Impact of microsatellite instability on survival of endometrial cancer patients

Kanopienė, Daiva; Smailytė, Giedrė; Vidugirienė, Jolanta; Bacher, Jeffery W.

doi:10.1016/j.medici.2014.09.002

Cited by 28 publications

(21 citation statements)

References 26 publications

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“…On the other hand, there was no significant difference in survival of these patients and they suggested that immune surveillance associated with MMR defects may counteract the effects of negative prognostic factors in these patients (Mc Meekin et al, 2016). Similarly in another study MSI-high status was detected in 15.6% endometrial cancers while no statistically significant differences between patients with MSI-high and MSI stable tumors was found after stage, histology and tumor grade adjustment on multivariate analysis (Kanopiene et al, 2014). Our results are concordant with these findings as we found association of MSI+ endometrial cancers with high TNM/ FIGO stage, however there was no association found with disease free survival.…”

Section: Cervical Invasionsupporting

confidence: 90%

Microsatellite Instability in Endometrial Carcinoma by Immunohistochemistry, Association with Clinical and Histopathologic Parameters

Hashmi

Mudassir

Hashmi³

et al. 2019

Asian Pac J Cancer Prev

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Section: Cervical Invasionsupporting

confidence: 90%

Microsatellite Instability in Endometrial Carcinoma by Immunohistochemistry, Association with Clinical and Histopathologic Parameters

Hashmi

Mudassir

Hashmi³

et al. 2019

Asian Pac J Cancer Prev

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“…Conversely, Mackay et al found that MSI tumors were common in patients with early‐stage disease, but were associated with worse prognosis in this cohort. Kanopiene et al evaluated 109 cases of endometrial cancer for MSI and found that there was no significant difference in survival rate between MSI and MSS tumors . An et al and Bilbao et al found that, in both early FIGO stage (I and II) and late FIGO stage III and IV endometrial cancer, MSI status was associated with higher grade, deeper myometrial invasion, and higher clinical stage with presence of lymph node metastases; however, we did not observe these correlations in our study probably because of the small sample size and since we did not have any patients with stage IV disease.…”

Section: Discussioncontrasting

confidence: 76%

Can reduced field‐of‐view diffusion sequence help assess microsatellite instability in FIGO stage 1 endometrial cancer?

Bhosale

Ramalingam

et al. 2016

Magnetic Resonance Imaging

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“…24,25 However, a later study, in 2014, showed no associations of MSI status with survival, tumor grade, tumor stage, or histologic examination findings in 109 patients. 26 In our study, a correlation between International Federation of Gynecology and Obstetrics grade and MSI status was observed. However, MSI status did not correlate with age at diagnosis or other pathologic characteristics, such as American Joint Committee on Cancer stage, tumor site, histologic type, cervix involvement, lymph-vascular invasion, tumor margin, or myometrial invasion, potentially due to our limited study cohort.…”

Section: Discussionsupporting

confidence: 63%

Differences in Microsatellite Instability Profiles between Endometrioid and Colorectal Cancers

Wang

Shi

Eisenberg

et al. 2017

The Journal of Molecular Diagnostics

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The ASCP designates this journal-based CME activity ("JMD 2017 CME Program in Molecular Diagnostics") for a maximum of 36 AMA PRA Category 1 Credit(s)ä. Physicians should claim only credit commensurate with the extent of their participation in the activity. CME Disclosures: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. Colorectal (CRCs) and endometrioid (EMCs) cancers in patients with Lynch syndrome exhibit microsatellite instability (MSI) detected by PCR or immunohistochemistry (IHC). While both assays are equally sensitive for CRCs, some suggest that PCR has a higher false-negative rate than IHC in EMCs. We assessed the MSI profiles of 91 EMC and 311 CRC specimens using five mononucleotide repeat markers: BAT25, BAT26, NR21, NR24, and MONO27. EMCs with high MSI (MSI-H) showed a mean left shift of 3 nucleotides (nt), which was significantly different from 6 nt in CRCs. A shift of 1 nt was observed in multiple markers in 76% of MSI-H EMCs, whereas only 12% of MSI-H CRCs displayed a 1-nt shift in one of five markers. IHC against four mismatch repair proteins was performed in 78 EMCs. Loss of staining in one or more proteins was detected in 18 of 19 tumors that were MSI-H by PCR. When EMC tumor cell burden was diluted to <30%, MSI-H was no longer observed in two of three EMCs with a mean nucleotide shift of 1 nt. These results indicate that EMC and CRC MSI profiles are different and that caution should be exercised when interpreting the results, as subtle, 1-nt changes may be missed. These findings provide a potential cause of previously reported discordant MSI and IHC results in EMCs. Lynch syndrome (LS) (Online Mendelian Inheritance in Man no. 120435), also referred as hereditary nonpolyposis colorectal cancer, is an autosomal dominant disorder with a relatively common disease prevalence of 1 in 440.1,2 About 2% to 3% of colorectal cancers (CRCs) and 1% to 2% of endometrioid cancers (EMCs; including endometrial cancer and endometrioid cancer of the ovary) are due to LS.3 LS is a heterogeneous disorder exhibiting reduced penetrance, differences in age of onset, and variability in expression.In LS patients, the lifetime risks are 50% to 70% for CRC and 40% to 60% for EMC in women, and the overall risk for other associated tumors is increased. 4 LS is caused by germline mutations in one of four mismatch repair (MMR) genes or by a deletion in the EPCAM locus affecting the adjacent MMR gene.5 These germline mutations result in defective MMR machinery that leads to microsatellite instability (MSI) throughout the genome and gives rise to tumors. Both Lynch-related and sporadic cancers can manifest MSI. MSI tumors are associated with a better prognosis yet a poor response to adjuvant 5-fluorouracil based chemotherapy.

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Impact of microsatellite instability on survival of endometrial cancer patients

Abstract: Our study showed no statistically significant relationship between MSI-high and survival of endometrial cancer patients.

Cited by 28 publications

References 26 publications

Microsatellite Instability in Endometrial Carcinoma by Immunohistochemistry, Association with Clinical and Histopathologic Parameters

Microsatellite Instability in Endometrial Carcinoma by Immunohistochemistry, Association with Clinical and Histopathologic Parameters

Can reduced field‐of‐view diffusion sequence help assess microsatellite instability in FIGO stage 1 endometrial cancer?

Differences in Microsatellite Instability Profiles between Endometrioid and Colorectal Cancers

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