Impact of molecular subtypes classification concordance between preoperative core needle biopsy and surgical specimen on early breast cancer management: Single-institution experience and review of published literature

Meattini, Icro; Bicchierai, Giulia; Saieva, Calogero; Benedetto, Diego De; Desideri, Isacco; Becherini, Carlotta; Abdulcadir, D.; Vanzi, E.; Boeri, Cecilia; Gabbrielli, S; Lucci, Francesco; Sanchez, Luis; Casella, Donato; Bernini, Marco; Orzalesi, Lorenzo; Vezzosi, Vania; Greto, Daniela; Mangoni, Monica; Bianchi, Simonetta; Livi, Lorenzo; Nori, Jacopo

doi:10.1016/j.ejso.2016.10.025

Cited by 56 publications

(69 citation statements)

References 39 publications

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“…Identifying HER2-positive breast cancer patients by CNB is important, as neoadjuvant HER2-targeted therapy is an effective option for these patients. In this study, the CR for HER2 status, as determined by HER2 IHC or reflex HER2 SISH, was as high as 99.7% (kappa, 0.988), which was higher than most previous reports (ranging from 61%-97.3%) [10,[18][19][20][21][22][23][24][25][26][27][28][29]. The reason for this high CR could partially be due to performing reflex HER2 SISH for all HER2 IHC equivocal cases to determine final HER2 status strictly following ASCO/CAP guidelines.…”

Section: Discussioncontrasting

confidence: 58%

“…Consequently, assessing the concordance rate (CR) of marker status between CNB and surgical specimen is crucial [8,9]. It has been reported that CRs of biomarker status between CNB and surgi-cal specimen were high but variable: 79%-100% [10]. However, differences in Ki67 status according to manual or digital image analysis and the impact on subsequent molecular subtyping have not been adequately investigated.…”

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confidence: 99%

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Analysis of the molecular subtypes of preoperative core needle biopsy and surgical specimens in invasive breast cancer

Jeong

Kang

Lee

et al. 2020

J Pathol Transl Med

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Background: Accurate molecular classification of breast core needle biopsy (CNB) tissue is important for determining neoadjuvant systemic therapies for invasive breast cancer. The researchers aimed to evaluate the concordance rate (CR) of molecular subtypes between CNBs and surgical specimens. Methods: This study was conducted with invasive breast cancer patients who underwent surgery after CNB at Seoul St. Mary's Hospital between December 2014 and December 2017. Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki67 were analyzed using immunohistochemistry. ER and PR were evaluated by Allred score (0-8). HER2 was graded from 0 to +3, and all 2+ cases were reflex tested with silver in situ hybridization. The labeling index of Ki67 was counted by either manual scoring or digital image analysis. Molecular subtypes were classified using the above surrogate markers. Results: In total, 629 patients were evaluated. The CRs of ER, PR, HER2, and Ki67 were 96.5% (kappa, 0.883; p < .001), 93.0% (kappa, 0.824; p < .001), 99.7% (kappa, 0.988; p < .001), and 78.7% (kappa, 0.577; p < .001), respectively. Digital image analysis of Ki67 in CNB showed better concordance with Ki67 in surgical specimens (CR, 82.3%; kappa, 0.639 for digital image analysis vs. CR, 76.2%; kappa, 0.534 for manual counting). The CRs of luminal A, luminal B, HER2, and triple negative types were 89.0%, 70.0%, 82.9%, and 77.2%, respectively. Conclusions: CNB was reasonably accurate for determining ER, PR, HER2, Ki67, and molecular subtypes. Using digital image analysis for Ki67 in CNB produced more accurate molecular classifications.

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Section: Discussioncontrasting

confidence: 58%

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confidence: 99%

Analysis of the molecular subtypes of preoperative core needle biopsy and surgical specimens in invasive breast cancer

Jeong

Kang

Lee

et al. 2020

J Pathol Transl Med

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“…An advantage of modern genomic and molecular techniques is their potential for higher objectivity with a corresponding increase in reproducibility compared to subjective human eye histological grading. However, concordance of modern assays is showing no or marginal agreement . Because of technical ease, low cost, and in that grading does not consume additional tissue, grading could be considered to hold a unique advantage to molecular techniques.…”

Section: Discussionmentioning

confidence: 99%

“…However, concordance of modern assays is showing no or marginal agreement. 11,12,[21][22][23] Because of technical ease, low cost, and in that grading does not consume additional tissue, grading could be considered to hold a unique advantage to molecular techniques. Furthermore, with grading, discordance/ concordance discovery is feasible.…”

Section: Discussionmentioning

confidence: 99%

Impact of breast cancer grade discordance on prediction of outcome

et al. 2018

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“…Breast cancer is the third leading cause of cancer death in Japanese women . The most common histological type, invasive ductal carcinomas (IDC), frequently express hormone receptors (luminal subtype) and/or human epidermal growth factor receptor‐2 (HER2, Her2 subtype) . In contrast, approximately 15% of IDC express none of estrogen receptor (ER), progesterone receptor (PgR), or HER2, which is designated as triple‐negative breast cancer (TNBC) .…”

Section: Introductionmentioning

confidence: 99%

Targeting claudin‐4 enhances chemosensitivity in breast cancer

et al. 2020

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| INTRODUC TI ONBreast cancer is the third leading cause of cancer death in Japanese women. 1 The most common histological type, invasive ductal carcinomas (IDC), frequently express hormone receptors (luminal subtype) and/or human epidermal growth factor receptor-2 (HER2, Her2 subtype). 2,3 In contrast, approximately 15% of IDC express none of estrogen receptor (ER), progesterone receptor Abstract Triple negative breast cancer (TNBC) is characterized by highly aggressive phenotype, limited treatment options and a poor prognosis. In the present study, we examined the therapeutic effect of anti-claudin (CLDN)-4 extracellular domain antibody, 4D3, on TNBC. When the expression of CLDN4 and CLDN1 in invasive ductal carcinoma (IDC) was examined in 114 IDC (78 cases from 2004 to 2009 in a single center and 36 cases of tissues array), CLDN1 had lower expression than CLDN4 and was correlated with histological grade. In contrast, expression of CLDN4 was correlated with histological grade, receptor subtype, and stage. CLDN4 expression in human IDC cell lines MCF-7 (luminal subtype) and MDA-468 (TNBC) was at the same level. In both cells, paclitaxel (PTX)-induced growth suppression was enhanced by 4D3. Furthermore, 4D3 increased both intracellular PTX concentration (in both cells) and apoptosis. In the mouse model, 4D3 promoted the antitumor effect of PTX on subcutaneous tumors and reduced lung metastasis. The combination of PTX and 4D3 reduced M2 macrophages and mesenchymal stem cells in the tumor. 4D3 also reduced stemness of the tumors and increased the intratumoral pH. Moreover, concurrent treatment with 4D3, PTX and tamoxifen, or with PTX and tamoxifen in MDA-468 also showed the same level of antitumor activity and survival as MCF-7. Furthermore, in a bone metastasis model, combination of PTX and bisphosphonate with 4D3 promoted tumor growth in both cells. Thus, CLDN4 targeting of the antibody facilitated existing therapeutic effects. K E Y W O R D S breast cancer, chemotherapy, claudin, microenvironment, tight junction | 1841 LUO et aL.

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Impact of molecular subtypes classification concordance between preoperative core needle biopsy and surgical specimen on early breast cancer management: Single-institution experience and review of published literature

Cited by 56 publications

References 39 publications

Analysis of the molecular subtypes of preoperative core needle biopsy and surgical specimens in invasive breast cancer

Analysis of the molecular subtypes of preoperative core needle biopsy and surgical specimens in invasive breast cancer

Impact of breast cancer grade discordance on prediction of outcome

Targeting claudin‐4 enhances chemosensitivity in breast cancer

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