Impact of Metformin on Periodontal and Peri-Implant Soft and Hard Tissue

Aljofi, Faisal E.; Alesawy, Aminah; Alzaben, Bader; Alshaikh, Marwa; Alotaibi, Norah; Aldulaijan, Hajer A.; Alshehri, Sami; Aljoghaiman, Eman Ahmed; Al‐Dulaijan, Yousif A.; AlSharief, Mishali

doi:10.3390/ijerph20021095

Cited by 3 publications

(3 citation statements)

References 48 publications

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“…In addition, patients with diabetes are three times more likely to develop periodontitis (Aljofi et al, 2023;Preshaw & Bissett, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with type 2 diabetes may be at increased risk for postoperative complications due to infection or slow wound healing. In addition, patients with diabetes are three times more likely to develop periodontitis (Aljofi et al, 2023 ; Preshaw & Bissett, 2013 ). Antidiabetic drugs such as metformin have been shown to have a beneficial effect on bone tissue, acting on osteoblasts and reducing the risk of fractures in patients with diabetes (Bak et al, 2010 ; Cortizo et al, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

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An epidemiological qualitative/quantitative SWOT‐AHP analysis in order to highlight the positive or critical aspects of dental implants: A pilot study

Aliberti,

Funk,

De Stefano

et al. 2024

Clinical & Exp Dental Res

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ObjectivesIn recent years, dental implants are increasing in popularity due to their high success rate, demonstrated functionality, and aesthetic treatment results. Scientific research is very active in proposing improvements in the quality and survival of implants, taking into consideration various aspects. The objective of this study was to provide a holistic epidemiologic view of the state of dental implants, using a systematic approach based on a multimethod SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis and AHP (analytical hierarchical process) qualitative–quantitative analysis to identify the characteristics that can determine their success or failure.Materials and MethodsThe study used the hybrid method of SWOT‐AHP.ResultsAnalysis of the results showed that among strengths, the skill of the dentist was considered the most important factor, followed by the success of dental implants in the old people; among weaknesses, bruxism and chronic diseases were highlighted; for opportunities, biomechanical behavior, in terms of good mechanical strength and good tribological resistance to chemical and physical agents in the oral cavity, were considered the most important factors; finally, among threats, medical liability and biomechanical problems had equal weight.ConclusionsThis study applied a multimethod SWOT‐AHP approach to bring out favorable or critical evidence on the topic of dental implants. In accordance with the result of the strategic vector identified in the Twisting zone Adjustment type section, showed that implant surgery is a widespread technique but always needs improvement to increase the likelihood of success and reduce the complications that can lead to implant failure.

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“…In addition, patients with diabetes are three times more likely to develop periodontitis (Aljofi et al, 2023;Preshaw & Bissett, 2013).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An epidemiological qualitative/quantitative SWOT‐AHP analysis in order to highlight the positive or critical aspects of dental implants: A pilot study

Aliberti,

Funk,

De Stefano

et al. 2024

Clinical & Exp Dental Res

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“…[ 297 ] Metformin, commonly prescribed for type 2 diabetes patients, reduces the inflammatory response and oxidative stress and stimulates osteoblastic activity. [ 298 ] Alendronate, a bisphosphonate often used to treat osteoporosis, effectively suppresses bone resorption and possesses anti‐inflammatory properties. [ 299 ] In clinical trials, they have been administered as hydrogels, with a concentration of 1.2% for statins and 1% for alendronate and metformin, demonstrating improvements in clinical and radiographic parameters.…”

Section: Discussionmentioning

confidence: 99%

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

De Lauretis,

Øvrebø,

Romandini

et al. 2024

Advanced Science

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Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss. A step‐wise therapeutic approach is employed for periodontitis. After an initial behavioral and non‐surgical phase, intra‐bony or furcation defects may be amenable to regenerative procedures. This review discusses the regenerative technologies employed for periodontal regeneration, highlighting the current limitations and future research areas. The search, performed on the MEDLINE database, has identified the available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure or putty), and membranes. Biologicals and bone grafts have been critically analyzed in terms of composition, mechanism of action, and clinical applications. Although a certain degree of periodontal regeneration is predictable in intra‐bony and class II furcation defects, complete defect closure is hardly achieved. Moreover, treating class III furcation defects remains challenging. The key properties required for functional regeneration are discussed, and none of the commercially available biomaterials possess all the ideal characteristics. Therefore, research is needed to promote the advancement of more effective and targeted regenerative therapies for periodontitis. Lastly, improving the design and reporting of clinical studies is suggested by strictly adhering to the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement.

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Features of the Interrelationship of Periodontal Diseases and Somatic Diseases (Literature Review)

Vasko

Tkachenko

2023

Ukr. Dent. Alm.

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The interrelationship of periodontal diseases and somatic diseases has a two-way aggravating character. An analysis of modern scientific literature concerning the connection between periodontal diseases and systemic diseases of the human body has been realized. To collect information for this review, a search was conducted for the scientific literature presented in three databases (Pubmed, Scopus, Web of Science) for the past 2 years. Thirty-four studies, including reviews and original articles, were selected for qualitative analysis based on their relevance to the main content of this review. Numerous studies confirm the significant relationship between the severity of the course of oral inflammatory diseases, the state of its microbiome and the unfavorable prognosis of cardiovascular diseases, diseases of the respiratory system, metabolic syndrome, obesity, rheumatoid arthritis, etc. The presence of periodontitis in patients increases the risk of developing cardiovascular diseases, particularly coronary heart disease and stroke. A high prevalence of periodontal tissue diseases in people with chronic diseases of the digestive organs is noted, which is associated with a violation of all types of metabolism. Severe forms of periodontitis often coexist with diabetes of the first and second types and are considered the most frequent complications of diabetes. Recent studies have clearly substantiated the role of certain periodontal pathogenic microorganisms in the etiopathogenesis and complicated course of rheumatoid arthritis. Highly pathogenic microorganisms of the oral cavity, penetrating through the damaged epithelium of the vascular wall of the periodontal tissues into the systemic circulation, cause chronic bacteremia and affect distant organs and tissues. Since we cannot directly influence on the function of definite organs, it is advisable to prescribe not only basic periodontal treatment, but also the drugs that affect the vascular component of the inflammatory process, namely, strengthen the vascular wall and improve microcirculatory channel trophicity.

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Impact of Metformin on Periodontal and Peri-Implant Soft and Hard Tissue

Cited by 3 publications

References 48 publications

An epidemiological qualitative/quantitative SWOT‐AHP analysis in order to highlight the positive or critical aspects of dental implants: A pilot study

An epidemiological qualitative/quantitative SWOT‐AHP analysis in order to highlight the positive or critical aspects of dental implants: A pilot study

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

Features of the Interrelationship of Periodontal Diseases and Somatic Diseases (Literature Review)

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