Impact of naevus association on survival for nodular and superficial spreading melanomas

Vu, Mi; Adler, Nikki R; Wee, Edmund; Wolfe, Rory; McLean, Catriona; Kelly, John W.; Pan, Yue

doi:10.1111/bjd.16556

Cited by 3 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, when compared with NAM, de novo melanoma was not associated with a higher risk for melanoma‐specific death. There are reports of no differences in MSS for NAM compared with de novo melanoma, 33,34 whereas in the study by Cymerman et al . de novo melanoma was an independent factor predicting worse overall survival in one of the two patient cohorts studied 22 .…”

Section: Discussionmentioning

confidence: 87%

A multicentre study of naevus‐associated melanoma vs. de novo melanoma, tumour thickness and body site differences*

et al. 2021

View full text Add to dashboard Cite

Background Whether melanoma in histological contiguity with a naevus [naevusassociated melanoma (NAM)] is distinctly different from melanoma arising de novo remains unclear. Objectives To determine whether the characteristics of de novo melanoma differ from NAM and are not due to naevus obliteration in thicker tumours. Methods We conducted a multicentre retrospective study of de novo melanoma and NAM in seven referral centres in Europe, Australia and the USA between 2006 and 2015. Results In a total of 9474 localized melanomas, de novo melanoma was associated with thicker tumours and body site differences compared with NAM. In the subset of T 1 melanomas (n = 5307), similar body site differences were found in multivariate analysis by body site. When compared with NAM, de novo melanoma was more likely to affect older individuals (≥ 70 years) when located on the head/neck [odds ratio (OR) 4Á65, 95% confidence interval (CI) 2Á55-8Á46], the trunk (OR 1Á82, 95% CI 1Á40-2Á36) or the upper extremity (OR 1Á69, 95% CI 1Á14-2Á50), was more likely to affect female patients when located on the lower extremities (OR 1Á36, 95% CI 1Á03-1Á80), and was more likely to be of the nodular melanoma subtype (OR 2Á23, 95% CI 1Á14-4Á35) when located on the trunk. De novo melanoma was less likely to have regression present compared with NAM.

show abstract

Section: Discussionmentioning

confidence: 87%

A multicentre study of naevus‐associated melanoma vs. de novo melanoma, tumour thickness and body site differences*

et al. 2021

View full text Add to dashboard Cite

show abstract

“…There are conflicting findings in the survival of de novo vs. NAM, although most studies showed no effect of the nevus association after multivariate adjustment for factors known to affect survival such as Breslow thickness and ulceration 12,13,18,38 (Table 2). In one study, Cymerman et al.…”

Section: Epidemiological Clinical and Histologic Characteristics Of N...mentioning

confidence: 99%

“…These findings suggest that nevi tend to give rise to SSM subtype. 13,20,21,25,28,29,[35][36][37] Regarding the presence of a nevus in histological association with NM, nevus remnants have been described in some of the cases of nodular melanomas in all the available studies, albeit in significantly lower frequency compared to SSM 10,12,13,15,[18][19][20]22,[25][26][27][28][29]34,38 (Table 1). Regarding LMM, no case of nevus remnants was reported in LMM in some studies, 26,29,32 while others have reported the presence of nevus remnants in a small number of LMMs.…”

Section: Introductionmentioning

confidence: 99%

“…Higher nevus counts have been associated with NAM compared to de novo melanoma, supporting that NAM development may be mediated by a divergent pathway. 12,19,24,28 There are conflicting findings in the survival of de novo vs. NAM, although most studies showed no effect of the nevus association after multivariate adjustment for factors known to affect survival such as Breslow thickness and ulceration 12,13,18,38 (Table 2). In one study, Cymerman et al found that de novo melanoma was an independent factor predicting worse overall survival in one of the two patient cohorts studied.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A review of nevus‐associated melanoma: What is the evidence?

Dessinioti

Geller

Stratigos

2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

Cutaneous melanoma may have an adjacent nevus remnant on histological examination in 30% of cases (nevusassociated melanoma, NAM), while it may appear de novo, without a precursor lesion, in the remaining 70% of cases.Nevus-associated melanoma and the concept of acquired melanocytic nevi serving as precursors of melanoma has long been considered as a controversial topic. This controversy is, in part, due to their overall low rate of transformation to melanoma and scarce data on the natural history of progression. Another matter of debate regarded the possibility that the reported differences in NAM vs. de novo melanoma were due to an underestimation of NAM in thicker lesions due to obliteration of the nevus component by the tumour. During the last few years, several evidence has accumulated in order to address these controversies. In this review, we present a comprehensive synthesis of the epidemiological, clinical, dermoscopic and genetic findings in NAM, including thin NAM, compared to de novo melanoma. Answering the questions on nevus-associated melanoma may provide further insight into the classification of these tumours and disentangle their biology and route of development from that of de novo melanoma.

show abstract