Impact of material properties and process parameters on tablet quality in a continuous direct compression line

Batch vs. continuous direct compression – a comparison of material processability and final tablet quality

“…2 kg of the prepared blend was used for characterization tests as described by Janssen et al (2023) . The data generated during these trials were used for data interpretation.…”

“…0.2 mm) and a main compression force (MCF) of 10 kN were applied. The press was operated in a manual mode (identical to the continuous trials; Janssen et al, 2023 ) to avoid tablet rejection based on weight. Hence, the fill depth (FD) and compression roller heights (i.e.…”

“…One overall model, describing the batch trials for the 1% and 40% blends, was created and optimized in order to increase the goodness of fit (R 2 ) and predictive ability (Q 2 ). Additionally, the overall CDC-model developed in a previous paper ( Janssen et al, 2023 ) was used to allow an in-depth comparison between both batch and continuous processing. Furthermore, an additional model containing data from both the batch and continuous trials was developed.…”

“…The study was performed on a stand-alone MODUL S tablet press (GEA, Halle, Belgium) where no PDV valve was present. In order to have a more profound comparison between the batch and continuous process, the rotary tablet press was configured in a similar fashion as the integrated MODUL S tablet press used in the study by Janssen et al (2023) which collected the continuous process data.…”

“…1%) and high-dosed (i.e. 40%) formulations in a batch-wise manner and compared the observations to CDC data generated during a previous study ( Janssen et al, 2023 ). The acquired data sets were produced using a similar setup (i.e.…”