Pulmonary impairment and decreased functional capacity are significant concerns following cardiovascular surgery, leading to extended hospital stays and mortality. Non-invasive ventilation (NIV) can provide significant prophylactic and therapeutic benefits in pre-operative and postoperative respiratory failure following coronary artery bypass grafting (CABG) surgery. Despite scant data, non-invasive ventilation outcomes are promising in phase I cardiac rehabilitation. There exists evidence that validates the utilization of non-invasive ventilation in the acute phase of cardiac rehabilitation and its application in patients following CABG; this context continues to be a subject of controversy within the existing body of literature. The purpose of this chapter is to demonstrate the efficacy of non-invasive ventilation as a prophylactic and therapeutic intervention for patients undergoing coronary artery bypass grafting (CABG) surgery, with the obvious aim of mitigating the occurrence of postoperative pulmonary dysfunction and decreased functional capacity.