Impact of neointimal tissue characterization and heterogeneity of bare-metal stents and drug-eluting stents on the time course after stent implantation evaluated by integrated backscatter intravascular ultrasound

Yoshizane, Takashi; Tanaka, Shinichiro; Abe, Shintaro; Ueno, Takahiro; Goto, Yuichi; Kojima, Tai; Itō, Makoto; Arai, M.; Noda, Toshiyuki; Kawasaki, Masanori

doi:10.1007/s00380-019-01410-4

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…However, current guidelines strongly suggest their use, preferentially OCT, to investigate the mechanisms of stent failure [ 2 , 58 ]; increasing awareness and understanding of NA mechanisms, they might potentially guide appropriate invasive treatments. Table 3 reports the most important studies investigating the usefulness of IVUS and OCT in the NA setting [ 14 , 42 , 47 , 54 , 55 , 56 , 59 , 60 , 61 , 62 , 63 , 64 ]. Figure 2 shows in-stent NA detected by IVUS (panel A) and OCT (panel B).…”

Section: In-stent Restenosis and Neo-atherosclerosis: The Pivotal Rol...mentioning

confidence: 99%

In Stent Neo-Atherosclerosis: Pathophysiology, Clinical Implications, Prevention, and Therapeutic Approaches

Nusca

Viscusi

Piccirillo

et al. 2022

Life

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Despite the dramatic improvements of revascularization therapies occurring in the past decades, a relevant percentage of patients treated with percutaneous coronary intervention (PCI) still develops stent failure due to neo-atherosclerosis (NA). This histopathological phenomenon following stent implantation represents the substrate for late in-stent restenosis (ISR) and late stent thrombosis (ST), with a significant impact on patient’s long-term clinical outcomes. This appears even more remarkable in the setting of drug-eluting stent implantation, where the substantial delay in vascular healing because of the released anti-proliferative agents might increase the occurrence of this complication. Since the underlying pathophysiological mechanisms of NA diverge from native atherosclerosis and early ISR, intra-coronary imaging techniques are crucial for its early detection, providing a proper in vivo assessment of both neo-intimal plaque composition and peri-strut structures. Furthermore, different strategies for NA prevention and treatment have been proposed, including tailored pharmacological therapies as well as specific invasive tools. Considering the increasing population undergoing PCI with drug-eluting stents (DES), this review aims to provide an updated overview of the most recent evidence regarding NA, discussing pathophysiology, contemporary intravascular imaging techniques, and well-established and experimental invasive and pharmacological treatment strategies.

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Section: In-stent Restenosis and Neo-atherosclerosis: The Pivotal Rol...mentioning

confidence: 99%

In Stent Neo-Atherosclerosis: Pathophysiology, Clinical Implications, Prevention, and Therapeutic Approaches

Nusca

Viscusi

Piccirillo

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

Differences in vascular tissue response after stent implantation between biolimus-eluting and everolimus-eluting stents: a sub-study of the NEXT study

Imai,

Kawasaki,

Yoshida

et al. 2024

Heart Vessels

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Impact of neointimal tissue characterization and heterogeneity of bare-metal stents and drug-eluting stents on the time course after stent implantation evaluated by integrated backscatter intravascular ultrasound

Cited by 2 publications

References 18 publications

In Stent Neo-Atherosclerosis: Pathophysiology, Clinical Implications, Prevention, and Therapeutic Approaches

In Stent Neo-Atherosclerosis: Pathophysiology, Clinical Implications, Prevention, and Therapeutic Approaches

Differences in vascular tissue response after stent implantation between biolimus-eluting and everolimus-eluting stents: a sub-study of the NEXT study

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