Impact of non‐alcoholic fatty liver disease on chronic hepatitis B

Bondini, Silvia; Kallman, Jillian; Wheeler, Angela; Prakash, Shivaani; Gramlich, Terry L.; Jondle, Daniel; Younossi, Zobair M.

doi:10.1111/j.1478-3231.2007.01482.x

Cited by 107 publications

(131 citation statements)

References 21 publications

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“…However, a negative correlation between NAFLD and serum HBV DNA levels has also been reported in a meta-analysis (7). When the literature regarding the relation between NAFLD and chronic HBV infection was reviewed, the result seems to be inconclusive (3)(4)(5)(6)(7)(8)(10)(11)(12)(13)(14)(15)(16)(17)(18). We think that the cause of the results that were obtained in those studies may relate to the lack of subgroup analysis.…”

Section: Introductionmentioning

confidence: 92%

“…Despite studies that claim an increase in NAFLD in the presence of active viral replication in patients with chronic HBV infection, there are studies that report suppression of viral replication in NAFLD (9,10). Many epidemiological studies have reported no difference regarding HBV replication between patients with NAFLD and those without NAFLD (3)(4)(5)(6)8,(10)(11)(12)(13). However, a negative correlation between NAFLD and serum HBV DNA levels has also been reported in a meta-analysis (7).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir

Ceylan

Arslan²,

Batırel³

et al. 2016

Turk J Gastroenterol

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir

Ceylan

Arslan²,

Batırel³

et al. 2016

Turk J Gastroenterol

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“…On the other hand, most of the data show that a steatosis prevalence in patients with CHB is similar to that of the general population (8,9,10,17). In these studies the presence of steatosis correlates with BMI and metabolic parameters as waist circumference, high blood pressure and dyslipidemia, but not with viral genotype or viral load, and fibrosis (4,8).…”

Section: Discussionmentioning

confidence: 98%

Metabolic Face of Chronic Hepatitis B and C in Bulgaria

Antonov¹,

Jelev²,

Ivanova³

et al. 2011

JofIMAB

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SUMMARYIt is well known that NAFLD, as well as diabetes mellitus (DM), correlated with the progression of liver fibrosis in chronic hepatitis C (CHC). The impact of NAFLD overlap in chronic hepatitis B (CHB) is not well established.Aim. In this study we compared the prevalence of NAFLD and related metabolic parameters in CHC and CHB, and their relationship with disease activity and fibrosis.Methods. The parameters of metabolic syndrome (MetS), glucose, insulin, HOMA-IR and histological features of steatosis / steatohepatitis were investigated in total of 700 patients with chronic viral hepatitis -CHB (n=334) and genotype 1 CHC (n=366). Glucose and insulin were also assessed during OGTT (60 and 120 min.) in 100 cases with CHB and 100 -with CHC.Results. Nonalcoholic metabolic related steatosis was more frequent (62% v/s 48%) and severe in CHC compared to CHB (p<0.01). MetS (51% v/s 33%), and DM OGTT (30% v/ s 20%) were found also in higher frequency in CHC than in cases with CHB (ð<0.001). In the both type hepatitis insulin resistance was associated with disease activity. In CHC, but not in CHB, a positive correlation between the degree of steatosis and the activity score was found (r = 0.322, p<0.05). In 70% of the cases with CHB and severe steatosis (>66%) HBV DNA was negative or <10 000 copies/ml. The advanced liver fibrosis (F3-F4) was associated with moderate or severe steatosis (CHC), as well as with the glucose levels, markers of insulin resistance, and presence of DM (p<0.001), but not with the other components of metabolic syndrome.In conclusion, nonalcoholic metabolic related steatosis, diabetes mellitus and insulin resistance are associated with the both viral hepatitis, but the prevalence is higher in chronic hepatitis C. The degree of steatosis correlates with the activity grade and stage of fibrosis only in patients with chronic hepatitis C. Insulin resistance and diabetes mellitus are associated with more advanced liver fibrosis in the both viral hepatitis.

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“…[16], достоверных различий в достижении УВО на фоне ожирения не выяв-лено. Однако пациенты этой категории заслуживают бо-лее пристального внимания, так как на фоне присоедине-ния ИР в условиях окислительного стресса включаются реакции фиброгенеза в печени, усугубляется ИР [17], что приводит к риску снижения ответа на лечение. ИР и/или СД 2-го типа являются значительными и независимыми факторами развития фиброза печени у пациентов различ-ных категорий, а у пациентов с ХВГС приводят к досто-верно более быстрому, чем у пациентами без ИР или СД, прогрессированию фиброза [18][19][20][21][22].…”

Section: Discussionunclassified

Use of a regional registry of chronic hepatitis patients to optimize antiviral therapy

et al. 2015

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РезюмеЦель исследования. Определить общую характеристику больных хроническим вирусным гепатитом С (ХВГС) по данным регистра пациентов с вирусными гепатитами (ВГ) в Ставропольском крае, оценить возможные предикторы неэффектив-ности противовирусной терапии (ПВТ) для оптимизации лечения. Материалы и методы. Проведен ретроспективный анализ результатов обследования и лечения пациентов с ХВГС по данным регистра пациентов с ВГ в Ставропольском крае за 2008-2013 гг. Результаты. В регистре пациентов с хроническими гепатитами состоят на учете 1811 пациентов с ХВГС, из них 64% боль-ные с 1-м генотипом вируса. По данным регистра, цирроз печени выявлен у 244 (13,5%), фиброз F2-3 METAVIR -у 724 (39,97%), у остальных 843 больных -фиброз F0-1METAVIR. У 615 (34%) пациентов выявлены нарушения углеводного и жирового обмена (ожирение, инсулинорезистентность -ИР, сахарный диабет -СД), у каждого 3-го выявляли патологию желудочно-кишечного тракта, и только у 24% пациентов отсутствовала сопутствующая патология. Проанализированы результаты ПВТ у 493 больных ХГС 1-го генотипа. При анализе предикторов неэффективности ПВТ наиболее значимыми оказались НОМА-ИР >2, наличие ИР (НОМА-ИР >2,77) и СД 2-го типа, а также возраст пациентов старше 45 лет, мужской пол, вирусная нагрузка ≥6 log10 ME/мл и фиброз печени ≥F3 METAVIR. Заключение. Анализ заболеваемости ВГ в крае, создание регистра больных хроническими ВГ, наличия в нем граф, отра-жающих ИР, индекс массы тела, динамику вирусологического ответа в процессе лечения, позволили уточнить истинную потребность нуждающихся в ПВТ, совершенствовать работу по диспансеризации и оптимизации терапии у пациентов этой категории в районах края. Results. The chronic hepatitis registry includes 1811 patients with CVHC; out of them there are 64% who have its virus genotype 1. According to the registry, there is cirrhosis in 244 (13.5%) patients, fibrosis , and fibrosis (METAVIR F0-F1) in the remaining 843. Carbohydrate and fat metabolic disturbances (obesity, insulin resistance (IR), and diabetes mellitus (DM)) have been found in 615 (34%) patients; every three patients have gastrointestinal diseases and comorbidity is absent in 24% of the patients. The results of AVT were analyzed in 493 patients with CHC virus genotype 1. The analysis showed the most important predictors for the inefficiency of AVT; these included HOMA-IR >2, the presence of IR (HOMA-IR >2.77), and type 2 DM, as well as patient age over 45 years, male sex, a viral load of ≥6 log10 IU/ml, and liver fibrosis (METAVIR ≥F3). Conclusion. The analysis of VH morbidity in the Stavropol Territory, the making of a registry of patients with chronic VH, its columns of IR, body mass index, virologic response changes during therapy could clarify the actual need in AVT and improve activities in the prophylactic medical examination and treatment optimization in this patient group in the areas of this region. Keywords: general characteristics of patients with chronic hepatitis C; registry; predictors for inefficiency of therapy.АлАТ -аланинаминотрансфераза БВО...

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Impact of non‐alcoholic fatty liver disease on chronic hepatitis B

Abstract: The components of MS (obesity, hypertension, and dyslipidaemia) are associated with the presence of NASH in patients with CH-B. The presence of hepatic fibrosis seems to be associated with known host and viral factors as well as the presence of abdominal obesity.

Cited by 107 publications

References 21 publications

Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir

Impact of fatty liver on hepatitis B virus replication and virologic response to tenofovir and entecavir

Metabolic Face of Chronic Hepatitis B and C in Bulgaria

Use of a regional registry of chronic hepatitis patients to optimize antiviral therapy

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