Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials

Lippi, Lorenzo; Uberti, Francesca; Folli, Arianna; Turco, Alessio; Curci, Claudio; D’Abrosca, Francesco; Sire, Alessandro de; Invernizzi, Marco

doi:10.1007/s40520-022-02203-y

Cited by 30 publications

(29 citation statements)

References 72 publications

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“…A pool systematic review of six studies showed that cognitive impairment was significantly associated with sarcopenia (OR, 1.62; 95% CI, 1.05-2.51) [18]. Sarcopenia has a poor prognosis [31], future studies should be emphasizing the role of tailored risk factors screening, including malnutrition and dysphagia [32,33], in older adults in order to perform a personalized approach including physical exercise and nutritional intervention [34].…”

Section: Sarcopenia and Severe Sarcopenia Risk Factorsmentioning

confidence: 99%

The prevalence and risk factors of sarcopenia among Thai community-dwelling older adults as defined by the Asian Working Group for Sarcopenia (AWGS-2019) criteria: a cross-sectional study

et al. 2022

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Background This study aimed to determine the prevalence and risk factors for sarcopenia and severe sarcopenia among urban community-dwelling adults in Thailand, using the Asian Working Group for Sarcopenia (AWGS-2019) criteria. Methods This cross-sectional study comprising 892 older adults aged > 60 years analyzed data from a cohort study (Bangkok Falls study; 2019–2021). The appendicular skeletal muscle mass was evaluated using the Bioelectrical Impedance Analysis (BIA) method. Physical performance and muscle strength were evaluated using the five-time sit-to-stand and handgrip strength tests, respectively. Logistic regression was used to determine the factors associated with sarcopenia. Results The prevalence rates of sarcopenia and severe sarcopenia were 22.2% and 9.4%, respectively. Age ≥ 70 years (adjusted odds ratio (aOR), 2.40; 95% confidence interval (CI), 1.67–3.45), body mass index (BMI) of < 18.5 kg/m2 (aOR, 8.79; 95% CI, 4.44–17.39), Mini Nutritional Assessment (MNA) score of < 24 (aOR, 1.75; 95% CI, 1.24–2.48), and a six-item cognitive screening test score of ≥ 8 (aOR, 1.52; 95% CI, 1.08–12.15) were associated with sarcopenia. Likewise, age ≥ 70 years, BMI < 18.5 kg/m2, and an MNA score of < 24 predicted severe sarcopenia. Conclusion One-third of the urban community-dwelling older Thai adults had sarcopenia or severe sarcopenia. The age ≥ 70 years, low BMI, and inadequate nutrition increased the risk of both sarcopenia and severe sarcopenia while impaired cognitive functions predicted only sarcopenia in this population.

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Section: Sarcopenia and Severe Sarcopenia Risk Factorsmentioning

confidence: 99%

The prevalence and risk factors of sarcopenia among Thai community-dwelling older adults as defined by the Asian Working Group for Sarcopenia (AWGS-2019) criteria: a cross-sectional study

et al. 2022

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“…In line with these considerations, sarcopenia is highly prevalent in COPD patients and should be targeted by a personalized nutritional approach including adequate dietary protein intake. In addition, a recent report underlined that dietary supplements might have a positive role in age-related conditions interacting with oxidative stress and mitochondrial dysfunction frequently characterizing COPD patients [ 120 ]. However, a recent systematic review underlined that there is insufficient evidence to support the integration of nutritional interventions with PR in COPD patients due to the heterogeneity of COPD clinical presentation and dietary supplements, outcome measures and PR programs [ 121 ].…”

Section: Nutraceuticals and Dietary Supplementsmentioning

confidence: 99%

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Sire

Lippi

Aprile

et al. 2022

JPM

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Osteoporosis is a highly prevalent condition affecting a growing number of patients affected by chronic obstructive pulmonary disease (COPD), with crucial implications for risk of fragility fractures, hospitalization, and mortality. Several risk factors have been identified to have a role in osteoporosis development in COPD patients, including corticosteroid therapy, systemic inflammation, smoke, physical activity levels, malnutrition, and sarcopenia. In this scenario, a personalized multitarget intervention focusing on the pathological mechanisms underpinning osteoporosis is mandatory to improve bone health in these frail patients. Specifically, physical exercise, nutritional approach, dietary supplements, and smoke cessation are the cornerstone of the lifestyle approach to osteoporosis in COPD patients, improving not only bone health but also physical performance and balance. On the other hand, pharmacological treatment should be considered for both the prevention and treatment of osteoporosis in patients at higher risk of fragility fractures. Despite these considerations, several barriers still affect the integration of a personalized approach to managing osteoporosis in COPD patients. However, digital innovation solutions and telemedicine might have a role in optimizing sustainable networking between hospital assistance and community settings to improve bone health and reduce sanitary costs of the long-term management of COPD patients with osteoporosis.

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Section: Agingmentioning

confidence: 99%

“…The five papers on geriatrics and nutraceuticals [9][10][11][12][13]are disparate in their scope and evaluations, making it difficult to draw any meaningful conclusions. Four are SRs [9,10,12,14], and one a narrative review [13]. Martinez-Amat et al, in 2018 published an SR of RCTs that investigated effects of exercise interventions with or without nutritional supplementation for older adults with sarcopenic obesity.…”

Section: Agingmentioning

confidence: 99%

“…Of the initial 8489 records they screened, rather disappointingly, only six were included in the final review. However, the six papers together assessed over 200 individuals and the authors conclude that the RCTs in general support positive impacts from various dietary supplements (sodium nitrite, N-3-polyunsatuarted fatty acids, nicotinamide riboside, hydrogen-rich water, urolithin A, and whey protein) on mitochondrial function and morphology [12]. Unfortunately, we were unable to access the full-text of the Mocchegiani et al, manuscript [9] whose SR focussed on micronutrientgene interactions in ageing and inflammation.…”

Section: Agingmentioning

confidence: 99%

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Nutraceuticals in Personalized and Precision Medicine – a preliminary scoping review indicates efficacy for disease treatment, general wellbeing, and defense against Covid-19

Zahir¹

2022

Preprint

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Nutraceuticals have taken the spotlight during the past two decades as evidenced by the exponential publications on them. Long a part of routine in Traditional Medicine Systems, the rise of their mainstream use globally raises both safety concerns and need for better understanding of efficacious dosing. We attempt to answer these questions in this preliminary scoping review by an analysis of current literature on nutraceutical use as a personalized or prescription medicine. Using Covidence, Rayyan, and manual searches of PubMed, 598 unique publications were selected. 32 are systematic reviews, of which we overview the scope. We also overview 30 papers that address adverse drug reactions. To obtain an unbiased landscape of the 598 papers, we analyzed keywords using multiple methods. Expectedly, the most frequent keywords were probiotics and vitamins. Unexpectedly and remarkably, among the highest keyword yield was ‘COVID’. Further exploring this aspect, we review 15 pertinent papers, that not only provide robust evidence for nutraceutical benefits as part of SARS-CoV-2 treatment, but also amplify the notion that nutraceuticals are protective. Overall, the strident note is that further robust targeted research is needed in order to reap the full benefits of nutraceuticals in a safe and efficacious manner.

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Impact of nutraceuticals and dietary supplements on mitochondria modifications in healthy aging: a systematic review of randomized controlled trials

Cited by 30 publications

References 72 publications

The prevalence and risk factors of sarcopenia among Thai community-dwelling older adults as defined by the Asian Working Group for Sarcopenia (AWGS-2019) criteria: a cross-sectional study

The prevalence and risk factors of sarcopenia among Thai community-dwelling older adults as defined by the Asian Working Group for Sarcopenia (AWGS-2019) criteria: a cross-sectional study

Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Nutraceuticals in Personalized and Precision Medicine – a preliminary scoping review indicates efficacy for disease treatment, general wellbeing, and defense against Covid-19

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