Impact of Obesity and Weight Loss on Cardiac Performance and Morphology in Adults

Alpert, Martin A.; Omran, Jad; Mehra, Ankit; Ardhanari, Sivakumar

doi:10.1016/j.pcad.2013.09.003

Cited by 219 publications

(223 citation statements)

References 75 publications

Supporting

Mentioning

204

Contrasting

Unclassified

Order By: Relevance

“…The benefits of weight loss on the heart are well known. They include reductions in cardiac work, LV mass, LV thickness, and diastolic dimensions 63. Obese patients with LV systolic dysfunction have improvement in LV systolic function after substantial weight loss.…”

Section: Weight Loss In Heart Failurementioning

confidence: 99%

Obesity paradox in heart failure: a heavy matter

et al. 2016

View full text Add to dashboard Cite

Obesity and heart failure are two of the leading causes of morbidity and mortality in the world. The relationship between obesity and cardiovascular diseases is complex and not fully understood. While the risk of developing heart failure has been shown to be higher in patients who are obese, there is a survival advantage for obese and overweight patients compared with normal weight or low weight patients. This phenomenon was first described by Horwich et al. and was subsequently confirmed in other large trials. The advantage exists irrespective of the type, aetiology, or stage of heart failure. Patients with morbid obesity (body mass index >40 kg/m2), however, do not have the same survival advantage of their obese counterparts. There are several alternative indices of obesity available that may be more accurate than body mass index. The role of weight loss in patients with heart failure is unclear; thus, providing sound clinical advice to patients remains difficult. Future prospective trials designed to evaluate the link between obesity and heart failure will help us understand more fully this complex relationship.

show abstract

Section: Weight Loss In Heart Failurementioning

confidence: 99%

Obesity paradox in heart failure: a heavy matter

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Increased filling pressure and volume induce left ventricular dilatation; myocardial mass then increases and gives rise to eccentric left ventricular hypertrophy. Ongoing hemodynamic stress causes left ventricular diastolic and systolic dysfunction (1,3,7,14,15). Left ventricular filling is abnormal, peak atrial velocity is higher, and late diastolic flow rate is longer in the obese subjects.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Left Ventricular Mass with BMI and Insulin Resistance in Normotensive Obese Women

Altinok¹,

Erdenen²,

Karabağ³

et al. 2016

Istanbul Med J

View full text Add to dashboard Cite

The relationship between excess body weight and cardiovascular disease has been well known for years (1)(2)(3)(4)(5). Increasing body mass requires increased cardiac debi and vascular volume to supply metabolic demands (3,6,7). This may be partly due to the altered metabolic needs induced by increased body weight (8).Left ventricular hypertrophy (LVH) may cause diastolic and systolic heart failure; it is also an independent risk factor for cardiac arrhythmia, sudden death, myocardial ischemia, and heart failure (9). LVH in obese people is related to the severity of comorbidities, mainly hypertension. Although obesity itself is an independent risk factor for LVH in hypertensive patients, the roles of excess body weight and obesity in LVH in normotensive subjects are inconclusive (5, 10). In this article, we investigated the relationships of obesity and insulin resistance with LVH and diastolic function in nondiabetic, normotensive women who were followed up at our obesity outpatient clinic; the results were compared with those of normal women. MethodsThis study was conducted at our hospital with 81 obese, nondiabetic, normotensive female subjects (study group) and 36 healthy female controls (control group). All participants were informed about the survey and freely signed and dated the consent form. The protocol was approved by the Local Ethics Committee and was conducted in accordance with the Declaration of Helsinki.Patients were excluded if they had a history of ischemic heart disease, congestive heart failure, cardiac valve disease, liver or kidney disease, hypertension, cancer, adrenal disease (such as Conn's disease, pheochromocytoma, or Cushing's syndrome, which can cause secondary hypertension), diabetes mellitus, thyroid disease, glucose intolerance, malnutrition, or malabsorption.The age, weight, height, body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure, and heart rate of the subjects were recorded. Serum fasting blood glucose (FBG), Relationship of Left Ventricular Mass with BMI and Insulin Resistance in Normotensive Obese WomenObjective: Obesity is correlated with left ventricular mass (LVM) and insulin resistance (IR) and is an independent predictor of LVM in nondiabetic, nonhypertensive, obese people. Our aim was to investigate the relationship of body mass index (BMI) and IR with left venticular mass index (LVMI) in obese and nonobese, normotensive, nondiabetic women.Methods: 81 obese, normotensive, nondiabetic women and 36 healthy women of normal weight were included in the study. We compared the demographic features, biochemical values, insulin and HOMA-IR values, heart rate, blood pressure, and echocardiographic parameters of the obese and nonobese subjects. Results:The mean age was 39.3±11.2 years and the mean BMI was 39.5±5.7 kg/m 2 in the obese group; the mean age was 38.4±9.5 years and the mean BMI was 22.5±1.9 kg/m 2 in the control group. Hyperinsulinemia (19.3±10.4 µU/mL) and IR (HOMA-IR: 4.6±2.9) were correlated with obesity. Insulin levels and IR were...

show abstract

“…Sendo considerada como uma epidemia mundial, é caracterizada como uma condição complexa de ordem multifatorial [5]. Condição que leva ao surgimento ou acréscimo de doenças, estando a obesidade abdominal, intimamente relacionada com o aumento significativo de doenças cardiovasculares e de ordem metabólica, como a hipertensão, dislipidemia e hiperglicemia [7,8].…”

Section: Introductionunclassified

Risco cardiovascular, índices antropométricos e percepção de qualidade de vida em idosos

Couto

Santos

et al. 2017

Sci. Plena

View full text Add to dashboard Cite

O presente estudo teve como objetivo identificar à prevalência de risco cardiovascular de acordo com índices antropométricos e avaliar à qualidade de vida em idosas participantes de grupos comunitários de prática de atividade física. Trata-se de um estudo com delineamento transversal, com amostra por conveniência. A amostra foi constituída por 84 idosas com média de idade 66,66 ± 5,54 anos. Aplicou-se instrumento compilado a partir de questionários validados para o Brasil. Também coletou-se os dados de massa corporal, estatura e circunferências de cintura, quadril e abdômen. Foram analisadas as variáveis sociodemográficas, percepção de qualidade de vida, nível de atividade física e a avaliação dos índices antropométricos índice de massa corporal e relação cintura/quadril. Enquanto principais resultados, verifica-se que 64,6% dos idosos são ativos, à circunferência de cintura classifica 79,48% dos idosos como "risco" e não houve diferença entre a percepção de qualidade de vida e à exposição ao risco identificado pelos índices antropométricos (F(3,71)= 0,31; p= 0,82). Conclui-se que a circunferência de cintura foi o índice antropométrico que melhor estimou o risco do grupo e que a percepção de qualidade de vida independe da estimativa de risco a qual o sujeito está exposto.Palavras-chave: idoso, obesidade, qualidade de vidaThe present study aimed to identify the prevalence of cardiovascular risk according to anthropometric indices and to evaluate the quality of life in elderly women participating in community groups of physical activity practice. It is a cross-sectional study, with convenience sample. The sample consisted of 84 elderly women with a mean age of 66.66 ± 5.54 years. An instrument compiled from questionnaires validated for Brazil was applied. Data were also collected on body mass, height and circumferences of waist, hip and abdomen. sociodemographic variables, perception of quality of life, level of physical activity and evaluation of anthropometric indices, body mass index and waist / hip ratio were analyzed. The main results show that 64.6% of the elderly are active, waist circumference classifies 79.48% of the elderly as "risk" and there was no difference between the perception of quality of life and the risk exposure identified by the anthropometric index (F (3,71) = 0.31, p = 0.82). It was concluded that waist circumference was the anthropometric index that best estimated the risk of the group and that the perception of quality of life independent of the risk estimate to which the subject is exposed.Keywords: elderly, obesity, quality of life INTRODUÇÃOA transição demográfica (TD), caracterizada pelo aumento da expectativa de vida, redução da taxa de fecundidade e consequente aumento da proporção de idosos em relação aos mais jovens, tem se configurado como um fator preocupante entre os países desenvolvidos e em desenvolvimento [1]. Essa preocupação se dá devido às alterações que ocorrem na previdência social e no alto custo financeiro despendido na saúde especializada, tendo em vista que um idos...

show abstract

Impact of Obesity and Weight Loss on Cardiac Performance and Morphology in Adults

Cited by 219 publications

References 75 publications

Obesity paradox in heart failure: a heavy matter

Obesity paradox in heart failure: a heavy matter

Relationship of Left Ventricular Mass with BMI and Insulin Resistance in Normotensive Obese Women

Risco cardiovascular, índices antropométricos e percepção de qualidade de vida em idosos

Contact Info

Product

Resources

About