Impact of male age on the outcome of assisted reproductive technology cycles using donor oocytes

Effect of male age on the outcome of in vitro fertilization: oocyte donation as a model

“…Some studies from Europe and USA found that the increase of male age may lead to elevation of miscarriage rate after ART [4,[11][12][13]. We also found that male aging may be related to the increase of pregnancy loss in the first trimester of pregnancy.…”

“…The contribution of advancing female age to pregnancy outcomes is well documented, yet knowledge on effects of male age is much less [1,2]. Studies have shown that semen parameters, such as volume [3], total sperm count [4], sperm DNA integrity [3,5] and so on, would diminish with the increase of male age, which may undermine male fecundity. However, semen parameters are only indirect indicators of male fecundity and cannot reflect the effect of aging on male fecundity directly.…”

The effect of age on the expression of apoptosis biomarkers in human spermatozoa

“…This model allows controlling for the effects of variation of oocyte quality by female age. In our program we found that semen volume, sperm motility, and fertilization rate decreased significantly with advanced male age, but there was no correlation between age and mean embryo morphology scores, implantation, pregnancy rate (PR) or miscarriage rate (26).…”

Aging of the Male Germline: Influence of Advanced Male Age on Reproductive Outcome

“…Moreover, some evidences suggest that APA may affect embryo development, due to a decrease in quality and genomic integrity of spermatozoa from older individuals. Controversially, a meta-analysis research by Dain and peers, and a research by Duran and peers, using donor oocytes, for IVF and IVF/ ICSI procedures have stated that paternal aging is not associated with an increased risk of pregnancy loss after an established pregnancy [88,90]. However, although a study conducted by Frattarelli and peers has been involved in the previous meta-analysis, it is important to emphasize that these authors demonstrated that men above 50 years old displayed an increase in pregnancy loss and lower blastocyst formation and live birth rates [85].…”