Impact of monocyte to high-density lipoprotein ratio on prevalent hyperuricemia: findings from a rural Chinese population

Chen, Meng-Qi; Shi, Wenrui; Shi, Chuning; Zhou, Yaping; Sun, Yingxian

doi:10.1186/s12944-020-01226-6

Cited by 12 publications

(11 citation statements)

References 49 publications

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“…The process about data collection and measurements was fully described in our previously published studies [ 17 ]. Before the survey, cardiologists and nurses participated a professional training, passed a standardized exam, and acquired the qualification to gather data.…”

Section: Methodsmentioning

confidence: 99%

Combined effect of hypertension and hyperuricemia on ischemic stroke in a rural Chinese population

et al. 2021

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Background To investigate the combined effect of hypertension and hyperuricemia to the risk of ischemic stroke in a rural Chinese population. Methods The cross-sectional study was conducted from 2012 to 2013 in a rural area of China. After exclusion for missing data, we finally included 11,731 participants into analysis. Results After adjusting for age, current smoking, current drinking, BMI, TG, HDL-C and eGFR, hypertension was significantly associated with ischemic stroke in men (OR: 2.783, 95% CI: 1.793, 4.320) and in women (OR: 4.800, 95% CI: 2.945, 7.822). However, hyperuricemia was significantly associated with ischemic stroke only in women (OR: 1.888, 95% CI: 1.244, 2.864). After full adjustment, participants with both hypertension and hyperuricemia had 8.9 times higher risk than those without them. Finally, the interaction between hypertension and hyperuricemia was statistically significant only in women rather than in men after full adjustment. Conclusions This study demonstrated the positive correlations between hypertension, hyperuricemia and ischemic stroke. Our study also demonstrated the joint effect between hypertension and hyperuricemia towards ischemic stroke only in women, not in men.

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Section: Methodsmentioning

confidence: 99%

Combined effect of hypertension and hyperuricemia on ischemic stroke in a rural Chinese population

et al. 2021

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“…Detailed information about NCRCHS has been extensively described elsewhere. 22 Participants had attended face-to-face interviews and examinations. Of the 11,956 subjects whose data were used in the NCRCHS, individuals under the age of 35 years and those with incomplete biochemical data were excluded from the present study.…”

Section: Participants and Methodsmentioning

confidence: 99%

“…Details of data collection were presented in our previous works. 22 Briefly, cardiologists and nurses participated in a training course, passed a uniform exam, and obtained the qualification to collect information through self-administered questionnaires. The information was about demographic data, anthropometric parameters, and health-related behaviors.…”

Section: Participants and Methodsmentioning

confidence: 99%

Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China

Chen

Shi

Wang

et al. 2021

DMSO

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Purpose Some studies have established an association between hypertension or obesity and the risk of diabetes. This study aimed to examine the interaction of hypertension and obesity on diabetes. Participants and Methods The data of 11,731 Chinese men and women were analyzed from the 2012–2013 Northeast China Rural Cardiovascular Health Study. The interaction was examined by both additive and multiplicative scales. General obesity was measured by body mass index (BMI); central obesity was defined by waist circumference (WC), waist-to-height ratio (WHtR) and waist-to-hip ratio (WHpR). Results After controlling for potential confounders, the odds ratios for diabetes were 3.864 (3.205–4.660), 4.500 (3.673–5.514), 4.932 (3.888–6.255) and 4.701 (3.817–5.788) for the combinations of hypertension and BMI, WC, WHtR or WHpR, respectively, which had the highest risk of diabetes among the four combinations. Notwithstanding the multiplicative interactions showed statistically significant in all analyses, the results of additive interactions were not consistent, suggesting the diabetes risk from female BMI (relative excess risk due to interaction (RERI): 1.136, 95% CI: 0.127–2.146, attributable proportion due to interaction (AP): 0.267, 95% CI: 0.057–0.477, synergy index (S):1.536, 95% CI: 1.017–2.321) or female WHpR (RERI: 1.076, 95% CI: 0.150–2.002, AP:0.205, 95% CI: 0.037–0.374, S:1.340, 95% CI: 1.012–1.775) was additive to the risk from hypertension. Conclusion The findings suggest that high BMI and high WHpR have synergistic interactions with hypertension on the risk of diabetes for females. The results of this study also suggest that BMI and WHpR, rather than WC, should be used for the diagnosis of metabolic syndrome in Chinese population.

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“…Detailed design about NCRCHS has been fully described elsewhere. 17 Subjects (age ≥35 years) had participated in face-to-face interviews and health examinations. Of the 11,956 individuals whose data were used in the 2012–2013 NCRCHS, participants with incomplete biochemical and clinical data were excluded from our study.…”

Section: Methodsmentioning

confidence: 99%

Sex Differences of Combined Effects Between Hypertension and General or Central Obesity on Ischemic Stroke in a Middle-Aged and Elderly Population

Chen¹,

Shi²,

Wang³

et al. 2021

CLEP

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Background Hypertension and obesity are recognized as modifiable risk factors for stroke, but their combined effects are unknown. This study aimed to explore the combined effects of hypertension and general or central obesity on the risk of ischemic stroke in a middle-aged and elderly population. Methods The data of 11,731 participants (53.5 ± 10.5 years old) were analyzed from the Northeast China Rural Cardiovascular Health Study, 2012–2013. General obesity (GO) was defined by body mass index (BMI); central obesity (CO) was measured by waist circumference (WC), waist-to-height ratio (WHtR) and waist-to-hip ratio (WHpR). Results The overall prevalence of ischemic stroke was 3.1%. After adjusting for age and sex, the odds ratios for having ischemic stroke were 4.31 (3.14–5.91) among subjects with hypertension, 1.79 (1.40–2.30) with GO, 1.94 (1.54–2.43), 1.98 (1.54–2.53), and 1.65 (1.33–2.06) with CO measured by WC, WHtR and WHpR, respectively. After full adjustment for potential confounders, the combinations of hypertension and obesity indices (including BMI, WC, WHtR and WHpR) were associated with the highest risk of ischemic stroke, especially in women, which were respectively 7.3-fold, 9.3-fold, 9.9-fold and 7.6-fold higher than that of individuals without both conditions. Conclusion Our study results suggest that women with both hypertension and obesity, no matter defined by BMI, WC, WHtR or WHpR, were more likely to have ischemic stroke. A better understanding of the combined effects of these risk factors can help promote primary prevention in susceptible subgroups.

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Impact of monocyte to high-density lipoprotein ratio on prevalent hyperuricemia: findings from a rural Chinese population

Cited by 12 publications

References 49 publications

Combined effect of hypertension and hyperuricemia on ischemic stroke in a rural Chinese population

Combined effect of hypertension and hyperuricemia on ischemic stroke in a rural Chinese population

Interaction of General or Central Obesity and Hypertension on Diabetes: Sex-Specific Differences in a Rural Population in Northeast China

Sex Differences of Combined Effects Between Hypertension and General or Central Obesity on Ischemic Stroke in a Middle-Aged and Elderly Population

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