Impact of Mycotoxins on Human Health

Freire, F. das C. O.; Rocha, Maria Edite Bezerra da

doi:10.1007/978-3-319-25001-4_21

Cited by 23 publications

(18 citation statements)

References 80 publications

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“…To date, the world still desires for a more accurate evidence-based on mycotoxins and human health, as well as a better biomarker of exposure and data from studies of disease distribution. Current data are valid to justify and respond to reduce exposure in vulnerable populations (Freire and da Rocha, 2017 ). The implementation of more practical and affordable mycotoxin removal techniques at the household level to effectively reduce exposure are becoming increasingly important.…”

Section: Introductionmentioning

confidence: 99%

Mycotoxin: Its Impact on Gut Health and Microbiota

Liew

Sabran

2018

Front. Cell. Infect. Microbiol.

336

195

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The secondary metabolites produced by fungi known as mycotoxins, are capable of causing mycotoxicosis (diseases and death) in human and animals. Contamination of feedstuffs as well as food commodities by fungi occurs frequently in a natural manner and is accompanied by the presence of mycotoxins. The occurrence of mycotoxins' contamination is further stimulated by the on-going global warming as reflected in some findings. This review comprehensively discussed the role of mycotoxins (trichothecenes, zearalenone, fumonisins, ochratoxins, and aflatoxins) toward gut health and gut microbiota. Certainly, mycotoxins cause perturbation in the gut, particularly in the intestinal epithelial. Recent insights have generated an entirely new perspective where there is a bi-directional relationship exists between mycotoxins and gut microbiota, thus suggesting that our gut microbiota might be involved in the development of mycotoxicosis. The bacteria–xenobiotic interplay for the host is highlighted in this review article. It is now well established that a healthy gut microbiota is largely responsible for the overall health of the host. Findings revealed that the gut microbiota is capable of eliminating mycotoxin from the host naturally, provided that the host is healthy with a balance gut microbiota. Moreover, mycotoxins have been demonstrated for modulation of gut microbiota composition, and such alteration in gut microbiota can be observed up to species level in some of the studies. Most, if not all, of the reported effects of mycotoxins, are negative in terms of intestinal health, where beneficial bacteria are eliminated accompanied by an increase of the gut pathogen. The interactions between gut microbiota and mycotoxins have a significant role in the development of mycotoxicosis, particularly hepatocellular carcinoma. Such knowledge potentially drives the development of novel and innovative strategies for the prevention and therapy of mycotoxin contamination and mycotoxicosis.

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Section: Introductionmentioning

confidence: 99%

Mycotoxin: Its Impact on Gut Health and Microbiota

Liew

Sabran

2018

Front. Cell. Infect. Microbiol.

336

195

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“…Most of the mycotoxin are found as natural contaminant food, mainly in vegetable and feed. Nut, cereals, oilseeds, dried fruits, spices, and food from animal origins for example milk, egg, and meat are also may contain mycotoxin either outside or inside the product [10,11]. A mycotoxin is believed no function in the life of a producer cell, unlike primary metabolites [12].…”

Section: Mycotoxinmentioning

confidence: 99%

Recent Biosensors Technologies for Detection of Mycotoxin in Food Products

Rovina¹,

Shaeera²,

Vonnie³

et al. 2020

Mycotoxins and Food Safety

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Mycotoxins are chemically diverse and capable of inducing a wide diversity of acute and chronic symptoms, ranging from feed refusal to rapid death. Accurate detection and monitoring of mycotoxins is an essential component of the prevention, diagnosis, and remediation of mycotoxin-related issues in livestock and human food. Current trends in food analysis are focusing on the application of fast, simple procedure needed, and low-cost biosensor technologies that can detect with high sensitivity and selectivity different compounds associated with food safety. This chapter discussed the recent analytical methods-based biosensor technology for quantification of mycotoxins in food products. Mainly focus on the biosensor technology based on the immobilization of antibodies onto various nanomaterials such as nanoparticles, graphite, carbon nanotubes, and quantum dots. The nanomaterials are able to be functionalized with various biomolecules such as enzymes, antibodies, nucleic acids, DNA/RNA aptamers, bio-or artificial receptors that make them suitable for detection of various substances such as food toxins, bacteria, and other compounds important in food analysis. All the nanomaterials provide an effective platform for achieving high sensitivity that is similar and, in some cases, even better than conventional analytical methods. We believe that future trends will be emphasized on improving biosensor properties toward practical application in the food industry.

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“…Table lists examples of the grains affected by these mycotoxins and their potential impact on human health. Maize, wheat and barley are primarily affected by all mycotoxins, with adverse effects in humans including nausea and fever, and potentially cancer (Freire & da Rocha ).…”

Section: Contaminants In Wholegrainsmentioning

confidence: 99%

Wholegrains and health: Many benefits but do contaminants pose any risk?

Nugent

Thielecke

2019

Nutrition Bulletin

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Since pre‐historic times, humans have consumed grains as part of their diet. Being rich in carbohydrates, grains typically form a key part of all food‐based dietary guidelines, with wholegrains recommended as healthy dietary choices. However, grains are also exposed to contaminants from air, soil, water, insects, animals, microbes, humans, storage and shipping containers, and handling and processing equipment and can be one of the main dietary sources of food‐borne contaminants by virtue of their frequent consumption. Recent scientific reports positively highlight wholegrains as foods with inherent health properties, which, because they provide fibre and micronutrients such as B vitamins and zinc, can improve the quality of carbohydrate intake as part of sustainable, healthy diets. This article describes potential health‐protective properties inherent to wholegrains and contends that the presence of contaminants in wholegrains, including mycotoxins, heavy metals and acrylamide, merits continued monitoring but that any such risk does not outweigh the known benefits of wholegrain consumption.

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Impact of Mycotoxins on Human Health

Cited by 23 publications

References 80 publications

Mycotoxin: Its Impact on Gut Health and Microbiota

Mycotoxin: Its Impact on Gut Health and Microbiota

Recent Biosensors Technologies for Detection of Mycotoxin in Food Products

Wholegrains and health: Many benefits but do contaminants pose any risk?

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