Impact of metabolic syndrome on clinical severity and long-term prognosis in patients with myocardial infarction with ST-segment elevation

Lovic, M.; Djordjević, Dragan; Tasić, I.; Nedeljkovic, I.

doi:10.1016/j.hjc.2018.02.002

Cited by 21 publications

(45 citation statements)

References 24 publications

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“…Viši kardiovaskularni rizik u MS posledica je aterosklerotskih promena 12 . Brojne studije su nesumnjivo pokazale da povećanje broja faktora rizika dovodi do ubrzanja procesa ateroskleroze, što se može objasniti činjenicom da upala uzrokovana MS ima važnu ulogu u ovom procesu 9 . Proinflamatorno stanje je direktno povezano sa uzrocima rezistencije na insulin, kao i aterogeneze (1,28).…”

Section: Discussionunclassified

“…12 Higher CV risk in MS is a consequence of atherosclerotic changes. 12 Numerous studies have proven, beyond a shadow of a doubt, that the increase in the number of risk factors leads to the acceleration of the atherosclerotic process, probably due to inflammation caused by MS. 9 Proinflammatory condition is in the direct connection with the causes of insulin resistance, as well as atherogenesis. 1,28 Inflammatory biomarkers concentration changes are thought to be a prevailing factor in the development of MS, mainly in older people.…”

Section: Discussionmentioning

confidence: 99%

“…Patients diagnosed with MS had to have at least three out of five diagnostic criteria: hypertriglyceridemia (tgl>1.7 mmol/l) or specific treatment for this lipid abnormality, low HDL cholesterol levels (<1.03 mmol/l in men and <1.29 mmol/l in women) or specific treatment for this lipid abnormality, systolic blood pressure >130 mmHg and/or diastolic blood pressure >85 mmHg or antihypertensive therapy, fasting glucose level > 5.6 mmol/l or antidiabetic therapy, and waist circumference > 102 cm for men and > 88 cm for women. 9 Data were processed using statistical package SPSS, version 23…”

Section: Methodsmentioning

confidence: 99%

“…Za postavljanje dijagnoze metaboličkog sindroma korišćeni su kriterijumi Američkog udruženja za srce (American Heart Association -AHA) i Nacionalnog instututa za srce, pluća i krv (National Heart, Lung and Blood Institute -NHL-BI). Metabolički sindrom su imali pacijenti koji su ispunjavali najmanje tri od sledećih pet kriterijuma: hipertrigliceridemija (Tgl>1,7 mmol/l) ili specifičan tretman za ovu abnormalnost lipida, nizak HDL holesterol (<1,03 mmol/l kod muškaraca i <1,29 mmol/l kod žena) ili specifičan tretman za ovu abnormalnost lipida; sistolni krvni pritisak >130 mmHg i/ili dijastolni krvni pritisak >85 mmol/L ili antihipertenzivna terapija; glikemija natašte >5,6 mmol/L ili antidijabetička terapija i obim struka >102 cm kod muškaraca i >88 cm kod žena 9 . logical data on the incidence of MS defer and are not quite precise and comparable for different geographic areas and populations.…”

Section: Metodunclassified

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Frequency and importance of metabolic syndrome and its components in outpatients

Miljkovic¹,

Todorović²

2019

Opšta medicina

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Uvod. Metabolički sindrom (MS) predstavlja grupu kardiovaskularnih faktora rizika koji uključuje hiperglikemiju, povišen krvni pritisak, povišene nivoe triglicerida, centralnu gojaznost i sniženi HDL holesterol. Rezultati populacionih studija pokazuju da je MS koristan u prognozi kardiovaskularnog morbiditeta i mortaliteta. Cilj rada. Ispitati učestalost i značaj metaboličkog sindroma i njegovih pojedinačnih komponenata u ambulantnih pacijenata. Metod. Studija je obuhvatila 178 (71,26±8,93) ambulantnih pacijenata odabranih metodom slučajnog uzorka, 67 (71,24±9,5) muškaraca i 111 (71,28±11,29) žena (p>0,05). Stanje uhranjenosti je ocenjeno na osnovu antropometrijskih parametara (telesna visina, telesna težina, obim struka). Kod svih ispitanika određivani su glikemija, HDL holesterol, trigliceridi i izmerene su vrednosti krvnog pritiska. Za postavljanje dijagnoze MS korišćeni su kriterijumi Američkog udruženja za srce (American Heart Association-AHA) i Nacionalnog instituta za srce, pluća i krv (National Heart, Lung and Blood Institute-NHLBI). Rezultati. Metabolički sindrom je dijagnostikovan kod 42,7% pacijenata, 31,6% muškaraca i 68,4% žena. Učestalost MS je bila veća kod žena (47,7%) u odnosu na muškarce (35,8%) (p>0,05); tri komponente MS imalo je 51,3%, četiri 42,1% i pet 6,6% ispitanika. Od pojedinačnih komponenata MS, najčešće je zastupljen povećan obim struka (92,1%). Sa koronarnom bolešću bilo je ukupno 10,5% pacijenata sa MS, a u grupi pacijenata bez MS 1,96% (p<0,01). U posmatranom periodu umrlo je 10,5% pacijenata sa MS i 0,98% bez MS (p<0,01). Zaključak. Učestalost metaboličkog sindroma u populaciji ambulantnih pacijenata je 42,7%, muškaraca 35,8% i žena 46,8%. Povećan obim struka je najčešća pojedinačna komponenta metaboličkog sindroma. Pacijenti sa metaboličkim sindromom imaju značajno veću učestalost koronarne

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Section: Discussionunclassified

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Metodunclassified

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Frequency and importance of metabolic syndrome and its components in outpatients

Miljkovic¹,

Todorović²

2019

Opšta medicina

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“…Metabolic syndrome in patients with myocardial infarction is independent risk factor for major adverse cardiovascular events ( Lovic et al, 2018 ). Mitochondrial dysfunction is involved in the progression of metabolic syndrome and is associated with the changes in eNOS, inducible NOS (iNOS), neuronal NOS (nNOS), and mtNOS signaling ( Litvinova et al, 2015 ).…”

Section: Inside Mitochondriamentioning

confidence: 99%

Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation

et al. 2018

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Irreversible myocardial damage happens in the presence of prolonged and severe ischemia. Several phenomena protect the heart against myocardial infarction and other adverse outcomes of ischemia and reperfusion (IR), namely: hibernation related to stunned myocardium, ischemic preconditioning (IPC), ischemic post-conditioning, and their pharmacological surrogates. Ischemic preconditioning consists in the induction of a brief IR to reduce damage of the tissue caused by prolonged and severe ischemia. Nitric oxide (NO) signaling plays an essential role in IPC. Nitric oxide-sensitive guanylate cyclase/cyclic guanosine-3′,5′-monophosphate (cGMP)-dependent protein kinase type I-signaling pathway protects against the IR injury during myocardial infarction. Mitochondrial ATP-sensitive and Ca2+-activated K+ channels are involved in NO-mediated signaling in IPC. Independently of the cGMP-mediated induction of NO production, S-nitrosation represents a regulatory molecular mechanism similar to phosphorylation and is essential for IPC. Unlike conditioning phenomena, the mechanistic basis of myocardial stunning and hibernation remains poorly understood. In this review article, we hypothesize that the disruption of electrical syncytium of the myocardium may underly myocardial stunning and hibernation. Considering that the connexins are the building blocks of gap junctions which represent primary structural basis of electrical syncytium, we discuss data on the involvement of connexins into myocardial conditioning, stunning, and hibernation. We also show how NO-mediated signaling is involved in myocardial stunning and hibernation. Connexins represent an essential element of adaptation phenomena of the heart at the level of both the cardio- myocytes and the mitochondria. Nitric oxide targets mitochondrial connexins which may affect electrical syncytium continuum in the heart. Mitochondrial connexins may play an essential role in NO-dependent mechanisms of myocardial adaptation to ischemia.

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Validation of DAPT score for prolonged dual antiplatelet therapy in patients with acute myocardial infarction

Esquivel

Batiz-Armenta

Cazares-Diazleal

et al. 2019

Hellenic Journal of Cardiology

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Impact of metabolic syndrome on clinical severity and long-term prognosis in patients with myocardial infarction with ST-segment elevation

Abstract: The presence of MetS in patients with STEMI is an independent risk factor for MACE, and this syndrome is strongly associated with new revascularization.

Cited by 21 publications

References 24 publications

Frequency and importance of metabolic syndrome and its components in outpatients

Frequency and importance of metabolic syndrome and its components in outpatients

Connexins and Nitric Oxide Inside and Outside Mitochondria: Significance for Cardiac Protection and Adaptation

Validation of DAPT score for prolonged dual antiplatelet therapy in patients with acute myocardial infarction

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