Impact of night shifts on laparoscopic skills and cognitive function among gynecologists

Veddeng, Anne; Husby, Thomas; Engelsen, Ingeborg B.; Kent, Andrew

doi:10.1111/aogs.12496

Cited by 18 publications

(17 citation statements)

References 25 publications

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“…Millions of people worldwide work at times that overlap with the normal time for sleep, resulting in significant cognitive impairment and somatic symptoms (Rajaratnam and Arendt, 2001 ). In humans, night shift work in both real-life and laboratory simulations, is known to induce circadian rhythm disturbance which has been linked to deficits in cognitive functions (Folkard, 2008 ; Veddeng et al, 2014 ; Maltese et al, 2016 ; Pilcher et al, 2016 ). Night workers often report impaired alertness and performance on duty, and the risk of errors and accidents is increased at night (Folkard and Tucker, 2003 ; Åkerstedt et al, 2010 ; Øyane et al, 2013 ; Kazemi et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

No Escaping the Rat Race: Simulated Night Shift Work Alters the Time-of-Day Variation in BMAL1 Translational Activity in the Prefrontal Cortex

Marti

Patil

Mrdalj

et al. 2017

Front. Neural Circuits

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Millions of people worldwide work during the night, resulting in disturbed circadian rhythms and sleep loss. This may cause deficits in cognitive functions, impaired alertness and increased risk of errors and accidents. Disturbed circadian rhythmicity resulting from night shift work could impair brain function and cognition through disrupted synthesis of proteins involved in synaptic plasticity and neuronal function. Recently, the circadian transcription factor brain-and-muscle arnt-like protein 1 (BMAL1) has been identified as a promoter of mRNA translation initiation, the most highly regulated step in protein synthesis, through binding to the mRNA “cap”. In this study we investigated the effects of simulated shift work on protein synthesis markers. Male rats (n = 40) were exposed to forced activity, either in their rest phase (simulated night shift work) or in their active phase (simulated day shift work) for 3 days. Following the third work shift, experimental animals and time-matched undisturbed controls were euthanized (rest work at ZT12; active work at ZT0). Tissue lysates from two brain regions (prefrontal cortex, PFC and hippocampus) implicated in cognition and sleep loss, were analyzed with m7GTP (cap) pull-down to examine time-of-day variation and effects of simulated shift work on cap-bound protein translation. The results show time-of-day variation of protein synthesis markers in PFC, with increased protein synthesis at ZT12. In the hippocampus there was little difference between ZT0 and ZT12. Active phase work did not induce statistically significant changes in protein synthesis markers at ZT0 compared to time-matched undisturbed controls. Rest work, however, resulted in distinct brain-region specific changes of protein synthesis markers compared to time-matched controls at ZT12. While no changes were observed in the hippocampus, phosphorylation of cap-bound BMAL1 and its regulator S6 kinase beta-1 (S6K1) was significantly reduced in the PFC, together with significant reduction in the synaptic plasticity associated protein activity-regulatedcytoskeleton-associated protein (Arc). Our results indicate considerable time-of-day and brain-region specific variation in cap-dependent translation initiation. We concludethat simulated night shift work in rats disrupts the pathways regulating the circadian component of the translation of mRNA in the PFC, and that this may partly explain impaired waking function during night shift work.

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Section: Introductionmentioning

confidence: 99%

No Escaping the Rat Race: Simulated Night Shift Work Alters the Time-of-Day Variation in BMAL1 Translational Activity in the Prefrontal Cortex

Marti

Patil

Mrdalj

et al. 2017

Front. Neural Circuits

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“…Current evidence emerging from the literature does not provide a compelling ground to draw consistent conclusions about the effects of SD on surgical dexterity. A number of studies found no significant variations following either acute SD or sleep restriction (59, 61, 62, 64–66, 68, 116, 120), while others found a worsening of quantity and quality performance (45, 48–52) or even improvement in SD condition (63, 121). More specifically, a technical limitation in a systematic overview concerns the array of heterogeneous metrics of performance used to evaluate dexterity, hence preventing a robust statistical analysis or meta-analysis.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

“…Veddeng et al focused their attention on gynecologist interns (64). Twenty-eight gynecologists were enrolled in the study; three expert surgeons were used as reference for the laparoscopic task.…”

Section: Surgeons Sleep Deprivation and Its Effects On Dexteritymentioning

confidence: 99%

Effects of Sleep Deprivation on Surgeons Dexterity

et al. 2019

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Sleep deprivation is an ordinary aspect in the global society and its prevalence is increasing. Chronic and acute sleep deprivation have been linked to diabetes and heart diseases as well as depression and enhanced impulsive behaviors. Surgeons are often exposed to long hour on call and few hours of sleep in the previous days. Nevertheless, few studies have focused their attention on the effects of sleep deprivation on surgeons and more specifically on the effects of sleep deprivation on surgical dexterity, often relying on virtual surgical simulators. A better understanding of the consequences of sleep loss on the key surgical skill of dexterity can shed light on the possible risks associated to a sleepy surgeon. In this paper, the authors aim to provide a comprehensive review of the relationship between sleep deprivation and surgical dexterity.

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“…Much of the research on duty hours focuses on questions related to safety, 7 sleep, 8 and the impact on training. 9 While these are important issues, there is a gap in the literature with respect to studies that investigate the cultural values and priorities of various invested parties (eg, educational institutions, hospital settings, individual learners, and faculty) that are driving the conversations about topics such as duty hours.…”

Section: About Ethnographymentioning

confidence: 99%

Understanding the Culture of Graduate Medical Education: The Benefits of Ethnographic Research

MacLeod

2016

Journal of Graduate Medical Education

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Impact of night shifts on laparoscopic skills and cognitive function among gynecologists

Cited by 18 publications

References 25 publications

No Escaping the Rat Race: Simulated Night Shift Work Alters the Time-of-Day Variation in BMAL1 Translational Activity in the Prefrontal Cortex

No Escaping the Rat Race: Simulated Night Shift Work Alters the Time-of-Day Variation in BMAL1 Translational Activity in the Prefrontal Cortex

Effects of Sleep Deprivation on Surgeons Dexterity

Understanding the Culture of Graduate Medical Education: The Benefits of Ethnographic Research

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