Impact of Metabolic Syndrome and Its Components on Clinical Severity and Long-Term Prognosis in Patients With Premature Myocardial Infarction

Gao, Jing; Wang, Yuan; Yang, Ya-Nan; Wu, Xiao‐Yuan; Cui, Yan; Zou, Zhong-He; Cui, Zhuang; Liu, Yin

doi:10.3389/fendo.2022.920470

Cited by 9 publications

(7 citation statements)

References 56 publications

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“…MetS patients not only are at higher risk of developing myocardial infarction (MI) ( 122 ), but they also tend to have larger infarct size and more in-hospital complications ( 123 ). Of all the different components of MetS, hyperglicemia and BMI ≥28.0 kg/m 2 are associated with major adverse cardiovascular events (MACE) in patients with MI aged <45 year ( 124 ). Moreover, MetS in acute coronary syndrome (ACS) is significantly more present in women (55.9%-66.3%) than in men (40.2%-47.3%) ( 125 , 126 ).…”

Section: Discussionmentioning

confidence: 99%

Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review

Saccaro,

Aimo,

Panichella

et al. 2024

Front. Psychiatry

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IntroductionPeople with psychosis spectrum disorders (PSD) face an elevated risk of metabolic syndrome (MetS), which may reduce their life expectancy by nearly 20%. Pinpointing the shared and specific characteristics and clinical implications of MetS in PSD is crucial for designing interventions to reduce this risk, but an up-to-date review on MetS across the psychosis spectrum is lacking.MethodsThis narrative review fills this gap by examining the clinical literature on characteristics and implications of MetS in both distinct PSD and transdiagnostically, i.e., across traditional categorical diagnoses, with a focus on psychiatric and cardio-metabolic management.ResultsWe discuss common and specific characteristics of MetS in PSD, as well as factors contributing to MetS development in PSD patients, including unhealthy lifestyle factors, genetic predisposition, pro-inflammatory state, drugs consumption, antipsychotic medication, and psychotic symptoms. We highlight the importance of early identification and management of cardio-metabolic risk in PSD patients, as well as the existing gaps in the literature, for instance in the screening for MetS in younger PSD patients. We compare hypotheses-generating clinical associations and characteristics of MetS in different PSD, concluding by reviewing the existing recommendations and challenges in screening, monitoring, and managing MetS in PSD.ConclusionEarly identification and management of MetS are crucial to mitigate the long-term cardio-metabolic toll in PSD patients. Interventions should focus on healthy lifestyle and appropriate pharmacological and behavioral interventions. Further translational and clinical research is needed to develop targeted interventions and personalized treatment approaches for this vulnerable population, aiming at improving physical health and overall well-being.

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Section: Discussionmentioning

confidence: 99%

Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review

Saccaro,

Aimo,

Panichella

et al. 2024

Front. Psychiatry

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“…To the literature, Obese patients with heart failure have lower concentrations of NT-proBNP due to increased expression of scavenger receptors and increased degradation of the peptides by adipose tissue [14]. It has previously been shown that people with HFpEF and normal NT-proBNP levels had a higher risk of death or rehospitalization from HF compared to people without HF [15]. Clinical studies have shown that patients with HFpEF and low levels of NT-proBNP responded better to mineralocorticoid receptor antagonists and angiotensin receptor blockers compared to patients with higher levels of NT-proBNP [16 -twenty].…”

Section: Discussionmentioning

confidence: 99%

Diastolic function and its relationship with the ATP-III criteria for metabolic syndrome in a Latin American cohort

Estévez Gómez,

Acevedo Peña,

Castillo Goyeneche

et al. 2023

Preprint

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INTRODUCTION: In South America, heart failure poses a substantial concern due to its widespread occurrence and insufficient data accuracy. Metabolic syndrome, a risk factor for heart disease and diabetes, is the focal point of the study, which seeks to examine its correlation with left ventricular diastolic function (LVDF) and indications of heart failure in adults within a South American hospital. MATERIALS AND METHODS: A cross-sectional study with 2380 adults aged 65-79 in a South American hospital reveals connections between metabolic syndrome (MetS) and heart health. Using ATP-III criteria, MetS was identified, and cardiac function was assessed by echocardiography. Significant associations between MetS and various cardiac indicators were found. RESULTS: Metabolic Syndrome (MetS) affected 33.1% of the sample, showing health differences and cardiac alterations, including ejection fraction changes. Associations with diastolic dysfunction criteria and complex relationships between natriuretic peptides and ventricular filling pressure were observed. CONCLUSIONS:Metabolic syndrome links to significant changes in diastolic function and left ventricular structure, but not with alterations in the left atrium. Nevertheless, individuals with Metabolic Syndrome are more prone to receiving a diagnosis of chronic heart failure. Further extensive studies in diverse populations are advised.

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“…1. Consequently, the meta-analysis included 10 observational studies [19][20][21][22][23][24][25][26][27][28].…”

Section: Study Retrievalmentioning

confidence: 99%

“…These studies were performed in Italy, Japan, Korea, Serbia, and China, and published between 2005 and 2022. As for study design, five studies were prospective cohort studies [21,23,25,27,28], four were retrospective cohort [20,22,24,26], and another one was post-hoc analysis of a clinical trial [19]. All the studies included patients with MI (total sample size: 33 197), with mean age of the patients varying from 41 to 71 years.…”

Section: Study Characteristicsmentioning

confidence: 99%

Influence of Metabolic Syndrome on the Long-Term Prognosis of Patients with Myocardial Infarction: A Meta-Analysis

Chen,

Shi,

Qian

2023

Horm Metab Res

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The influence of metabolic syndrome (MetS) on long-term prognosis of patients with myocardial infarction (MI), the most severe type of coronary artery disease, remains not fully determined. This systematic review and meta-analysis were conducted to investigate the association between MetS and long-term clinical outcomes of patients with MI. A systematic search of Medline, Web of Science, and Embase databases from inception to June 25, 2023, was conducted to obtain eligible studies. Only studies with follow-up duration for at least one year were considered. A random-effects model was utilized to pool the results, accounting for heterogeneity. Ten observational studies were included, which included 33 197 patients with MI. Among them, 17 244 (51.9%) were with MetS at baseline. During a follow-up duration of 12 to 48 months (mean: 22.5 months), patients with MetS were associated with higher incidence of major adverse cardiovascular events [risk ratio (RR): 1.35. 95% confidence interval (CI): 1.19 to 1.54, p<0.001; I2=64%] and all-cause deaths (RR: 1.34, 95% CI: 1.18 to 1.52, p<0.001; I2=23%), as compared to those without MetS at baseline. Subgroup analyses showed that the results were not significantly affected by study characteristics such as study country, design, type of MI, mean age of the patients, treatment with percutaneous coronary intervention, follow-up durations, or study quality scores (p for subgroup difference all>0.05). In patients with MI, MetS may be a risk factor of poor long-term prognosis.

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Impact of Metabolic Syndrome and Its Components on Clinical Severity and Long-Term Prognosis in Patients With Premature Myocardial Infarction

Cited by 9 publications

References 56 publications

Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review

Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review

Diastolic function and its relationship with the ATP-III criteria for metabolic syndrome in a Latin American cohort

Influence of Metabolic Syndrome on the Long-Term Prognosis of Patients with Myocardial Infarction: A Meta-Analysis

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