Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women

Anabire, Nsoh Godwin; Aryee, Paul Armah; Abdul-Karim, Abass; Quaye, Osbourne; Awandare, Gordon A.; Helegbe, Gideon Kofi

doi:10.1371/journal.pone.0215550

Cited by 19 publications

(39 citation statements)

References 34 publications

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“…Though P. falciparum and HBV majorly trigger the release of the pro-inflammatory cytokines [16], the infections appeared not to markedly influence the inflammatory responses in the traders. It has been suggested that adults with P. falciparum infection show controlled inflammatory responses due to increased history of exposure, and that higher parasite loads are required to elicit the inflammatory responses and cause disease symptoms [33].…”

Section: Discussionmentioning

confidence: 87%

“…Also, it is common to find adults with chronic hepatitis B virus (HBV) infection who experience no disease symptoms [13]. Though current evidence shows no links between P. falciparum or HBV and CVDs [14,15], both pathogenic diseases majorly trigger inflammatory immune responses [16], and could exacerbate inflammatory responses in adults involved in chronic sedentary lifestyle, which may predispose them to hypertension and CVD.…”

Section: Introductionmentioning

confidence: 99%

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Asymptomatic malaria and hepatitis B do not influence cytokine responses of persons involved in chronic sedentary activities

et al. 2020

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Background Chronic Sedentary lifestyles have been linked to increased odds of stress, elevated anxiety and diminished wellbeing, inducing cytokine production and predispose to hypertension and other cardiovascular diseases. In endemic areas, Plasmodium falciparum and hepatitis B virus (HBV) infections can trigger pro-inflammatory cytokine responses. However, the impact of these infections on cytokine response profiles in individuals engaged in chronic sedentary activities is unknown. This study was aimed at addressing these concerns using a predominantly sedentary population of traders in the Tamale metropolis of Ghana. Method Four hundred respondents were categorized, based on their number of working years (< or ≥ 5 years) and number of working hours per day (< or ≥ 10 h), into sedentary (≥5 years + ≥ 10 h) and non-sedentary (≥ 5 years + < 10 h, < 5 years + ≥ 10 h and < 5 years + < 10 h) groups. The participants were tested for P. falciparum and HBV infections using polymerase chain reaction. Blood pressure and cytokines responses were measured. Associations and comparison analysis between variables were determined, and test statistics with p < 0.05 were considered statistically significant. Results Infection status included: un-infected (93.5%), P. falciparum mono-infected (1.0%), HBV mono-infected (3.0%) or P. falciparum /HBV co-infected (2.5%). Majority of the participants, 57.0% (n = 228) were involved in chronic sedentary life style. That notwithstanding, sedentary lifestyle was independent of the infection groups (χ2 = 7.08, p = 0.629). Hypertension was diagnosed in 53.8% of respondents and was independent of infection status (X2 = 6.33, p = 0.097). Pro-inflammatory (TNF-α, IL-1β, IL-6, IL-8 and IL-12) and anti-inflammatory (IL-10, IL-7 and IL-13) cytokine responses were similar among individuals with different sedentary working time and between hypertensive and non-hypertensive individuals (p > 0.05 for all comparisons). Among individuals with different infection status, pro-inflammatory (TNF-α; p = 0.290, IL-1β; p = 0.442, IL-6; p = 0.686, IFN-γ; p = 0.801, IL-8; p = 0.546, IL-12; p = 0.154) and anti-inflammatory (IL-10; p = 0.201, IL-7; p = 0.190, IL-13; p = 0.763) cytokine responses were similar. Conclusion Our data suggest that asymptomatic infections of P. falciparum and HBV together with a high prevalence of hypertension did not have any significant impact on cytokine response profiles among predominantly sedentary traders in the Tamale metropolis of Ghana.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Asymptomatic malaria and hepatitis B do not influence cytokine responses of persons involved in chronic sedentary activities

et al. 2020

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“… 15 Overlapping HBV/malaria coinfection cases have been reported previously. 16 , 17 Both pathogens share an intrahepatic life cycle developmental stage, which may increase mortality and morbidity. 11 Nonetheless, whether HBV exerts an effect on the clinical presentation of malaria remains debatable.…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury and Jaundice in a Patient With Concurrent Severe Malaria and Acute Exacerbation of Hepatitis B

Jonny

Violetta

2021

Journal of Investigative Medicine High Impact Case Reports

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Patients chronically infected with hepatitis B virus (HBV) may travel to areas with high endemicity of malaria. The overlap between malaria and HBV infection can be clinically severe and present a diagnostic challenge as both diseases manifest similar symptoms. This case describes a fatal case of a 43-year-old man with chronic HBV infected with Plasmodium falciparum malaria that presents as acute kidney injury (AKI) and jaundice following a trip to malaria-endemic region. Despite administering antimalarial and 6 courses of renal replacement therapy, the patient’s clinical condition did not improve, leading to septic shock, multi-organ dysfunction, and eventually, death. AKI and jaundice are commonly seen in severe P. falciparum malaria, as well as acute exacerbation of chronic HBV. This case emphasizes the importance to consider malarial screening when evaluating sick returning travelers, even in those with underlying chronic HBV. Given the severity of coinfection, prompt identification of this overlap can avert the rapid deterioration of severe malaria by early administration of intravenous artesunate and renal replacement therapy.

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“…While studies abound on epidemiology of single infection by P. falciparum and T. gondii, very few reports are available on co-infection of the two parasites. Meanwhile, several reports have associated malaria and toxoplasmosis with infections like hepatitis virus, HIV and helminths (Simpore et al, 2006;Ouermi et al, 2009;Cuadros et al, 2011;Morenikeji et al, 2016a,b;Jegede et al, 2017;Helegbe et al, 2018;Anabire et al, 2019). Only three countries in Sub-Saharan Africa had epidemiological data on co-infection of malaria and toxoplasmosis (Table 3).…”

Section: Concomitant Occurrence Of Malaria and Toxoplasmosis: The Knomentioning

confidence: 99%

Cerebral Malaria and Toxoplasmosis: Could their Concomitant Presentation Worsen Psychotic Condition?

Ibrahim

Atilola

Mohammed

et al. 2020

Annals of Science and Technology

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Malaria and toxoplasmosis are two important parasitic diseases with significant public health concerns in the Sub-Saharan African countries. Some aspects of pathogenesis of the two parasitic diseases involve the central nervous system manifesting neuropsychiatric disorders. Studies have implicated the single infection by Plasmodium spp. and Toxoplasma gondii in development of psychosis. Although concomitant infection of the two parasites suggests an aggravated psychotic condition, there is currently no reported study. This article reviewed some studies which implicated malaria and toxoplasmosis in psychosis. It further explored the likely role of concurrent infection by the parasites on psychosis, the dynamics of their pathology and possible effects of certain psychosis-associated cytokines and other biomolecules on the central nervous system. We recommend evidence-based research efforts in this field for the effective management of these two parasitic diseases to abate the public health burden of psychosis.

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Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women

Cited by 19 publications

References 34 publications

Asymptomatic malaria and hepatitis B do not influence cytokine responses of persons involved in chronic sedentary activities

Asymptomatic malaria and hepatitis B do not influence cytokine responses of persons involved in chronic sedentary activities

Acute Kidney Injury and Jaundice in a Patient With Concurrent Severe Malaria and Acute Exacerbation of Hepatitis B

Cerebral Malaria and Toxoplasmosis: Could their Concomitant Presentation Worsen Psychotic Condition?

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