Impact of Minocycline Ointment for Periodontal Treatment of Oral Bacteria

Nakao, Ryoma; Takigawa, Satoko; Sugano, Naoyuki; Koshi, Ryosuke; Ito, Koichi; Watanabe, Haruo; Senpuku, Hidenobu

doi:10.7883/yoken.64.156

Cited by 18 publications

(2 citation statements)

References 8 publications

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“…"On the other hand, there are reports that the oral cavity is a reservoir of tetracycline-resistant genes mainly carried by transposon Tn916, and suggested the potential risk of widespread use of minocycline, a topical agent that has been shown to be effective in reducing periodontopathogens, which is discouraged due to concerns about emerging oral pathogens carrying genetic determinants responsible for antimicrobial action" [28].…”

Section: Treatment Of Wastementioning

confidence: 99%

Antimicrobial Sensitivity Associated with Porphyromonas gingivalis Present in Periodontitis Frameworks: An Integrative Review

Araújo,

Silva,

Prado

2024

ACRI

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Objectives: The Gram-negative anaerobic bacterium Porphyromonas gingivalis is identified as one of the most important causes of the chronic form of periodontitis. This work aimed to analyze the sensitivity of P. gingivalis to antibiotics and antimicrobial agents. Study Design: Integrative literature review. Methodology: Through a careful analysis of clinical trials published in the last 5 years. A bibliographic search was carried out in the PubMed, Scielo and Google Scholar databases. Three keywords were established and verified on the DeCs-Descritores em Ciências da Saúde website for the literary search “Antimicrobial resistance”, “Periodontal biotherapy” and “Porphyromonas gingivalis”. 66 articles were found. Of these, animal studies, studies that did not involve patients diagnosed with periodontitis according to the 2017 World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions, and studies on peri-implantitis were excluded. Studies that used only surgical therapy without association with at least one antibiotic or antimicrobial and duplicate studies were excluded. Results: This integrative review presents the results of 19 studies. Amoxicillin, Metronidazole and Azithromycin are the most commonly used antibiotics. Photodynamic therapy has demonstrated benefits in reducing inflammation and P. gingivalis counts. It has been demonstrated that P. gingivalis is not sensitive to Lactobacillus brevis and Lactobacillus plantarum-ProlcSan probiotic gel and tablets, as no reductions in its proportion and total count were observed. Similar results were also observed in the study that investigated the effect of administering piperacillin plus Tazobactam gel and doxycycline gel. Conclusion: Although most of the articles presented report the sensitivity of P. gingivalis to their protocols, microbiological reduction is not always accompanied by clinical benefit, since periodontal disease is multifactorial. Based on these findings, it is concluded that there are several antimicrobial agents capable of promoting the reduction of this key pathogen in periodontitis.

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Section: Treatment Of Wastementioning

confidence: 99%

Antimicrobial Sensitivity Associated with Porphyromonas gingivalis Present in Periodontitis Frameworks: An Integrative Review

Araújo,

Silva,

Prado

2024

ACRI

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“…It is a type of periodontal sustained-release local drug, with the main component of minocycline hydrochloride, which has the advantages of broad antibacterial spectrum and few drug-resistant bacteria [5]. It can alleviate various symptoms such as periodontitis and pulpitis caused by Porphyromonas gingivalis, Prevotella intermedia, Prevotella melaninogenicus, Ekeng corrosive bacteria, Fusobacterium nucleatum and Actinobacillus [6,7]. However, MHO may bring relatively serious side effects, including gastrointestinal symptoms, gastrointestinal diseases and dizziness [8].…”

Section: Introductionmentioning

confidence: 99%

Minocycline hydrochloride ointment combined with Vitapex paste is effective for middle-aged and elderly patients with combined periodontal-endodontic lesions

Zeng

2024

Am J Transl Res

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Objective: This study was designed to determine the efficacy of minocycline hydrochloride ointment (MHO) combined with Vitapex paste on middle-aged and elderly patients with combined periodontal-endodontic lesions (CPELs) and its effect on the inflammatory factors. Methods: The data of 88 elderly patients with CPELs treated in the First Affiliated Hospital of Gannan Medical University from March 2020 to March 2022 were analyzed retrospectively. Among them, the patients treated with MHO and iodoform zinc oxide clove oil paste were assigned into the control group (n = 42) and the rest of the patients treated by MHO and Vitapex paste were assigned to the study group (n = 46). The inflammatory factors, periodontal indexes and efficacy were determined and compared between the two groups. The MOS 36-Item Short-Form Health Survey (SF-36) was adopted to evaluate the quality of life (QoL) of patients before and after treatment. Additionally, the adverse reactions of the two groups during treatment were analyzed and compared. The prognosis of the two groups of patients was analysed, and factors impacting their prognosis was analysed through the Logistic regression analysis. Results: Before treatment, the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were not significantly different between the two groups (all P > 0.05), while after treatment, these levels in both groups decreased significantly, with notably lower levels in the study group than those in the control group (all P < 0.05). Before treatment, the gingival index (GI), plaque index (PLI), probing depth (PD) and bleeding index (BD) of the two groups were similar (all P > 0.05); however, after treatment, the levels of GI, PD, PLI and BI of both groups decreased significantly (all P < 0.05), with more notable decreases in the study group than those in the control group (all P < 0.05). The study group showed a significantly higher overall response rate than the control group (P < 0.05). Before treatment, the SF-36 scores of the two groups were not significantly different (P > 0.05), while after treatment, both groups had significantly increased SF-36 scores, and the score in study group was significantly higher than the control group (P < 0.05). In addition, the incidence of adverse reactions was not notably different between the two groups (P > 0.05). According to univariate analysis, age, dental lesion grade, course of disease, and persistent dull pain were the risk factors affecting the prognosis of patients. According to multivariate analysis, dental lesion grade was the independent risk factor affecting the prognosis. Conclusion: MHO combined with Vitapex paste is effective for middle-aged and elderly patients with CPELs, which can effectively inhibit the patients' inflammatory reaction and improve their periodontal condition and QoL, with a low adverse reaction rate, so it is worthy of clinical promotion.

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