Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson's disease

Santos‐García, Diego; Fuente‐Fernández, Raúl de la

doi:10.1016/j.jns.2013.07.005

Cited by 140 publications

(120 citation statements)

References 32 publications

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“…For example, in a recent study, PD-related motor symptoms more strongly affected QOL than non-motor symptoms when using PDQ-39, whereas non-motor symptoms had a greater impact over perceived QOL, as evaluated by the PQ-10 [20]. In our study, using the PDQ-8, NMSS scores were more strongly associated with a worse QOL than UPDRS part III scores.…”

Section: Discussionsupporting

confidence: 44%

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

et al. 2015

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Parkinson's disease (PD) is a multisystem disorder, and besides the classical motor symptoms it is now known that patients also suffer from a variety of non-motor symptoms that adversely affect quality of life (QOL). Since data on Hispanic populations on this issue are scarce, our aim was to study the association of non-motor symptoms and QOL in patients with PD. This study is a cross-sectional observational study involving patients with PD using the following instruments: Quality of Life Questionnaire (PDQ-8), Unified Parkinson's Disease Rating Scale part III (UPDRS part III), and Non-Motor Symptom Scale (NMSS). We included 52 patients, with a median age of 64 years. Sleep/fatigue and mood/cognitive domains were the most common non-motor symptoms. Only sleep/fatigue, mood/cognition and gastrointestinal domains were associated with worse PDQ-8 scores. After adjusting for confounding variables, NMSS scores were significantly associated with a high PDQ-8 score. Higher NMSS scores were associated with and predicted higher PDQ-8 scores. The focus of management in PD should shift to a comprehensive strategy that incorporates care of non-motor symptoms and improves QOL.

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Section: Discussionsupporting

confidence: 44%

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

et al. 2015

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“…Recently the non-motor symptoms (NMS) of Parkinson's disease (PD) have been increasingly recognized as major burden of quality of life 1,2 . Among the NMS, sleep-related problems are one of the most important and troublesome.…”

Section: Introductionmentioning

confidence: 99%

Independent validation of Parkinson’s disease Sleep Scale 2nd version (PDSS-2)

Kovács

Horváth

Aschermann

et al. 2015

Sleep Biol. Rhythms

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Sleep problems are one of the most common non-motor symptoms of Parkinson's disease (PD). The Parkinson's disease Sleep Scale 2 nd version (PDSS-2) was published in 2011 showing satisfactory clinimetric results. We performed an independent testing of the scale adding further information on its clinimetric properties.In this nationwide study 537 PD patients were enrolled. Besides PDSS-2, we assessed Patient's Global Impression-Severity (PGI) scale on sleep disturbances, Non-motor Symptoms Scale and MDS-UPDRS.Following the Classical Theory of Tests we performed descriptive data analysis, factor analysis, reliability, validity and precision measurements. Subsequently, we evaluated cut-off value for detecting clinically meaningful sleep problems based on receiver operating characteristics analysis.Based on the PGI scale, 161 patients (30.0%) did not reported any sleep problems. Factor analysis revealed almost the same factor structure described by the original PDSS-2 validation study. Cronbach's alpha was 0.863 and all item had good item-total correlation. PDSS-2 demonstrated high convergent validity with Non-Motor Symptoms Scale and Clinical Global Impression-Severity and non-motor part of MDS-UPDRS, and divergent validity with age, gender, education-level, disease-duration and Hoehn-Yahr Stages.Presence of sleep problems was identified by scores >10.5 points on PDSS-2 (sensitivity: 85.3%, specificity: 60.8%, diagnostic accuracy: 78.1%); whereas scores >19.5 points indicated marked sleep-related problems (specificity: 68.5%, sensitivity: 78.0%, diagnostic accuracy: 74.3%).Independent and cross-cultural validation of patient reported outcomes is essential to confirm or reject the findings obtained by the developers of the scale. Our results demonstrate that fundamental clinimetric properties of the PDSS-2 are satisfactory.

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“…Recently the non-motor symptoms (NMS) of Parkinson's disease (PD) have been increasingly recognized as a major burden of quality of life [1,2]. Among the NMS, sleep-related problems are the most important and troublesome.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Subthalamic Stimulation can Improve Sleep Quality in Parkinson’s Disease

Deli

Aschermann

Ács

et al. 2015

Journal of Parkinson’s Disease

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Abstract.Background: Sleep problems are among the most common non-motor symptoms of Parkinson's disease (PD). The PD Sleep Scale 2nd version (PDSS-2) improved the original PDSS by adding more items on different aspects of sleep problems, making it a more robust tool to evaluate the severity of sleep disturbances. However, previous studies on deep brain stimulation (DBS) have not used the PDSS-2. Objective: To determine if the PDSS-2 could detect improvement reliably in sleep problems after bilateral subthalamic nucleus DBS for PD. Methods: In this prospective study, 25 consecutive patients undergoing DBS implantation were enrolled. Patients were examined twice: 1 week prior to the DBS implantation (baseline) and 12 months postoperatively. Severity of PD symptoms were assessed by the Movement Disorders Society Unified PD Rating Scale (MDS-UPDRS) and the Non-Motor Symptoms Scale (NMSS). Presence and severity of sleep disturbances were specifically measured by PDSS-2. Results: Total score of MDS-UPDRS improved from 81 (median, interquartile-range: 63-103) to 55 points (median, IQR: 46-75, p < 0.001). Health-related quality of life, measured by PDQ-39, also improved from 29 (IQR: 18-40) to 15 (IQR: 9-28) points (p = 0.002). Most domains of NMSS also improved. At baseline 13 patients reported sleep problems, but 1 year after DBS implantation only 3 did (p = 0.012). Although only 6 out of 15 items showed a significant decrease after DBS implantation, the total score of PDSS-2 decreased from 24 (IQR: 17-32) to 10 (IQR: 7-18) points (P < 0.001). Conclusions: Based on our results, PDSS-2 can detect improvements in sleep quality reliably after DBS implantation.

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Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson's disease

Cited by 140 publications

References 32 publications

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

Independent validation of Parkinson’s disease Sleep Scale 2nd version (PDSS-2)

Bilateral Subthalamic Stimulation can Improve Sleep Quality in Parkinson’s Disease

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