Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease

Reginold, William; Duff‐Canning, Sarah; Meaney, Christopher; Armstrong, Melissa J.; Fox, Susan H.; Rothberg, Brandon; Zadikoff, Cindy; Kennedy, Norman J.; Gill, David; Eslinger, Paul J.; Marshall, F.J.; Mapstone, Mark; Chou, Kelvin L.; Persad, Carol; Litvan, Irene; Mast, Benjamin T.; Tang‐Wai, David F.; Lang, Anthony E.; Marras, Connie

doi:10.1159/000350032

Cited by 50 publications

(63 citation statements)

References 52 publications

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“…Previous studies have reported that the cognitive symptoms of PD produce severe negative effects on QoL [5,10], and these deficits frequently progress to dementia [25]. The literature regarding neuropsychological assessment of EOPD patients focuses on low rates of dementia in this population [2,24,32], with reports of cognitive deficits rare [24].…”

Section: Discussionmentioning

confidence: 99%

“…All cases were reviewed independently to assess if they met the MDS-established criteria for PDD [10] or PD-MCI [9], and the frequency of each diagnosis was determined (fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…Studies of LOPD patients have suggested that, even in patients without dementia, cognitive dysfunction has a significant impact on everyday functioning [7,8], QoL of patients [9,10] and caregivers [11], and also represents an increase in economic burden [12]. …”

Section: Introductionmentioning

confidence: 99%

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Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

Seubert-Ravelo

Yáñez-Téllez²,

Salgado–Ceballos³

et al. 2016

Dement Geriatr Cogn Disord

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Background/Aims: Few studies have described mild cognitive impairment (MCI) and cognitive characteristics in early-onset Parkinson's disease (EOPD). This study describes attention/working memory, language, memory, visuospatial abilities, executive function, and frequency of MCI and dementia in EOPD. Methods: Eighty-one EOPD patients were administered neuropsychological tests and the Beck Depression Inventory. Scores were compared with age/education-appropriate norms and were correlated to years of disease progression and severity of motor symptoms. The frequency of MCI and dementia was determined by the Movement Disorder Society criteria. Results: Thirty-one percent of patients met the MCI criteria, but none had dementia. Commonly affected domains were memory, visuospatial, and executive function. Cognitive dysfunction was not explained by depression or severity of motor symptoms. Conclusion: One third of EOPD patients presented with MCI, which was not associated with the same risk factors as reported in late-onset Parkinson's disease. MCI could have a different prognostic value in EOPD.

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Section: Discussionmentioning

confidence: 99%

“…All cases were reviewed independently to assess if they met the MDS-established criteria for PDD [10] or PD-MCI [9], and the frequency of each diagnosis was determined (fig. 1).…”

Section: Methodsmentioning

confidence: 99%

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Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

Seubert-Ravelo

Yáñez-Téllez²,

Salgado–Ceballos³

et al. 2016

Dement Geriatr Cogn Disord

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“…Cognitive decline affects the majority of patients with idiopathic Parkinson's disease (PD) and has a major impact on quality of life1 and morbidity,2 but the phenotype, pathophysiology, and genetics of the condition are incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease

et al. 2017

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ObjectivesCognitive decline is common in Parkinson's disease (PD), but the underlying mechanisms for this complication are incompletely understood. Genotypes affecting dopamine transmission may be of importance. This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2‐receptor availability (Catechol‐O‐methyltransferase [COMT] Val158Met genotype and DRD2 C957T genotype) affect the development of cognitive deficits in PD.Materials and methodsOne hundred and 34 patients with idiopathic PD, participating in a regional, population‐based study of incident parkinsonism, underwent genotyping. After extensive baseline investigations (including imaging and biomarker analyses), the patients were followed prospectively during 6‐10 years with neuropsychological evaluations, covering six cognitive domains. Cognitive decline (defined as the incidence of either Parkinson's disease mild cognitive impairment [PD‐MCI] or dementia [PDD], diagnosed according to published criteria and blinded to genotype) was studied as the primary outcome.ResultsBoth genotypes affected cognition, as shown by Cox proportional hazards models. While the COMT 158Val/Val genotype conferred an increased risk of mild cognitive impairment in patients with normal cognition at baseline (hazard ratio: 2.13, P = .023), the DRD2 957T/T genotype conferred an overall increased risk of PD dementia (hazard ratio: 3.22, P < .001). The poorer cognitive performance in DRD2 957T/T carriers with PD occurred mainly in episodic memory and attention.ConclusionsThe results favor the hypothesis that dopamine deficiency in PD not only relate to mild cognitive deficits in frontostriatal functions, but also to a decline in memory and attention. This could indicate that dopamine deficiency impairs a wide network of brain areas.

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“…Mild cognitive impairment in PD (PD-MCI) may be a precursor to PDD, and thus may also impact on QoL [2]. Furthermore, QoL may be affected by particular subtypes of MCI [1], where impairments in multiple domains may have greater cognitive burden and thus may cause greater difficulties in activities of daily living (ADL) and poorer QoL [3,4].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life and Mild Cognitive Impairment in Early Parkinson’s Disease: Does Subtype Matter?

Lawson

Yarnall

Duncan

et al. 2015

JPD

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Abstract. We evaluated the association between mild cognitive impairment (MCI) subtypes and quality of life (QoL) in 219 newly diagnosed Parkinson's disease (PD) patients without dementia. Participants completed neuropsychological tests of attention, executive function, visuospatial function, memory, and language, and reported QoL using the Parkinson's Disease Questionnaire. Impairments were most common in executive function, memory and attention. MCI subtypes were classified according to Movement Disorder Society Task Force criteria. More severe cognitive impairment was associated with poorer quality of life (p = 0.01), but subtype of impairment was not (p > 0.10), suggesting that the nature of cognitive impairment is less significant than its severity.

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Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease

Cited by 50 publications

References 52 publications

Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease

Quality of Life and Mild Cognitive Impairment in Early Parkinson’s Disease: Does Subtype Matter?

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