucose or hydrogen peroxide (H2O2) and treated with scutellarin, pigment epithelium-derived factor (PEDF), and/or granulocyte macrophage colony-stimulating factor (GM-CSF). The tissue morphology, cell viability, inflammation, and glutathione level were determined. The retina samples showed only moderate necrosis (23.83 ± 5.05 increased to 27.00 ± 1.66 AU PI-staining over 14 d) after 14 days in culture. OS was successfully induced (reduced ATP content of 288.3 ± 59.9 vs. 435.7 ± 166.8 nM ATP in the controls) and the antioxidants reduced OS-induced apoptosis (from 124.20 ± 51.09 to 60.80 ± 319.66 cells/image after the scutellarin treatment). Enhanced mammalian animal and human retina cultures enable reliable, highly transferable research on OS-triggered age-related diseases and pre-clinical testing during drug development.

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Section: Discussionmentioning

confidence: 99%