Impact of Neoadjuvant Chemotherapy on Breast Cancer Biomarkers: A Guide for Further Adjuvant Treatment

Eladawei, Ghada Ezzat

doi:10.11648/j.crj.20190701.12

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…2 It is postulated that there may be alteration in hormone and Her 2 Neu expression status following NACT. There are several studies in the Indian population 3,4 in this regard but those studies used different cut off, criteria for NACT and non-uniform study design. Our study was designed to reevaluate the alteration of HR status and Her-2/ neu status so that patient will be benefited by specific adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

The Predictive and Prognostic behavior of Breast Cancer by NACT in Relation to Tumor Grade, ER/PR and Her- 2/neu Expression- Study in a Tertiary Care Hospital of Eastern India

Das¹,

Ghosh²,

Guha³

2019

IJCMR

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Introduction: Neo-adjuvant chemotherapy (NACT) is considered as initial management of all patients with locally advanced breast cancers and followed by surgery. NACT enables reduction of breast tumor size-thereby prolonging survival and altered the expression of steroid receptor (ER/PR) and Her-2/NEU in the cancer cells. Our aims and objective was to look into the association of patient age, tumor grade, expression status of ER/ PR / Her-2/neu receptor status before and after NACT in Indian women patients. Material and methods: The study was conducted over a period of 4 years. Hormone receptor and Her-2/neu status was determined by IHC over 412 samples. The patients receiving NACT and having both core needle biopsy and surgery (MRM) are considered as NACT group. The other group did not receive NACT but have core needle biopsy and surgery are taken as non NACT group. The discordance was compared between these two groups. Results: Patients of more than 40years of age had predominantly favorable hormone receptor status expression. In the NACT group favorable receptor status was 60.35% and discordance was higher in ER, PR and HER-2/neu in comparison to non-NACT group. Conclusions: Significant alteration of hormone receptors and Her-2/neu expression was found in biopsy of the patients receiving NACT. So reevaluation of the hormonal status and Her 2 neu receptor in residual invasive carcinoma may be considered as it has advantage on chemotherapy after final surgery.

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Section: Introductionmentioning

confidence: 99%

The Predictive and Prognostic behavior of Breast Cancer by NACT in Relation to Tumor Grade, ER/PR and Her- 2/neu Expression- Study in a Tertiary Care Hospital of Eastern India

Das¹,

Ghosh²,

Guha³

2019

IJCMR

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Discordance of estrogen and progesterone receptors after neoadjuvant chemotherapy in locally advanced breast cancer

Gupta

Anto

Singhal

et al. 2022

Journal of Cancer Research and Therapeutics

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Aims and Objective: This study aimed to compare hormone receptor (HR) status before and after neoadjuvant chemotherapy that is discordance in locally advanced breast cancer patients, which are amenable for surgery. The secondary objective was to study the correlation between tumor response and HR expression. Materials and Methods: The duration of the study was from August 2018 to December 2020. A total of 23 patients were selected as per certain inclusion criteria. American Society of Clinical Oncologys methodology was used to analyze estrogen receptor (ER) and progesterone receptor (PR) status of histopathology specimen. For study purposes, patients were classified into four groups after core biopsy of breast lump and after definitive surgery (post-NACT (neoadjuvant chemotherapy)) – Group A (ER+, PR+), Group B (ER+, PR−), Group C (ER−, PR+), and Group D (ER−, PR−). Results: ER discordance was found to be (2/23) 8.69% (P value 0.76). PR discordance was (4/23) 17.39%. PR discordance was found to be higher than ER discordance. Changes in staining patterns in ERs were seen in 14 patients (93.33%). Changes in staining percentage in PRs were seen in eight patients (80%). It was found that both receptor-positive and negative diseases had an equal proportion of stable disease. Conclusion: From the study, it is noted that performing ER PR study twice (before and after chemotherapy) is necessary as discordance is noted and this may impact the further treatment strategy.

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Impact of Neoadjuvant Chemotherapy on Breast Cancer Biomarkers: A Guide for Further Adjuvant Treatment

Cited by 2 publications

References 30 publications

The Predictive and Prognostic behavior of Breast Cancer by NACT in Relation to Tumor Grade, ER/PR and Her- 2/neu Expression- Study in a Tertiary Care Hospital of Eastern India

The Predictive and Prognostic behavior of Breast Cancer by NACT in Relation to Tumor Grade, ER/PR and Her- 2/neu Expression- Study in a Tertiary Care Hospital of Eastern India

Discordance of estrogen and progesterone receptors after neoadjuvant chemotherapy in locally advanced breast cancer

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