Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice

Melebary, Sahar J.; Elnaggar, Moustafa H.R.

doi:10.1016/j.sjbs.2022.103507

Cited by 8 publications

(4 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This mechanism of action of polyphenols contained in Moringa oleifera leaf extract is in parallel with the findings of the included literature. Some studies showed that there is significant reduction of blood glucose level and improvement of insulin sensitivity measured in group of animals treated by Moringa oleifera leaf extract [ 29 , 33 , 36 , 37 , 49 ]. From the studies included, we conclude that dosage of Moringa oleifera leaf extract of more than 200 mg/kg body weight showed more significant result of glucose and insulin profile than the lower dosage [ 29 , 33 , 36 , 37 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…Most of the studies provide explanation of the resulting effects of Moringa oleifera leaf extract on lipid profile. The collected data of included literatureexplained that Moringa oleifera leaf extract provided significant reduction of triglyceride, LDL-C, VLDL-C, and cholesterol in group fed by Moringa oleifera leaf extract [ 29 , 33 , 35 , 36 , 49 ]. Besides that, included literature also stated that there is an improvement of HDL-C in lipid profile of group fed by Moringa oleifera leaf extract [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies included also measured liver injury biomarkers as other findings besides liver histopathological features. These studies stated that there is significant reduction on the AST, ALT, ALP, SGOT, and SGPT in the group of animals treated by Moringa oleifera leaf extract [ 29 – 31 , 33 – 36 , 40 , 41 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Moringa oleifera Leaf Extract on Liver Histopathology: A Systematic Review

Nurhayati,

Ridho,

Santoso

et al. 2024

Journal of Nutrition and Metabolism

View full text Add to dashboard Cite

Introduction. Moringa leaves (Moringa oleifera), which are members of the Moringaceae family, are one of the herbal plants that are widely known in Indonesia. Phytochemical contents of moringa leaf, such as flavonoid, quercetin, and phenolic acid, are believed to have an effect on improvement of NAFLD. Therefore, moringa leaf is considered as one the herbal plants that can be used as supplementation in the form of adjuvant therapy to NAFLD. The study objective of our research is to review the effect of giving moringa leaf to the liver, especially the histopathologic features. This study will be conducted on literature review research design, more specifically in the form of a systematic review. Research Method. Five major electronic web databases, including PubMed, Cochrane Library, Google Scholar, Scopus, and ScienceDirect, were used in identifying literature from 2014 to 2023. Results. From a comprehensive analysis of 13 relevant literature sources, we elucidate the impact of Moringa oleifera leaf extract on liver histopathology, glucose, and lipid metabolism. Furthermore, we provide insights into its safety profile concerning human health. Conclusion. The phytochemical content of Moringa oleifera leaf extract had shown a significant benefit in plant medicinal sector. From the research that had been done, Moringa oleifera leaf extract contributes to give significant improvement on liver histopathological features, glucose, and lipid metabolism on animal sample model.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Moringa oleifera Leaf Extract on Liver Histopathology: A Systematic Review

Nurhayati,

Ridho,

Santoso

et al. 2024

Journal of Nutrition and Metabolism

View full text Add to dashboard Cite

show abstract

“…These cytokines play a vital role in the development of toxicity, as commonly demonstrated in animal models. The expression of inflammatory mediators and the generation of pro-inflammatory cytokines (including TNF-α and IL-1β) are facilitated by the activation of NF-kB in the hepatocellular nucleus, which in turn leads to inflammation and apoptosis and might produce ROS [ 61 ]. As a result, NF-kB is widely established as a key modulator of cellular necrosis and inflammation [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Antagonistic effectiveness of Anacardium occidentale leaf extract on lead-acetate exposure-induced hepatorenal toxicity in rats

Aminu,

Umar,

Makena

et al. 2023

Environ Anal Health Toxicol

View full text Add to dashboard Cite

Lead (Pb) poisoning is an environmental substance that accumulates in the hepato-renal tissue, which is hazardous to health, while Anacardium occidentale L. is a tropical herb used to treat oxidative stress and inflammatory diseases. The aim of this study was to investigate the antagonistic effect of Anacardium occidentale leaf extract on lead acetate exposure-induced hepatorenal toxicity in rats. Thirty-six adult Wistar rats were split into six equal groups (n = 6). Group I served as a control, and groups II and III were administered lead acetate (50 mg/kg) and Anacardium occidentale leaf extract (400 mg/kg), respectively, while rats in groups IV–VI were administered Anacardium occidentale (L) extract (200 mg/kg and 400 mg/kg) and 10 mg/kg of Succimer, respectively, and were then administered lead acetate (50 mg/kg). When compared to the group I, rats administered lead acetate showed an increase in hepatic enzymes, urea, creatinine, MDA, TNF-α, and IL-1β (p < 0.001) levels and decreased levels of SOD, CAT, and GSH, whereas Anacardium occidentale prevented the increase in hepatorenal function parameters, oxidative stress, and inflammatory markers (TNF-α and IL-1β) induced by lead acetate. Rats administered only lead acetate had a marked increase in hepatic Pb concentration, severe hepatic steatosis, and renal glomerulus degeneration. However, treatment with Anacardium occidentale extract and succimer decreases the Pb concentration, oxidative stress, and inflammation, and also reduces histological liver steatosis and glomerular cytoarchitecture deterioration in the kidney. The results of this study revealed that Anacardium occidentale extract protects against lead acetate-induced liver and kidney toxicity by decreasing oxidative stress and inflammation.

show abstract

Lead: Exposure Risk, Bio Assimilation and Amelioration Strategies in Livestock Animals

Singh¹,

Mahesh²,

Ojha

et al. 2023

Environmental Science and Engineering

View full text Add to dashboard Cite

Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice

Cited by 8 publications

References 64 publications

Effects of Moringa oleifera Leaf Extract on Liver Histopathology: A Systematic Review

Effects of Moringa oleifera Leaf Extract on Liver Histopathology: A Systematic Review

Antagonistic effectiveness of Anacardium occidentale leaf extract on lead-acetate exposure-induced hepatorenal toxicity in rats

Lead: Exposure Risk, Bio Assimilation and Amelioration Strategies in Livestock Animals

Contact Info

Product

Resources

About