In closed-loop control systems, the model accuracy exerts large influences on the controllability, stability and quality of the whole process. Among all the faults that could affect the system performance, Model Plant Mismatch (MPM) is the one that not only directly threatens the system stability but also deteriorates the controller performance. Meanwhile, MPM has a major influence on the qualities of outputs about industrial products. In this work, a new detection method based on Granger Causality is proposed to detect and locate the MPM in multiple input multiple output systems. Causality can reflect the relations between the mismatch fault and its negative effects on model predictive control(MPC) systems. With the assistance of disturbance transfer function models, the causality method can further be used to locate the mismatch positions and get the correct channels of each kind of mismatches. The proposed method was examined and validated in the Wood-Berry process in contrast to the decussation location method under model predictive controller.