2017
DOI: 10.3389/fendo.2017.00124
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Impact of Mid-Luteal Phase GnRH Agonist Administration on Reproductive Outcomes in GnRH Agonist-Triggered Cycles: A Randomized Controlled Trial

Abstract: ObjectiveTo explore whether the addition of a mid-luteal bolus of GnRH agonist (GnRHa) improves the implantation rate (IR) in in vitro fertilization (IVF) cycles.DesignA randomized controlled trial.SettingPrivate IVF center.Patients328 IVF/intracytoplasmic sperm injection patients were triggered with GnRHa and received 1,500 IU HCG on the day of oocyte pick-up (OPU) in addition to a standard luteal phase support (LPS).Intervention(s)In addition, the study group received a bolus of GnRHa 6 days after OPU, where… Show more

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Cited by 20 publications
(30 citation statements)
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“…On the other hand, in the subgroup of trials where the GnRH-A ovarian stimulation protocol was used, the CPR per transfer was significantly superior in the GnRHa group (41.38%; 180/435) than in the control group (31.11%; 149/479; P=0.040; RR=1.32, 95% CI=0.96-1.81; Fig. 4) (19,21,23,25,26).…”
Section: Resultsmentioning
confidence: 98%
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“…On the other hand, in the subgroup of trials where the GnRH-A ovarian stimulation protocol was used, the CPR per transfer was significantly superior in the GnRHa group (41.38%; 180/435) than in the control group (31.11%; 149/479; P=0.040; RR=1.32, 95% CI=0.96-1.81; Fig. 4) (19,21,23,25,26).…”
Section: Resultsmentioning
confidence: 98%
“…As above, a sensitivity analysis excluding the study by Ata and Urman (23) was performed (Fig. 5), and the pooled CPR per transfer was significantly higher in the GnRHa group (41.95%; 425/1,013) than that in the control group (32.92%; 342/1,039; P=0.001; RR=1.34, 95% CI=1.12-1.59) (19)(20)(21)(22)(24)(25)(26). This trend was more evident with the GnRH-A ovarian stimulation protocol (P<0.0001; RR=1.45, 95% CI=1.20-1.74) (19,21,25,26).…”
Section: Resultsmentioning
confidence: 99%
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“…The first signs and symptoms of the bureaucratic overload can already be seen. More and more ground-breaking clinical research is now conducted outside Europe and North America, quite often with the participation of European and American co-ordinators -typically in East Asia -not only due to a higher patient flow, but also due to faster, more focused and more efficient regulatory processes (Benmachiche et al, 2017;Vuong et al, 2016). Thus, outsourcing is not just an industrial issue, and several of these clinical research projects have already been published in high-impact international journals (Chen et al, 2016;Shi et al, 2018;Vuong et al, 2018).…”
Section: Outsourcingmentioning
confidence: 99%