Impact of nepafenac 0.1% on macular thickness and postoperative visual acuity after cataract surgery in patients at low risk for cystoid macular oedema

Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery

“…Some studies included a group of participants who received other types of cataract surgery, in which case we used only the data from the participants who underwent phacoemulsification. The studies were conducted in 17 different countries: three in Brazil (Ticly 2014; Tzelikis 2015; Zanetti 2012), two in Canada (Almeida 2008; Almeida 2012), four in China (Chen 2015; Li 2011; Wang 2013; Zhang 2008), one in Cuba (Ruiz Rodríguez 2011), one in Egypt (Elsawy 2013), one in France (Adam 2005), two in Germany (Hessemer 1996; Schmitt 1995), two in Greece (Chatziralli 2011; Moschos 2012), one in India (Sahu 2015), one in Iran (Entezari 2016), seven in Japan (Asano 2008; Endo 2010; Kato 1998; Miyake 2007; Miyake 2011; Miyanaga 2009; Shimazaki 1996), one in Mexico (Cervantes-Coste 2009), one in South Korea (Jung 2015), two in Sweden (Laurell 2002; Zaczek 2014), one in Thailand (Trinavarat 2003), two in Turkey (Dal 2014; Yavas 2007), and seven in the United States (Duong 2014; el-Harazi 1998; Holzer 2002; Mathys 2010; Singh 2012; Solomon 2001; Wittpenn 2008). Investigators of nine studies did not report in which country the trial had been conducted (Bucci 2001; Demco 1997; Donnenfeld 2006; Guzey 2000; McColgin 1999; Mulet 2001; Ostrov 1997; Roberts 1995; Voudouri 2002).…”

“…Nineteen studies compared a combination of an NSAID plus a corticosteroid with a corticosteroid only (Adam 2005; Almeida 2008; Cervantes-Coste 2009; Chatziralli 2011; Chen 2015; Dal 2014; Elsawy 2013; Entezari 2016; Li 2011; Mathys 2010; McColgin 1999; Moschos 2012; Ruiz Rodríguez 2011; Shimazaki 1996; Singh 2012; Ticly 2014; Wittpenn 2008; Zaczek 2014; Zhang 2008). Fourteen other studies had three or more arms and had such combinations as an NSAID alone versus a corticosteroid alone versus a combination (Hessemer 1996; Miyanaga 2009; Schmitt 1995); multiple NSAIDs compared with each other and versus a corticosteroid (el-Harazi 1998; Mulet 2001; Zanetti 2012); an NSAID versus a corticosteroid versus a different corticosteroid (Ostrov 1997; Trinavarat 2003); and multiple combinations of an NSAID plus a corticosteroid against each other with a corticosteroid-only arm in addition (Almeida 2012; Donnenfeld 2006; Jung 2015; Sahu 2015; Tzelikis 2015; Yavas 2007).…”

Prospective, Randomized Study Comparing the Effect of 0.1% Nepafenac and 0.4% Ketorolac Tromethamine on Macular Thickness in Cataract Surgery Patients With Low Risk for Cystoid Macular Edema

“…This may or may not be noticeable to the patient. However, there is no strong evidence of any long-term adverse effect of subclinical CME on final visual outcome 2,3 ; hence, the routine use of topical NSAIDs for uncomplicated cataract surgery remains debatable. 2,4Y6 Preventing subclinical CME is desirable and may have a potential benefit for final visual outcomes; therefore topical NSAIDs are prescribed routinely at our hospital.…”

Non steroidal anti-inflammatory drugs in the prevention of cystoid macular edema after uneventful cataract surgery

“…In relation to the effectiveness of the use of steroids and NSAIDs, in a prospective cohort, Mathys and Cohen2 evaluated macular thickness and best-corrected visual acuity after cataract surgery in a group that received only standard treatment with moxifloxacin and prednisolone acetate and in a study group to which nepafenac 0.1% was added. It must be emphasized that both the control and study groups had received three nepafenac drops immediately before surgery.…”