Impact of maternal asthma on perinatal outcomes: a two-stage sampling cohort study

Firoozi, Faranak; Lemière, Catherine; Beauchesne, Marie-France; Perreault, Sylvie; Forget, Amélie; Blais, Lucie

doi:10.1007/s10654-012-9654-1

Cited by 29 publications

(31 citation statements)

References 42 publications

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“…However, the effect of asthma during pregnancy on BW is poorly characterized. Although some studies found no association between maternal asthma and BW (25), others reported lower BW in infants born to asthmatic women (26). Severe exacerbations of asthma or moderate to severe asthma during pregnancy have been shown to increase the risk of LBW (29), while maternal forced expiratory volume in one second is directly positively associated with BW (23).…”

Section: Discussionmentioning

confidence: 97%

Association between Maternal Characteristics and Neonatal Birth Weight in a Korean Population Living in the Seoul Metropolitan Area, Korea: A Birth Cohort Study (COCOA)

et al. 2013

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Previous studies suggest that maternal characteristics may be associated with neonatal outcomes. However, the influence of maternal characteristics on birth weight (BW) has not been adequately determined in Korean populations. We investigated associations between maternal characteristics and BW in a sample of 813 Korean women living in the Seoul metropolitan area, Korea recruited using data from the prospective hospital-based COhort for Childhood Origin of Asthma and allergic diseases (COCOA) between 2007 and 2011. The mean maternal age at delivery was 32.3 ± 3.5 yr and prepregnancy maternal body mass index (BMI) was 20.7 ± 2.5 kg/m2. The mean BW of infant was 3,196 ± 406 g. The overall prevalence of a maternal history of allergic disease was 32.9% and the overall prevalence of allergic symptoms was 65.1%. In multivariate regression models, prepregnancy maternal BMI and gestational age at delivery were positively and a maternal history of allergic disease and nulliparity were negatively associated with BW (all P < 0.05). Presence of allergic symptoms in the mother was not associated with BW. In conclusion, prepregnancy maternal BMI, gestational age at delivery, a maternal history of allergic disease, and nulliparity may be associated with BW, respectively.

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Section: Discussionmentioning

confidence: 97%

Association between Maternal Characteristics and Neonatal Birth Weight in a Korean Population Living in the Seoul Metropolitan Area, Korea: A Birth Cohort Study (COCOA)

et al. 2013

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“…It is also possible that preterm birth and asthma share common genetic determinants or environmental exposures. For instance, studies have indicated that maternal asthma is associated with both preterm birth and childhood asthma [9,52]. …”

Section: Discussionmentioning

confidence: 99%

Birth weight, gestational age, fetal growth and childhood asthma hospitalization

Liu

Olsen

Agerbo

et al. 2014

All Asth Clin Immun

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BackgroundChildhood asthma may have a fetal origin through fetal growth and development of the immunocompetence or respiratory organs.ObjectiveWe examined to which extent short gestational age, low birth weight and fetal growth restriction were associated with an increased risk of asthma hospitalization in childhood.MethodsWe undertook a cohort study based on several national registers in Denmark, Sweden and Finland. We included all live singleton born children in Denmark during 1979-2005 (N = 1,538,093), in Sweden during 1973-2004 (N = 3,067,670), and a 90% random sample of singleton children born in Finland during 1987-2004 (N = 1,050,744). The children were followed from three years of age to first hospitalization for asthma, emigration, death, their 18th birthday, or the end of study (the end of 2008 in Denmark, and the end of 2007 in Sweden or Finland), whichever came first. We computed the pseudo-values for each observation and used them in a generalized estimating equation to estimate relative risks (RR) for asthma hospitalization.ResultsA total of 131,783 children were hospitalized for asthma during follow-up. The risk for asthma hospitalization consistently increased with lower birth weight and shorter gestational age. A 1000-g decrease in birth weight corresponded to a RR of 1.17 (95% confidence interval (CI) 1.15-1.18). A one-week decrease in gestational age corresponded to a RR of 1.05 (95% CI 1.04-1.06). Small for gestational age was associated with an increased risk of asthma hospitalization in term but not in preterm born children.ConclusionsFetal growth and gestational age may play a direct or indirect causal role in the development of childhood asthma.

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“…There are conflicting results regarding the impact of asthma on pregnancy . Studies indicate association of disease with low APGAR score and or intrauterine growth restricted newborns in addition to prematurity, especially related to the severity of the disease [19]. However, in meta-analysis performed by Murphy et al, no increased risk was verified for the adverse events [20].…”

Section: Discussionmentioning

confidence: 97%

Exacerbation of Asthma during Pregnancy: Fetomaternal Outcomes

Ghimire

Ghimire²,

Ghimire³

2016

J Nobel Med Coll

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BackgroundAsthma is a common occurrence during pregnancy. Exacerbation during pregnancy represents a important and challenging medical problem and may result in poor fetomaternal outcomes. Until now, there are no studies comparing the fetomaternal outcomes in pregnant women with case (asthma) exacerbation and with control group (non-asthma) women of similar age and period of gestation. Therefore, we analysed selected fetomaternal outcomes retrospectively in these group of women. Material & MethodsThis is a retrospective observational comparative study. During the study period, total number of deliveries was 5,568. Women who were admitted with the diagnosis of exacerbation of asthma during pregnancy between 1st Jan 2015 to 31 st Dec were included in the study. These cases were compared with random selection of controls who were admitted in the same duration of time for the delivery without asthma after matching maternal age and period of gestation. Ethical clearance was obtained before the study. Fetomaternal outcomes were compared between women with exacerbation of asthma and non-asthma. Results One hundred and eight pregnant women from each asthmatic and non-asthmatic group were analysed for selected fetomaternal outcomes. The mean age of asthmatic and nonasthmatic group was 23.2± 4.3 and 24.9±3.2 years respectively. LSCS, UTI and preeclampsia were more common in asthmatic women. Birth weight and APGAR score was lower in babies with asthmatic women. Inpatient care and mortality rate were more common in babies of asthmatic women. Conclusion Exacerbation of asthma during pregnancy may result in poor fetomaternal outcome. Therefore, a more careful monitoring of women with exacerbation of asthma during pregnancy and delivery is required.

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Impact of maternal asthma on perinatal outcomes: a two-stage sampling cohort study

Cited by 29 publications

References 42 publications

Association between Maternal Characteristics and Neonatal Birth Weight in a Korean Population Living in the Seoul Metropolitan Area, Korea: A Birth Cohort Study (COCOA)

Association between Maternal Characteristics and Neonatal Birth Weight in a Korean Population Living in the Seoul Metropolitan Area, Korea: A Birth Cohort Study (COCOA)

Birth weight, gestational age, fetal growth and childhood asthma hospitalization

Exacerbation of Asthma during Pregnancy: Fetomaternal Outcomes

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