Impact of meibomian gland width on successful contact lens use

Pucker, Andrew D.; Jones‐Jordan, Lisa A.; Kunnen, Carolina; Marx, Sebastian; Powell, Daniel R.; Kwan, Justin; Srinivasan, Sruthi; Sickenberger, Wolfgang; Jones, Lyndon

doi:10.1016/j.clae.2019.06.004

Cited by 19 publications

(36 citation statements)

References 43 publications

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“…Although no difference was found in meibomian gland atrophy between dropouts from lens wear (aged 18-45 years), sex and age-matched successful contact lens wearers had less upper eyelid tortuosity, but greater tortuosity in the lower eyelid [359]. Upper and lower meibomian gland plugging and worse meibum quality were observed in the dropout group [359] and worse secretion quality associated with discomfort has also been confirmed in existing symptomatic contact lens wearers [320] and amongst habitual contact lens wearers [362].…”

Section: Patient-related Risk Factorsmentioning

confidence: 76%

BCLA CLEAR - Contact lens complications

Stapleton

Bakkar

Carnt

et al. 2021

Contact Lens and Anterior Eye

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Contact lens-related complications are common, affecting around one third of wearers, although most are mild and easily managed. Contact lenses have well-defined anatomical and physiological effects on the ocular surface and can result in other consequences due to the presence of a biologically active material. A contact lens interacts with the tear film, ocular surface, skin, endogenous and environmental microorganisms, components of care solutions and other antigens which may result in disease specific to contact lens wear, such as metabolic or hypersensitivity disorders. Contact lens wear may also modify the epidemiology or pathophysiology of recognised conditions, such as papillary conjunctivitis or microbial keratitis. Wearers may also present with intercurrent disease, meaning concomitant or pre-existing conditions unrelated to contact lens wear, such as allergic eye disease or blepharitis, which may complicate the diagnosis and management of contact lens-related disease.Complications can be grouped into corneal infection (microbial keratitis), corneal inflammation (sterile keratitis), metabolic conditions (epithelial: microcysts, vacuoles, bullae, tight lens syndrome, epithelial oedema; stromal: superficial and deep neovascularisation, stromal oedema [striae/folds], endothelial: blebs, polymegethism/ pleomorphism), mechanical (corneal abrasion, corneal erosion, lens binding, warpage/refractive error changes; superior epithelial arcuate lesion, mucin balls, conjunctival epithelial flaps, ptosis, discomfort), toxic and allergic disorders (papillary conjunctivitis, solution-induced corneal staining, incomplete neutralisation of peroxide, Limbal Stem Cell Deficiency), tear resurfacing disorders/dry eye (contact lens-induced dry eye, Meibomian gland dysfunction, lid wiper epitheliopathy, lid parallel conjunctival folds, inferior closure stain, 3 and 9 o'clock stain, dellen, dimple veil) or contact lens discomfort. This report summarises the best available evidence for the classification, epidemiology, pathophysiology, management and prevention of contact lensrelated complications in addition to presenting strategies for optimising contact lens wear.

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Section: Patient-related Risk Factorsmentioning

confidence: 76%

BCLA CLEAR - Contact lens complications

Stapleton

Bakkar

Carnt

et al. 2021

Contact Lens and Anterior Eye

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“…Although obstructed material in MGD can lead to dilatation of the central duct, this widening may be offset by acinar atrophy that results from the same process [23,26,29]. More recently, Pucker et al (2019) observed that narrower MGs were associated with worsening expressibility in successful and unsuccessful contact lens wearers; however there was no significant difference in MG tortuosity and width between the two groups [30]. Together with the present results, this suggests that width does not influence MG function, nor correspond to tear film parameters or symptoms and therefore can be ignored as an informative metric by clinicians.…”

Section: Discussionmentioning

confidence: 99%

Effect of meibomian gland morphology on functionality with applied treatment

Bilkhu

Vidal-Rohr

Trave-Huarte

et al. 2022

Contact Lens and Anterior Eye

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“…So far, many studies have been conducted to investigate the effects of contact lens (CL) wear on MGs structure and function. Arita et al 27 found that CL wear is associated with a decrease in the number of functional MGs while Machalinska et al and Pucker et al [28][29][30][31] made a conclusion that CL wear does not appear to in uence MGs. Alghamdi et al 32 found alterations to MGs morphology and function but it occurred during the rst 2 years of CL wear.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Meibomian Glands Using the Tear Interferometer Wearing Orthokeratology Lenses

Lee¹,

Hwang²,

Ha³

et al. 2021

Preprint

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Background : To investigate the impact of orthokeratology wear on meibomian glands in Korean pediatric population using the tear interferometer. Methods : Fifty-three orthokeratology wearers and 79 non-lens wearers were evaluated using the LipiView® II ocular surface interferometer which shows incomplete blink rate, average lipid layer thickness, and meiboscores.Results : No significant differences in the incomplete blink rate and meiboscores for upper eyelids, but the lipid layer thickness and meiboscores for lower eyelids were significantly higher in the Ortho-K group than in the control group (p = 0.024 and 0.007, respectively). Correlation analysis showed no significant correlation between the duration of orthokeratology wear and the parameters measured by LipiView® (p > 0.05 for all). Among subgroups based on average duration of lens wear, the longer duration (≥24 months) subgroup showed higher meiboscores of lower eyelids (p = 0.011), but no other significant differences. Conclusions : Ortho-K wearers showed no significant differences in the incomplete blink rate and meiboscores of upper eyelids, but they were associated with increased LLT and higher meiboscores of lower eyelids. Thorough examination and close monitoring of orthokeratology wearers is necessary. Prospective and observational studies are needed to further elucidate the relationship between Orthokeratology and meibomian glands.

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Impact of meibomian gland width on successful contact lens use

Cited by 19 publications

References 43 publications

BCLA CLEAR - Contact lens complications

BCLA CLEAR - Contact lens complications

Effect of meibomian gland morphology on functionality with applied treatment

Evaluation of the Meibomian Glands Using the Tear Interferometer Wearing Orthokeratology Lenses

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