Impact of negative lymph nodes on colon cancer survival and exploring relevant transcriptomics differences through real-world data analyses

Hao, Yuying; Zhang, Jiandong; Du, Rui; Huang, Xinyi; Li, Hui; Hu, Pingping

doi:10.21037/atm.2019.09.138

Cited by 5 publications

(8 citation statements)

References 27 publications

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“…The different biological processes between the high and low NLN group through transcriptomic analysis (14).…”

Section: Discussionmentioning

confidence: 99%

Negative lymph node count is an independent prognostic factor for female patients with node positive breast cancer

Wu¹,

Huang²

2020

Transl Cancer Res TCR

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Background: Negative lymph node (NLN) count has been reported to associate with the prognosis of various cancers. This study aims to reveal the prognostic value of NLN count in breast cancer.Methods: Clinical characteristics of patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database. The X-tile program was used to determine the optimal cutoffs for NLN count.Univariate and multivariate analysis were used to assess the risk factors for breast cancer-specific survival (BCSS).Results: The X-tile program identified that cutoff value of 2 and 10 could divide the patients into high, middle and low risk subgroups. According to multivariate analysis, patients with NLN count ≤1, over 60 years old, being black, higher tumor grade, higher T or N stage, negative hormone receptor, no radiotherapy or no chemotherapy would more likely suffer poor survival outcome. Subgroup analysis showed that NLN count could still predict survival independently.Conclusions: NLN count is a potentially effective predictor of breast cancer and is a good supplement for N stage and TNM stage. Combining NLN count with other prognostic factors will be a better predictor for the survival of breast cancer patients.

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“…The different biological processes between the high and low NLN group through transcriptomic analysis (14).…”

Section: Discussionmentioning

confidence: 99%

Negative lymph node count is an independent prognostic factor for female patients with node positive breast cancer

Wu¹,

Huang²

2020

Transl Cancer Res TCR

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“…In patients with nonmetastatic colon cancer, the higher the number of harvested lymph nodes, the better the oncological prognosis. The ratio of the involved lymph nodes to the harvested lymph nodes was identified as a strong prognostic indicator in stage III patients [ 64 , 65 ]. Although it is true that the removal of more lymph nodes by extended radical lymph node dissection is reflecting favorable prognosis, it requires considerable caution in interpreting this correlation as a cause-and-effect relationship.…”

Section: Oncological Necessity Of Complete Mesocolic Excision With Central Vascular Ligationmentioning

confidence: 99%

Is Laparoscopic Complete Mesocolic Excision and Central Vascular Ligation Really Necessary for All Patients With Right-Sided Colon Cancer?

Son

Lee

et al. 2021

Ann Coloproctol

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Colon cancer treatment is on the way to evolution over several decades. The minimally invasive surgery has improved postoperative short-term outcomes. Adjuvant chemotherapy has prolonged the survival of advanced colon cancer patients. Hohenberger proposed the noble concept of complete mesocolic excision (CME) which consists of 3 components: plane surgery, sufficient longitudinal bowel resection, and central vascular ligation (CVL). Mesocolic plane surgery shares the same surgical principle of total mesorectal excision, which is maintaining the intact mesothelial envelope. However, there remain debates about the extent of bowel resection and the level of CVL for maximizing lymph node dissection. There is no solid clinical evidence for the oncological necessity and benefit of extended radical dissection in right hemicolectomy. CME with CVL based on open surgery has been adopted in laparoscopic surgery. So, it is also necessary to look at how the CME could be transformed and successfully implanted in the laparoscopic era. Recent rapid advances in surgical technology and cancer biology are preparing for fundamental changes in cancer surgery. In this study, we reviewed the history, oncological necessity, and compatibility of CME for the right hemicolectomy in the laparoscopic era and outline the new perspectives on the evolution of cancer surgery.

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“…The number of NLNs was obtained by subtracting the number of PLNs from the total number of RLNs. The NLN intervals were as follows: NLN1 (≤7), NLN2 (8)(9)(10)(11)(12)(13), and NLN3 (≥14).…”

Section: Lymph Node Classificationsmentioning

confidence: 99%

“…Several studies have also demonstrated that the number of NLNs is positively correlated with the OS of EC patients 11 . The higher the number of NLNs a patient has, the better the prognosis 12, 13 …”

Section: Introductionmentioning

confidence: 99%

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Ratio between negative and positive lymph nodes is a novel prognostic indicator for patients with esophageal cancer: A Surveillance, Epidemiology and End Results database analysis

et al. 2020

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Background: The aim of this study was to explore whether the ratio between negative and positive lymph nodes (R NP) could predict the overall survival (OS) of esophageal cancer (EC) patients with lymph node metastasis following esophagectomy. Methods: We utilized the Surveillance, Epidemiology and End Results (SEER) database to include the records of 2374 patients with lymph node metastases post-surgery. All patients were randomly assigned into the training cohort (n = 1424) and validation cohort (n = 950). Multivariate Cox regression analyses were performed to identify independent prognostic factors. A novel R NP-based TR NP M staging system was proposed. The prognostic value of N, R NP , TNM and TR NP M staging system was evaluated using the linear trend χ 2 test, likelihood ratio χ 2 test, and Akaike information criterion (AIC) to determine the potential superiorities. We constructed nomograms to predict survival in both cohorts, and the calibration curves confirmed the predictive ability. Results: Univariate analyses showed that N and R NP stage significantly influenced the OS of patients. Multivariate analyses revealed that R NP was an independent prognostic predictor in both the training and validation cohorts. For the stratification analysis in the two cohorts, we found significant differences in the prognosis of patients in different R NP groups on the basis of the different N stages and the number of dissected lymph nodes. In addition, the lower AIC value of R NP stage and TR NP M staging system represented superior predictive accuracy for OS than the N stage and TNM staging system, respectively. Furthermore, the calibration curves for the probability of three-and five-year survival showed good consistency between nomogram predictive abilities and actual observation. Conclusions: We demonstrated that compared to the classical pathological lymph nodal staging system, the R NP stage showed superior predictive accuracy for OS and can serve as a more effective prognostic guidance for lymph node positive EC patients.

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Impact of negative lymph nodes on colon cancer survival and exploring relevant transcriptomics differences through real-world data analyses

Cited by 5 publications

References 27 publications

Negative lymph node count is an independent prognostic factor for female patients with node positive breast cancer

Negative lymph node count is an independent prognostic factor for female patients with node positive breast cancer

Is Laparoscopic Complete Mesocolic Excision and Central Vascular Ligation Really Necessary for All Patients With Right-Sided Colon Cancer?

Ratio between negative and positive lymph nodes is a novel prognostic indicator for patients with esophageal cancer: A Surveillance, Epidemiology and End Results database analysis

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