“…In that study, long term treatment with nebulized sildenafil was provided, and the responses regarding improvement in asthma pathology were found better with all three different doses of nebulized sildenafil compared to placebo and even nebulized steroid. 15 de Visser et al used sildenafil treatment in experimental bronchopulmonary dysplasia (BPD). 31 Sildenafil treatment, started simultaneously with exposure to hyperoxia after birth, prolonged survival, increased pulmonary cGMP levels, reduced the pulmonary inflammatory response, fibrin deposition and right ventricular hypertrophy, and stimulated alveolarization.…”