Impact of nanostructured lipid carriers on dapsone delivery to the skin: in vitro and in vivo studies

Elmowafy, Mohammed; Shalaby, Khaled; Ali, Hazim M.; Alruwaili, Nabil K.; Salama, Ayman; Ibrahim, Mohamed F.; Akl, Mohamed A.; Ahmed, Tarek A.

doi:10.1016/j.ijpharm.2019.118781

Cited by 39 publications

(41 citation statements)

References 47 publications

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“…For example, liquid lipid percentage increases in case of multiple emulsion NLC ( Khosa, Reddi, and Saha 2018 ). Also higher encapsulation efficiencies with higher oil percentages have been recently reported by Elmowafy and coworkers in case of the drug is very soluble in oil as higher oil percentages created sufficient spaces for accommodation of lipophilic drugs in lipid matrix ( Elmowafy et al 2019 ). In addition, faster drug release was observed with higher liquid lipid content by Fathi and coworkers ( Fathi et al 2018 ).…”

Section: Components and Formulation Attributesmentioning

confidence: 83%

Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Elmowafy

Al‐Sanea

2021

Saudi Pharmaceutical Journal

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168

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NLCs have provoked the incessant impulsion for the development of safe and valuable drug delivery systems owing to their exceptional physicochemical and then biocompatible characteristics. Throughout the earlier period, a lot of studies recounting NLCs based formulations have been noticeably increased. They are binary system which contains both solid and liquid lipids aiming to produce less ordered lipidic core. Their constituents particularly influence the physicochemical properties and effectiveness of the final product. NLCs can be fabricated by different techniques which are classified according to consumed energy. More utilization NLCs is essential due to overcome barriers surrounded by the technological procedure of lipid-based nanocarriers’ formulation and increased information of the core mechanisms of their transport via various routes of administration. They can be used in different applications and by different routes such as oral, cutaneous, ocular and pulmonary. This review article seeks to present an overview on the existing situation of the art of NLCs for future clinics through exposition of their applications which shall foster their lucid use. The reported records evidently demonstrate the promise of NLCs for innovate therapeutic applications in the future.

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Section: Components and Formulation Attributesmentioning

confidence: 83%

Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Elmowafy

Al‐Sanea

2021

Saudi Pharmaceutical Journal

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168

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“…The particle size and zeta potential are key elements for estimation of the stability of the colloidal delivery system during storage [ 30 ]. Additionally, both parameters also were reported to affect cutaneous drug delivery across skin barrier [ 31 , 32 ]. Table 1 shows the particle size and zeta potential of all investigated formulations.…”

Section: Resultsmentioning

confidence: 99%

Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability

et al. 2021

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The main objective of this study was to prepare and characterize oleogel as potential carrier for quercetin skin delivery. The formulations were prepared by adding olive oil (5–30%) to Pluronic F127 hydrogel and were evaluated for particle size, zeta potential, viscosity in vitro quercetin release and stability, and were compared with that of Pluronic F127 hydrogel. The selected formulation was characterized for its interaction possibility, ex vivo skin permeation and skin histological changes and safety. The particle sizes ranged from 345.3 ± 5.3 nm to 401.5 ± 2.8 nm, and possessed negative charges. The viscosities of the formulations were found in the range of 6367–4823 cps with inverse proportionality to olive oil percentage while the higher percentages showed higher quercetin release. Percentages of 25% and 30% olive oil showed instability pattern under the conditions of accelerated stability studies. Differential scanning calorimetry verified the existence of quercetin in micellar aggregation and the network in the case of hydrogel and oleogel respectively. Ex vivo skin permeation showed an improved skin permeation of quercetin when 20% olive oil containing oleogel was used. Skin histology after 10 days of application showed stratum corneum disruption and good safety profile. Based on these findings, the proposed oleogel containing 20% olive oil denotes a potential carrier for topical delivery of quercetin.

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“…An in vitro skin penetration assay is one way to predict drug penetration in vivo and has been validated by in vitro – in vivo correlation studies (Elmowafy et al., 2019 ). The amount of skin penetration in the NIR-stimulated group was 125.11 ± 8.58 μg/cm 2 , which was 2.3 times higher than the control, indicating that JR400-MoS 2 NPs are suitable for TDDS applications ( Figure 8(b) ).…”

Section: Resultsmentioning

confidence: 99%

Functionalized MoS ₂ -nanoparticles for transdermal drug delivery of atenolol

et al. 2020

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Molybdenum disulfide (MoS 2 ) has excellent photothermal conversion abilities, an ultra-high specific surface area, and has been extensively explored for use in biomedicine. However, the high toxicity associated with MoS 2 has limited its biological applications for in vivo photothermal therapy and drug delivery systems. Herein, we have developed cationic hydroxyethyl cellulose (JR400) surface-modified MoS 2 nanoparticles (NPs) that are responsive to near-infrared (NIR) laser irradiation as a transdermal drug delivery system (TDDS). Herein, we confirmed the preparation of hexagonal phase MoS 2 with robust surface modification with JR400. The flower-like morphology of the NPs had an average diameter of 355 ± 69.3 nm limiting the absorption of the NPs through the stratum corneum. With the ability to efficiently load 90.4 ± 0.3% of the model drug atenolol (ATE), where 1 g of JR400-MoS 2 NPs was able to load 3.6 g ATE, we assayed the controlled release capacity in vitro skin penetration studies. These JR400-MoS 2 NPs showed further enhancement under NIR stimulation, with a 2.3-fold increase in ATE skin penetration. Furthermore, we verified in vivo that these JR400-MoS 2 NPs do not cause skin irritation suggesting that they are promising new TDDS candidates for small molecule drugs.

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Impact of nanostructured lipid carriers on dapsone delivery to the skin: in vitro and in vivo studies

Cited by 39 publications

References 47 publications

Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability

Functionalized MoS ₂ -nanoparticles for transdermal drug delivery of atenolol

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Impact of nanostructured lipid carriers on dapsone delivery to the skin: in vitro and in vivo studies

Cited by 39 publications

References 47 publications

Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability

Functionalized MoS 2 -nanoparticles for transdermal drug delivery of atenolol

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Product

Resources

About

Functionalized MoS ₂ -nanoparticles for transdermal drug delivery of atenolol