Impact of obesity on coronary artery calcification examined by electron beam computed tomographic scan

Hsu, Cheng Hsiung; Chang, Steve G.N.; Hwang, Kung‐Chang; Chou, Pesus

doi:10.1111/j.1463-1326.2006.00617.x

Cited by 8 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In keeping with our data presented here, some previous studies have demonstrated a positive association (11–15), whereas the majority have shown neutral (5,16–22) or negative (23) associations.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Fasting Glucose, Obesity, and Coronary Artery Calcification in Community-Based People Without Diabetes

et al. 2012

View full text Add to dashboard Cite

OBJECTIVEOur objective was to assess whether impaired fasting glucose (IFG) and obesity are independently related to coronary artery calcification (CAC) in a community-based population.RESEARCH DESIGN AND METHODSWe assessed CAC using multidetector computed tomography in 3,054 Framingham Heart Study participants (mean [SD] age was 50 [10] years, 49% were women, 29% had IFG, and 25% were obese) free from known vascular disease or diabetes. We tested the hypothesis that IFG (5.6–6.9 mmol/L) and obesity (BMI ≥30 kg/m2) were independently associated with high CAC (>90th percentile for age and sex) after adjusting for hypertension, lipids, smoking, and medication.RESULTSHigh CAC was significantly related to IFG in an age- and sex-adjusted model (odds ratio 1.4 [95% CI 1.1–1.7], P = 0.002; referent: normal fasting glucose) and after further adjustment for obesity (1.3 [1.0–1.6], P = 0.045). However, IFG was not associated with high CAC in multivariable-adjusted models before (1.2 [0.9–1.4], P = 0.20) or after adjustment for obesity. Obesity was associated with high CAC in age- and sex-adjusted models (1.6 [1.3–2.0], P < 0.001) and in multivariable models that included IFG (1.4 [1.1–1.7], P = 0.005). Multivariable-adjusted spline regression models suggested nonlinear relationships linking high CAC with BMI (J-shaped), waist circumference (J-shaped), and fasting glucose.CONCLUSIONSIn this community-based cohort, CAC was associated with obesity, but not IFG, after adjusting for important confounders. With the increasing worldwide prevalence of obesity and nondiabetic hyperglycemia, these data underscore the importance of obesity in the pathogenesis of CAC.

show abstract

Section: Discussionsupporting

confidence: 92%

“…Likewise, the cross-sectional data linking obesity to CAC have not been conclusive, with some studies showing positive relationships (11–15), whereas the majority have shown neutral or negative relationships (5,16–23). …”

mentioning

confidence: 99%

Fasting Glucose, Obesity, and Coronary Artery Calcification in Community-Based People Without Diabetes

et al. 2012

View full text Add to dashboard Cite

show abstract

“…16,17 In turn, the CAC burden is widely considered to be a marker of atherosclerosis and a risk factor for the development of future cardiac events. 18 Specifically, patients with CAC of 1–100, 101–300 and >300 HU were 3.6, 7.73 and 9.67 times more likely to suffer from a major cardiac event compared to patients with a CAC=0.…”

Section: Discussionmentioning

confidence: 99%

Subclinical coronary atherosclerosis identified by coronary computed tomographic angiography in asymptomatic morbidly obese patients

Lubanski¹,

Vanhecke²,

Chinnaiyan³

et al. 2010

Heart Int

View full text Add to dashboard Cite

Obesity is a common public health problem and obese individuals in particular have a disproportionate incidence of acute coronary events. This study was undertaken to identify coronary artery lesions as well as associated clinical features, risk factors and demographics in patients with a body mass index (BMI) >40 kg/m2 without known coronary artery disease (CAD). Morbidly obese subjects were prospectively recruited to undergo coronary computed tomographic angiography (CCTA) using a dual-source computed tomography (CT) system. CAD was defined as the presence of any atherosclerotic lesion in any one coronary artery segment. The presence, location, and severity of atherosclerosis were related to patient characteristics. Forty-one patients (28 women, mean age, 50.4±10.0 years, mean BMI, 43.8±4.8 kg/m2) served as the study population. Of these, 25 patients (61%) had at least one coronary stenosis. All but 2 patients within the CAD cohort had coronary artery calcium (CAC) scores >0, and most plaques identified (75.4%) were non-calcified. There was a predilection of calcified and non-calcified atherosclerosis involving the left anterior descending (LAD) coronary artery compared with other coronary segments. Univariate predictors of CAD included older age, dyslipidemia, and diabetes. In this preliminary study of young morbidly obese patients, CCTA detected a high prevalence of calcified and non-calcified CAD, although the later predominated.

show abstract

Current literature in diabetes

2007

Diabetes Metabolism Res

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

show abstract

Impact of obesity on coronary artery calcification examined by electron beam computed tomographic scan

Abstract: This study demonstrated that the obese BMI group has a higher mean of CAC scores than the healthy BMI group of middle-aged, asymptomatic, Chinese adults. The obese males have higher risk of developing high CAC scores, which might induce CVD.

Cited by 8 publications

References 25 publications

Fasting Glucose, Obesity, and Coronary Artery Calcification in Community-Based People Without Diabetes

Fasting Glucose, Obesity, and Coronary Artery Calcification in Community-Based People Without Diabetes

Subclinical coronary atherosclerosis identified by coronary computed tomographic angiography in asymptomatic morbidly obese patients

Current literature in diabetes

Contact Info

Product

Resources

About