Impact of Malaria Parasitaemia on Haematologic Parameters in Pregnant Women at Booking in Ilorin, Nigeria

Adesina, KT; Balogun, OR; Babatunde, Abiola S.; Sanni, M. A.; Fadeyi, A.; Aderibigbe, S.A.

doi:10.3923/tmr.2009.84.90

Cited by 12 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the drop in haemoglobin concentrations in the malarious subjects (Table 1) approximately connoted mild anaemia. The decreased PCV levels were also expected from previous reports (Adesina et al, 2009;Ogbodo et al 2010;Kayode et al, 2011). Furthermore, the drop in PCV values in the two malarious groups confirmed symptoms of anaemia in these study groups.…”

Section: Discussionsupporting

confidence: 90%

“…In another study, Kayode et al (2011) indicated significant increase (p > 0.05) in WBC of malaria and malaria typhoid co-infected patients, which they posited could have been elicited by increased production of leukocytes at the onset of the infection to wade off malaria parasite and typhoid pathogens. Similarly, increase in WBC in pregnant and non-pregnant malaria patients has been reported by Adesina et al (2009) and Sumbele et al (2010). However, the works of Ali et al (2009) noted both increased and decreased WBC in the blood of typhoid patients examined in Dubai.…”

Section: Discussionsupporting

confidence: 69%

“…Although haematologic and biochemical indices of P. falciparum infected individuals of Nigerian origin have been widely reported (Udesen, 2003;Egwunyenga et al, 2004;Adesina et al, 2009;Kayode et al, 2011), specific records on blood chemistry of infected inhabitants of Owerri Municipality have been poorly documented and not widely reported in this regard. Nevertheless, there are reports on high prevalence of P. falciparum malaria amongst inhabitants of South Eastern Nigeria (Udesen, 2003;Ibekwe et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Haematologic and biochemical indices of Plasmodium falciparum infected inhabitants of Owerri, Imo State, Nigeria

Chidoka¹

2013

J. Med. Lab. Diagn.

View full text Add to dashboard Cite

In spite of threats malaria pose to public health, specific records on alterations in some haematologic and biochemical indices of inhabitants of Owerri Municipality infected with P. falciparum malaria have not received wide reports and documentation. Accordingly, the present study sought to investigate alterations in haematologic and biochemical indices of moderately P. falciparum infected male inhabitants of Owerri Municipality. Haematologic and biochemical indices were estimated by spectrophotometric methods. Haemoglobin concentrations of malarious subjects within age brackets of 11 to 20 and 21 to 31 years were below reference interval; [Hb] M;11-21 years = 10.53 ± 0.23 g/dl (p < 0.05); [Hb] M; 21-31 years = 11.51 ± 1.10 g/dl (p < 0.05). There was no significant difference (p > 0.05) in erythrocyte sedimentation rate (ESR) between the two malarious groups; ESR M; 11-20 years = 29.80 ± 0.74 mm/h; ESR M; 21-31 years = 26.51 ± 1.42 mm/h. Packed cell volume (PCV) of malarious subject gave the following values: PCV% M; 11-20 years = 26.82 ± 0.78; PCV% M; 21-31 years = 25.82 ± 0.78; p > 0.05. Serum white blood cell count (WBC) was raised in malarious subjects compared to control groups (p > 0.05) except with WBC × 10 3 M; 21-30 years = 13.77 ± 3.95; p > 0.05. Serum albumin was lower in malarious subjects; [Albumin] M; 11-20 years = 4.70 ± 0.05 mg/dl and [Albumin] M; 21-31 years = 4.31 ± 0.09 mg/dl; p > 0.05, whereas, serum creatinine concentrations of malarious subjects gave higher values: [Creatinine] M; 11-20 years = 0.88 ± 0.71 mg/dl and [Creatinine] M; 21-31 years = 1.14 ± 0.42 mg/dl; p > 0.05. Serum urea concentrations of malarious subjects were significantly (p < 0.05) higher than the corresponding non-malarious age group. Serum fasting blood sugar (FBS) was significantly (p < 0.05) lower in malarious groups compared to corresponding non-malarious subjects. Specifically, [FBS] M; 11-20 years = 63.34 ± 1.66 mg/dl and [FBS] M; 21-31 years = 69.45 ± 1.25 mg/dl; p < 0.05. Subjects with moderate malaria infection showed symptoms of anaemia, alterations in nitrogen and carbohydrate metabolism, exemplified by raised serum level of urea and low level of FBS.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Haematologic and biochemical indices of Plasmodium falciparum infected inhabitants of Owerri, Imo State, Nigeria

Chidoka¹

2013

J. Med. Lab. Diagn.

View full text Add to dashboard Cite

show abstract

“…The presence of a lower MCHC in febrile controls is more intriguing. A literature search reveals at least one prior paper where a rise in MCHC in pregnant women correlated with malaria [14]. Attempts to diagnose dengue by hematology analyzers have been few in comparison with malaria.…”

Section: Discussionmentioning

confidence: 99%

LH750 hematology analyzers to identify malaria and dengue and distinguish them from other febrile illnesses

Sharma

Bhargava

Sukhachev

et al. 2013

Int J Lab Hematology

View full text Add to dashboard Cite

Leukocyte abnormalities quantitated by automated analyzers successfully identified malaria and dengue and distinguished them from other fevers. These economic discriminant functions can be rapidly calculated by analyzer software programs to generate electronic flags to trigger-specific testing. They could potentially transform diagnostic approaches to tropical febrile illnesses in cost-constrained settings.

show abstract

“…Malaria infection has been described as a pathological condition associated with significant mortality and morbidity [1]. In the areas of Africa where malaria is endemic, an average prevalence value of 27.8% representing 1:4 of the population of pregnant women are infected with malaria parasitaemia [2]. It is estimated that 125 million pregnant women are living in malaria predominant areas, and 32 million pregnancies are at risk of complications arising from malaria infection [3].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Fibrinolytic Response amongst Malarious Pregnant and Non Malarious Subjects in Rivers State, Nigeria

Ken-Ezihuo

Mbeera

Ibeh

et al. 2020

IBRR

View full text Add to dashboard Cite

Aim: The study was designed to comparatively assess the degree of fibrinolytic response amongst malaria-positive pregnant women, and non-malaria positive subjects in Rivers State, Nigeria. Methods: The study area covered University of Port Harcourt Teaching Hospital, Port Harcourt [UPTH] and Rivers State University Teaching Hospital, [RSUTH] both in Port Harcourt metropolis Rivers State. It was a cross-sectional study carried out on a total of two hundred and forty female attendees at the obstetrics and gynecology clinics of the two hospitals. The subjects were grouped into three comprising of eighty subjects in each group; malarious pregnant women, non- malarious pregnant women and apparently healthy non-pregnant women. Venous blood sample measuring 5 milliliter volume was drawn from each subject, The sample was dispensed into two separate EDTA anticoagulant bottles, 3 milliliter and 2 milliliter meant for measuring the levels of markers of fibrinolysis which were Plasminogen, Plasminogen activator inhibitor-1, Plasminogen activator inhibitor-2, Tissue Plasminogen activator, alpha-2-antiplasmin, D-dimers and fibrinogen, and preparation of blood films for malaria microscopy respectively. Results: Fibrinogen result; 760.44±16.18 ng/ml of malaria-positive pregnant women was elevated compared to the malaria-negative women; 697.70±18.84 ng/ml and the non-pregnant control values of 704.73±15.25 ng/ml. These values were significantly different [P<.011] between the study groups. Results of tissue plasminogen activator [tPA]; 46.39±2.69 ng/ml, D-dimer; 77.64±6.94 ng/ml, plasminogen activator inhibitor-1 [PAI-1]; 89.73±2.14 ng/ml, plasminogen activator inhibitor-2 [PAI-2]; 568.00±12.51 ng/ml, plasminogen; 23.82±0.75 ng/ml and 2-antiplasmin; 1314.06±34.64 ng/ml of the malaria-positive pregnant women were significantly different [P=0.0001] from non-positive pregnant women; tPA; 28.87±1.38 ng/ml, D-dimer; 53.90±1.18 ng/ml., PAI-1; 80.00± 1.81 ng/ml, PAI-2; 456.31±5.94 ng/ml, Plasminogen; 16.63±0.67 ng/ml and 2-antiplasmin; 1130.61±29.74 ng/ml . Both results were significantly different [P=0.0001] from the non-pregnant control group; tPA; 31.34±1.64 ng/ml, D-dimer; 30.24±1.04 ng/ml, PAI-1; 65,47±2,33 ng/ml, PAI-2; 427.86±6.95 ng/ml, plasminogen; 16.49±0.04 ng/ml and 2-antiplasmin; 1016.98±24.51 ng/ml. Conclusion: The study witnessed significantly high concentrations of fibrinolytic markers in malaria-positive pregnant women. This could be due to compromised endothelial cell function resulting to overproduction of biomarkers of fibrinolysis. The implication is thrombus formation and excessive bleeding in pregnancy which could lead to miscarriages, fetal death or maternal mortality.

show abstract

Impact of Malaria Parasitaemia on Haematologic Parameters in Pregnant Women at Booking in Ilorin, Nigeria

Cited by 12 publications

References 15 publications

Haematologic and biochemical indices of Plasmodium falciparum infected inhabitants of Owerri, Imo State, Nigeria

Haematologic and biochemical indices of Plasmodium falciparum infected inhabitants of Owerri, Imo State, Nigeria

LH750 hematology analyzers to identify malaria and dengue and distinguish them from other febrile illnesses

Comparative Study of Fibrinolytic Response amongst Malarious Pregnant and Non Malarious Subjects in Rivers State, Nigeria

Contact Info

Product

Resources

About