Impact of metabolic syndrome on functional outcomes and complications of surgical treatment of prostate cancer

Abstract

Background Metabolic syndrome (MetS) has a negative impact on functional recovery and complications after many surgical procedures. Aim To assess the role of Mets on functional outcomes and complications after radical prostatectomy (RP) for prostate cancer. Patients and Methods Complete data were collected from 5758 patients, undergoing RP at a single referral centers in a 10‐year period and the presence of MetS before surgery was ascertained in 17.7% of them using a modified version of the IDF‐AHA/NHLBI criteria. Outcomes included 1‐year continence and potency rates, early (≤90 days) and late (>90 days) complications. Results Postoperative continence (no pads) was significantly less likely in MetS patients (75.4% vs 82.6%, P < .01), despite no difference in preoperative continence. Erections with or without therapy were reached in 55.8% of non‐MetS and 41.8% of MetS patients (P < .01), in this case a significant difference in preoperative function was seen. No differences in early and late complications, except for wound infections (5.8% vs 3.9%, P < .01) were observed. Conclusions In the present study RP was safe from the complications standpoint in MetS patients, but the presence of the syndrome was a significant risk factor for post‐RP incontinence and impotence.

A Mendelian randomization study between metabolic syndrome and its components with prostate cancer

“…This study aims to explore the risk factors of PCa, thereby aiding in the identification of high-risk individuals and improving the efficiency of PCa screening and early detection opportunities. Furthermore, we hypothesize that treatments targeting metabolic syndrome, such as lifestyle interventions and pharmacotherapy, may contribute to improving the prognosis of PCa patients 45 . This would represent a highly intriguing research avenue.…”

Pre- and Postoperative Parameters on Magnetic Resonance Imaging Predict Continence Recovery after Laparoscopic Radical prostatectomy

“…Despite the etiology of PPI is multifactorial and complex, reduction of internal urethral pressure is the main factor. Several clinical parameters have been identi ed to be predictors of PPI, including age, body mass index (BMI), metabolic syndrome, prostate volume (PV), preoperative overactive bladder and neurovascular bundle (NVB) sparing [4][5][6]. Furthermore, urologists have proposed to predict continence recovery with preoperative anatomical parameters on magnetic resonance imaging (MRI) such as MUL and intravesical prostatic protrusion length (IPPL) [7,8].…”

Análisis comparativo y evolutivo de la prostatectomía radical en la última década. Impacto de la implantación de la cirugía robótica en un único centro español

“…Aunque algunos estudios previos han visto que el síndrome metabólico está asociado con una menor recuperación de la CU tras la PR [194], el nuestro podría ser el primer estudio que emplea el antecedente de IAM y/o el antecedente de ACV o AIT en un modelo de riesgo capaz de predecir la CU tras PR. Esto podría deberse a una relación entre las comorbilidades vasculares y la CU.…”