Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting

Ibrahim, Romesa; Ali, Sajjad; Kazi, Abdul Momin; Rizvi, Arjumand; Guterman, L. Beryl; Bednarczyk, Robert A.; Kim, Ellie; Park, Sohee; Paulos, Simon; Jeyachandran, Amilia; Patel, Divya; Gorantla, Yamini; Wong, Emily Y.; Rajam, Gowrisankar; Schiffer, Jarad; Omer, Saad B.

doi:10.1016/j.vaccine.2018.09.045

Cited by 14 publications

(7 citation statements)

References 7 publications

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“…The use of wP vaccines but not aP vaccines was associated with a substantial reduction in the subsequent infant antibody response to PT in infants born to mothers with high levels of maternally-derived anti-PT antibodies ( 179 ). In another study, there was no correlation between low anti- B. pertussis antibody levels at delivery in infants born to unvaccinated women and their anti- B. pertussis antibody levels after wP vaccination ( 180 ).…”

Section: Impact Of Maternal Immunization On Infants' Immune Responsesmentioning

confidence: 97%

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Global Perspectives on Immunization During Pregnancy and Priorities for Future Research and Development: An International Consensus Statement

et al. 2020

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Section: Impact Of Maternal Immunization On Infants' Immune Responsesmentioning

confidence: 97%

“…pertussis antibody levels at delivery in infants born to unvaccinated women and their anti-B. pertussis antibody levels after wP vaccination (180).…”

Section: Pertussis Vaccinesmentioning

confidence: 99%

Global Perspectives on Immunization During Pregnancy and Priorities for Future Research and Development: An International Consensus Statement

et al. 2020

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“…Antibody functionality, however, was better in the wP groups. In another study, no correlation was found between low anti- B. pertussis antibody levels at delivery in infants born to unvaccinated women and their anti- B. pertussis antibody levels after wP vaccination [ 121 ].…”

Section: Boosters and The Relevance Of Immunization During Pregnancymentioning

confidence: 99%

Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity

et al. 2022

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After the pertussis vaccine had been introduced in the 1940s and was shown to be very successful in reducing the morbidity and mortality associated with the disease, the possibility of improving both vaccine composition and vaccination schedules has become the subject of continuous interest. As a result, we are witnessing a considerable heterogeneity in pertussis vaccination policies, which remains beyond universal consensus. Many pertussis-related deaths still occur in low- and middle-income countries; however, these deaths are attributable to gaps in vaccination coverage and limited access to healthcare in these countries, rather than to the poor efficacy of the first generation of pertussis vaccine consisting in inactivated and detoxified whole cell pathogen (wP). In many, particularly high-income countries, a switch was made in the 1990s to the use of acellular pertussis (aP) vaccine, to reduce the rate of post-vaccination adverse events and thereby achieve a higher percentage of children vaccinated. However the epidemiological data collected over the past few decades, even in those high-income countries, show an increase in pertussis prevalence and morbidity rates, triggering a wide-ranging debate on the causes of pertussis resurgence and the effectiveness of current pertussis prevention strategies, as well as on the efficacy of available pertussis vaccines and immunization schedules. The current article presents a systematic review of scientific reports on the evaluation of the use of whole-cell and acellular pertussis vaccines, in the context of long-term immunity and vaccines efficacy.

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“…A few studies have been published recently about the influence of maternal antibodies in the neonatal humoral response, as the study made by Ibrahim et al [29]. Women that did not receive Tdap during pregnancy but had detectable pertussis antibody levels showed that maternal antibody titres at delivery did not blunt infant vaccine response among children that receive at least 2 wP doses, and the authors observed that infant antibody titres increased with increasing maternal antibody levels against all pertussis antigens.…”

Section: Discussionmentioning

confidence: 99%

Gestational pertussis vaccination and the infant’s cellular immune response against whole-cell pertussis vaccine in the first year of life

Correia

Vaz-de-Lima

Uehara

et al. 2019

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25Pertussis resurgence worldwide calls for new prevention strategies, as the recently 26 incorporated vaccine booster dose during pregnancy, whose aim is to protect newborns 27 from infection. In Brazil, maternal Tdap vaccination is recommended since 2014, and we 28 reported that this strategy promotes high transplacental transfer of anti-PT IgG and it is 29 effective in protecting infants early in life. Young children are the most susceptible group 30 and with higher mortality rates, however, it is not well known whether the elicited anti-31 pertussis maternal antibodies could influence in the children's immune responses further 32 in life, especially after their own vaccination against pertussis. Considering this scenario, 33 we conducted a study with children born to mothers who either received or not the booster 34 dose during pregnancy, after their primary pertussis vaccination, in order to investigate 35 the first impact of maternal immunisation on the response to infant immunisation 36 regarding the cellular immune response, while comparing with data from the literature. 37As transfer of maternal antibodies could result in attenuation of the immune response to 38 vaccination in infants, this study performed to determine whether higher levels of 39 maternal antibodies could influence in the immune response of infants to the whole-40 pertussis vaccination series. Results showed no difference in cytokine production 41 between groups, a first suggestion that maternal vaccination may not interfere with 42 recognition and cellular response generation to vaccination. This data, together with 43 humoral immunity and epidemiological studies, is important for the implementation of 44 maternal immunisation strategies nationwide and will contribute to assure public policies 45 regarding vaccination schemes. 46 47 Importance: Pertussis, or whopping cough, is a respiratory infectious disease caused by 48 a bacterial agent, resulting in violent coughs and possibly death in vulnerable groups, 49 3 such as young children and neonates. It is known that pregnant mothers transfer 50 antibodies to their developing foetuses for protection in early life, however anti-pertussis 51 antibodies are not highly detected in young children. Thus, a pertussis maternal 52 vaccination was implemented to increase maternal anti-pertussis antibodies levels in 53 pregnant women and therefore the transference to the foetus. However, maternal 54 antibodies can also interfere in the child immune response in the first months of life. The 55 significance of our research is in analysing the cellular immune response of children born 56 from pertussis-vaccinated mothers, which will give a first glimpse on how maternal 57 antibodies could modulate the child's response to pertussis in early life. 58 59 Introduction 60 Pertussis is a contagious respiratory disease caused by the Bordetella pertussis bacteria 61 [1]. Despite high vaccination coverage, it remains an important public health problem, re-62 emerging in several countries every several yea...

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Impact of maternally derived pertussis antibody titers on infant whole-cell pertussis vaccine response in a low income setting

Cited by 14 publications

References 7 publications

Global Perspectives on Immunization During Pregnancy and Priorities for Future Research and Development: An International Consensus Statement

Global Perspectives on Immunization During Pregnancy and Priorities for Future Research and Development: An International Consensus Statement

Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity

Gestational pertussis vaccination and the infant’s cellular immune response against whole-cell pertussis vaccine in the first year of life

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