The imbalance of the regional economy is not only a problem that cannot be ignored in the process of regional development but also an inevitable problem. This problem will be affected not only by its own development but also by government intervention. Since the reform and opening-up, China’s economy has been growing rapidly. At the same time, the problem of regional economic imbalance is also extremely prominent. Jiangxi Province is close to the developed areas in the East, and its economy is also developing rapidly. At the same time, Jiangxi Province also shows an increasingly serious problem of regional economic imbalance. Therefore, the author proposes to study the problem of regional economic disequilibrium in Jiangxi Province to provide reliable suggestions for the development of the economy of Jiangxi Province. To analyze the regional economic differences among several prefecture-level cities in Jiangxi Province, we first calculate the standard deviation of GDP per capita and the population-weighted coefficient of variation in Jiangxi Province and then perform the geographical decomposition and industrial decomposition to obtain the Taylor index and Gini coefficient. Finally, qualitative and quantitative analyses were conducted to calculate the magnitude of each index factor on the economic growth of the north and south regions of Jiangxi Province, and corresponding countermeasure suggestions were proposed based on the research results. The results show that the research results of this paper are beneficial to the countermeasures for the coordinated development of the regional economy in Jiangxi Province.