Impact of non‐CNS childhood cancer on resting‐state connectivity and its association with cognition

Spitzhüttl, Janine Sophie; Kronbichler, Martin; Kronbichler, Lisa; Benzing, Valentin; Siegwart, Valerie; Pastore‐Wapp, Manuela; Kiefer, Claus; Slavova, Nedelina; Grotzer, Michael A.; Roebers, Claudia M.; Steinlin, Maja; Leibundgut, Kurt; Everts, Regula

doi:10.1002/brb3.1931

Cited by 6 publications

(2 citation statements)

References 66 publications

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“…Our findings suggest that CNS involvement is a key risk factor that predicts cognitive outcomes. However, our own research shows that cerebral alterations on the level of resting-state functional networks are altered even in CC survivors without CNS involvement (Spitzhüttl et al, 2020). Past studies have found that age at diagnosis is linked to cognitive functioning (Mulhern & Palmer, 2003;Mulhern et al, 2004;Sands et al, 2001).…”

Section: Clinical Risk Factorsmentioning

confidence: 66%

Cognition, psychosocial functioning, and health-related quality of life among childhood cancer survivors

Siegwart

Benzing

Spitzhuettl

et al. 2020

Neuropsychological Rehabilitation

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Long-term sequelae of cancer and its treatment render childhood cancer (CC) survivors vulnerable to cognitive and behavioural difficulties and likely affect their quality of life (QoL). Our aim was to compare levels of cognition, psychosocial functioning, and health-related QoL of CC survivors to healthy controls and examine the associations between these three domains. Seventy-eight CC survivors (age range = 7-16 years, ≥ one year since cancer treatment) and 56 healthy controls were included. Cognition (i.e., fluid intelligence, executive functions, memory, processing speed, and selective attention), psychosocial functioning, and health-related QoL were assessed using standardized tests and questionnaires. The cognitive performance, parent-reported psychosocial behaviour, and health-related QoL of the CC survivors were within the normative range. However, working memory was significantly poorer in survivors than controls, and visuospatial working memory below the normative range was more commonly observed among survivors than among controls. Processing speed significantly predicted survivors' performance in executive functions. Among survivors, greater peer problems were significantly associated with poorer cognitive functions and health-related QoL. Despite the evidence for good intellectual functioning, which might point towards adequate reserves, in some survivors, domain-specific difficulties may emerge years after cancer relating to psychosocial development and QoL.

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Section: Clinical Risk Factorsmentioning

confidence: 66%

Cognition, psychosocial functioning, and health-related quality of life among childhood cancer survivors

Siegwart

Benzing

Spitzhuettl

et al. 2020

Neuropsychological Rehabilitation

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“…ACE‐III includes tests of attention, orientation, memory, fluency, language and visuospatial abilities, with a maximum score of 100. Although ACE‐III is employed commonly as a Dementia screening tool, it was selected because fronto‐temporal areas play a role in mediating execute functions 11 and compromise in executive functions have been reported in sarcoma patients undergoing chemotherapy 12 . Nevertheless this assessment has not been utilized in younger patients, it should be noted that we have used raw scores rather than normative scores for comparison of neuropsychological assessment among groups.…”

Section: Methodsmentioning

confidence: 99%

Patient‐reported cognitive impairments and objective neuropsychological deficits in young sarcoma patients undergoing chemotherapy and its comparison to healthy controls: A tertiary health care study from India

Vayyat,

Revand,

Rastogi

et al. 2023

Intl Journal of Cancer

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The study aims to investigate the patient‐reported cognitive deficits and objective neuropsychological functions in younger adult (YA) sarcoma patients (16–40 years of age). Ninety patients and 30 age‐matched healthy controls from a single tertiary healthcare hospital, were recruited into four groups: Pre‐chemotherapy (Pre Cx), During chemotherapy (During Cx), Post‐chemotherapy (Post Cx) and Controls. Neurocognitive functions were assessed subjectively using FACT‐Cog v3 questionnaire; objectively using ACE‐III and neuropsychological tests (NPT). FACT‐Cog scores of During Cx (P = .041) and Post Cx (P = .008) groups were significantly lower than Pre Cx group. ACE‐III scores of During Cx (P = .048) and Post Cx (P = .043) groups were lower as compared to Pre Cx group. In addition, reaction times and accuracies of the NPT (Flanker's, Sternberg's and Emotional Stroop tests) were worse (P < .05) in During Cx and Post Cx groups as compared to either Pre Cx or control groups. In the Post Cx group, the dose of chemotherapy showed significant negative correlation with the Sternberg reaction time (P = .040) as well as the scores of language (P = .047), and attention (P = .044) domains of ACE‐III. Observations demonstrate that cancer/chemotherapy‐related neurocognitive deficits fail to improve even after cessation of treatment, and high dosage of chemotherapy used, could be an underlying factor. This emphasizes the need for developing ‘model of care’ in these patients for monitoring the side effects, and possible titration in the therapeutic regimen for sarcoma in YA.

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Cognitive deficits and altered functional brain network organization in pediatric brain tumor patients

Seitzman,

Anandarajah,

Dworetsky

et al. 2023

Brain Imaging and Behavior

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Impact of non‐CNS childhood cancer on resting‐state connectivity and its association with cognition

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 66 publications

Cognition, psychosocial functioning, and health-related quality of life among childhood cancer survivors

Cognition, psychosocial functioning, and health-related quality of life among childhood cancer survivors

Patient‐reported cognitive impairments and objective neuropsychological deficits in young sarcoma patients undergoing chemotherapy and its comparison to healthy controls: A tertiary health care study from India

Cognitive deficits and altered functional brain network organization in pediatric brain tumor patients

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