Impact of Maternal Depression on Infant Nutritional Status and Illness

Rahman, Atıf; Iqbal, Zafar; Bunn, James; Lovel, Hermione; Harrington, Richard

doi:10.1001/archpsyc.61.9.946

Cited by 617 publications

(556 citation statements)

References 24 publications

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“…Indeed, PPD/A in humans have been linked to adverse child outcomes, including later cognitive deficits and emotional disturbances (Feldman et al., 2009; Murray & Cooper, 1996; O'CONNOR, Heron, & Glover, 2002), and PPD specifically has been associated with offspring growth retardation and risk for being underweight (Rahman, Iqbal, Bunn, Lovel, & Harrington, 2004). Similarly, we observed that BCAA mothers had smaller pups at weaning.…”

Section: Discussionmentioning

confidence: 99%

Perinatal western‐type diet and associated gestational weight gain alter postpartum maternal mood

et al. 2017

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IntroductionThe role of perinatal diet in postpartum maternal mood disorders, including depression and anxiety, remains unclear. We investigated whether perinatal consumption of a Western‐type diet (high in fat and branched‐chain amino acids [BCAA]) and associated gestational weight gain (GWG) cause serotonin dysregulation in the central nervous system (CNS), resulting in postpartum depression and anxiety (PPD/A).MethodsMouse dams were fed one of four diets (high‐fat/high BCAA, low‐fat/high BCAA, high‐fat, and low‐fat) prior to mating and throughout gestation and lactation. Postpartum behavioral assessments were conducted, and plasma and brain tissues assayed. To evaluate potential clinical utility, we conducted preliminary human studies using data from an extant sample of 17 primiparous women with high GWG, comparing across self‐reported postpartum mood symptoms using the Edinburgh Postnatal Depression Scale (EPDS) for percent GWG and plasma amino acid levels.ResultsMouse dams fed the high‐fat/high BCAA diet gained more weight per kcal consumed, and BCAA‐supplemented dams lost weight more slowly postpartum. Dams on BCAA‐supplemented diets exhibited increased PPD/A‐like behavior, decreased dopaminergic function, and decreased plasma tyrosine and histidine levels when assessed on postnatal day (P)8. Preliminary human data showed that GWG accounted for 29% of the variance in EPDS scores. Histidine was also lower in women with higher EPDS scores.ConclusionsThese findings highlight the role of perinatal diet and excess GWG in the development of postpartum mood disorders.

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Section: Discussionmentioning

confidence: 99%

Perinatal western‐type diet and associated gestational weight gain alter postpartum maternal mood

et al. 2017

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“…The majority (61.7%) of studies were facility-based, 34.0% were community-based and n=2 studies were conducted in both settings. The range of study designs is wide, from small-n (n=18) qualitative research (Niemi et al, 2010) to case control design (n=320) Rahman et al, 2004a) to large-scale (n=19,030) experimental intervention research (Tripathy et al, 2010). …”

Section: Figure 1 About Herementioning

confidence: 99%

“…Health Maternal health/nutrition/hunger (Bell et al, 2008;Nakku et al, 2006;Pollock et al, 2009) (Ho-Yen et al, 2007Nakku et al, 2006;Patel et al, 2002;Pollock et al, 2009) - Infant health (Patel et al, 2002;Rahman et al, 2004b) Rahman et al, 2004a;Ross et al, 2010) (Adewuya et al, 2008;Patel et al, 2002;Rahman et al, 2004b) ---…”

Section: Table 2: Examples Of Poverty Indicator Definitions From Studmentioning

confidence: 99%

Poverty and postnatal depression: a systematic mapping of the evidence from low and lower middle income countries

et al. 2012

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This study systematically maps, assesses and aggregates research relating to postnatal depression (PND) and poverty in low and lower middle income countries (LLMICs). Our search of 12 databases yielded 2,202 articles, of which 47 items from 17 countries were included in our mapping. We highlight mechanisms for the relationships between poverty and PND in LLMICs. The research base on the relationships between poverty and PND in LLMIC is limited, but has recently expanded. It is dominated by studies that consider whether poverty is a risk factor for PND. Income, socio-economic status and education are all inconsistent risk factors for PND. Clues to better ways of framing and capturing economic stress in PND research is found in the qualitative studies included in our mapping. Evidence focuses overwhelmingly on individual-level analyses. To understand the scale and implications of PND in LLMICs, research has to take account of neighbourhoods, communities, and localities.

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“…3 Although only 5 to 8% of pregnant women meet criteria for major depressive disorder, 4 about 20% of women may experience depressive symptoms during pregnancy and postpartum and this situation often goes undiagnosed and untreated. [4][5][6] This is an important risk factor for postnatal depression and evidence suggests that gestational depression may be associated with several negative outcomes, such as low birth weight, preterm birth, and abnormal child development. [5][6][7][8] Conventional treatment options for depression include psychotropic agents (especially antidepressants), psychotherapy, and electroconvulsive therapy (ECT), which is indicated in the most severe or treatmentrefractory cases.…”

Section: Introductionmentioning

confidence: 99%

Transcranial magnetic stimulation for treatment of major depression during pregnancy: a review

Felipe

Ferrão

2016

Trends Psychiatry Psychother.

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Introduction: Pregnancy is characterized by a high prevalence of mental disorders. Depression is the most common of these disorders and it is a risk factor for negative maternal and child development outcomes. Psychotherapy and pharmacotherapy are conventional and well-established therapeutic options, but some clients fail to respond and the safety of using some pharmacological agents during pregnancy is unclear. Some neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), have been studied in depressed pregnant women. Objective: To evaluate the safety and efficacy of rTMS for major depression in pregnant women. Methods: The LILACS and PubMed databases were reviewed using the search terms depression, pregnancy and magnetic stimulation. Texts including primary data, published in Portuguese, Spanish, or English, between 1995 and2014, that evaluated depressed pregnant women and used rTMS as the intervention were selected. Papers lacking sufficient data were excluded. Twenty-two texts were initially identified; after applying the inclusion criteria, 12 were selected and analyzed. Results: The studies reviewed reported satisfactory responses to rTMS in acute depressive episodes, as measured using depressive symptom scales. Remission of symptoms was achieved in many cases. The procedure was well tolerated and there were no reports of damage/complications to unborn children. Conclusion:The data available at this time support the efficacy and tolerability of rTMS for depression in pregnant women. Controlled studies should corroborate this conclusion. This review only included studies in three languages and the resulting sample size was not large enough to conduct a meta-analysis.

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Impact of Maternal Depression on Infant Nutritional Status and Illness

Cited by 617 publications

References 24 publications

Perinatal western‐type diet and associated gestational weight gain alter postpartum maternal mood

Perinatal western‐type diet and associated gestational weight gain alter postpartum maternal mood

Poverty and postnatal depression: a systematic mapping of the evidence from low and lower middle income countries

Transcranial magnetic stimulation for treatment of major depression during pregnancy: a review

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