Impact of modeled microgravity on migration, differentiation, and cell cycle control of primitive human hematopoietic progenitor cells

Simulated microgravity inhibits the migration of mesenchymal stem cells by remodeling actin cytoskeleton and increasing cell stiffness

“…The effect of microgravity or simulated microgravity on cell migration is not consistent among different reports. The reduced cell migration induced by microgravity or simulated microgravity correlated with a decrease of F-actin (Plett et al 2004;Li et al 2009;Meloni et al 2011), while extended expression of CXCR4 may mediate an increased BMSCs migration under simulated microgravity (Mitsuhara et al 2013). Particularly, Siamwala et al proposed that simulated microgravity perturbs actin polymerization to promote nitric oxideassociated migration of human Eahy926 cells (Siamwala et al 2010).…”

Exposure to modeled microgravity induces metabolic idleness in malignant human MCF‐7 and normal murine VSMC cells

“…Also Meyers et al [11] found that MMG alters proliferation rate, and reported that MMG, by decreasing integrin/MAPK signaling, contributes to reduced osteoblastogenesis during differentiation of human mesenchymal stem cells. Similarly, Plett et al [12] demonstrated that MMG causes alterations of human hematopoietic progenitor cells. Fig.…”

Microgravity may help future organ/tissue manufacture

“…Hypergravity induced MSCs to differentiate into forcesensitive cells such as osteoblasts and myocardial cells, however, microgravity may guide MSCs to force-insensitive cells such as adipocytes (Huang et al, 2009). As to HSCs, the migration of bone marrow CD34 + cells was significantly reduced under microgravity (Plett et al, 2004). The cycle was arrested at G0/G1 phase, thus the proliferation of hematopoietic precursors was inhibited by microgravity (Domaratskaya et al, 2002).…”