2010
DOI: 10.5336/medsci.2008-9111
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Impact of Nebulized Sildenafil on Lung Histology in a Murine Model of Chronic Asthma

Abstract: A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Sil de na fil, which is used for the tre at ment of erec ti le dysfunc ti on, has be en shown to in hi bit inf lam ma ti on in an ani mal mo del of ast hma. We ai med to de ter mi ne the im pact of ne bu li zed sil de na fil on lung his to logy in a mu ri ne mo del of chro nic ast hma. M Ma at te er ri ia al l a an nd d M Me et t h ho od ds s: : Forty-two BALB/c mi ce we re di vi ded in to six gro ups; A, B, C, D, E, and the con trol group. All gro up… Show more

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(3 citation statements)
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“…In that study, long term treatment with nebulized sildenafil was provided, and the responses regarding improvement in asthma pathology were found better with all three different doses of nebulized sildenafil compared to placebo and even nebulized steroid. 15 de Visser et al used sildenafil treatment in experimental bronchopulmonary dysplasia (BPD). 31 Sildenafil treatment, started simultaneously with exposure to hyperoxia after birth, prolonged survival, increased pulmonary cGMP levels, reduced the pulmonary inflammatory response, fibrin deposition and right ventricular hypertrophy, and stimulated alveolarization.…”
Section: Discussionmentioning
confidence: 99%
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“…In that study, long term treatment with nebulized sildenafil was provided, and the responses regarding improvement in asthma pathology were found better with all three different doses of nebulized sildenafil compared to placebo and even nebulized steroid. 15 de Visser et al used sildenafil treatment in experimental bronchopulmonary dysplasia (BPD). 31 Sildenafil treatment, started simultaneously with exposure to hyperoxia after birth, prolonged survival, increased pulmonary cGMP levels, reduced the pulmonary inflammatory response, fibrin deposition and right ventricular hypertrophy, and stimulated alveolarization.…”
Section: Discussionmentioning
confidence: 99%
“…Heart rates and SaO 2 were measured by pulse oxymeter (Nellcor N595) just before (0 minute) and five minutes after each dose of methacholine. 18 Ten minutes after the last methacholine dose, nebulized sildenafil (0.07 mg/ml), 15,19 nebulized budesonide (0.25 mg/ml), 20 and nebulized saline were given to Group 3, 4 and 5 respectively for 15 minutes. SaO 2 and heart rates were also obtained 15 minutes after the nebulized therapies.…”
Section: Sensitization and Inhalational Exposurementioning
confidence: 99%
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