Impact of obesity on endometrial blood flow in women without polycystic ovarian syndrome during intracytoplasmic sperm injection

Zeng, Xun; Pang, Houqing; Li, Xiaohong; Luo, Shan; Jin, Song; Li, Shangwei

doi:10.1186/1477-7827-11-57

Cited by 9 publications

(10 citation statements)

References 37 publications

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“…As a result, blood is forced through smaller distal spiral arteries, which would retain their muscular wall, resulting in increased flow turbulence, shear stress, and infarction in the intervillous space (45). Interestingly, endometrial and spiral artery blood flow is reduced in obese women before pregnancy (97). Furthermore, placentas from stillbirths of Ն20 wk of gestation having abnormal spiral artery modifications were associated with a greater incidence of maternal prepregnancy obesity and PE (4).…”

Section: Do Maternal Obesity and Related Metabolic Factors Adversely mentioning

confidence: 99%

Metabolic abnormalities and obesity’s impact on the risk for developing preeclampsia

Spradley

2017

American Journal of Physiology-Regulatory, Integrative and Comp

100

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Preeclampsia (PE), a hypertensive disorder of pregnancy, is increasing as a major contributor to perinatal and long-term morbidity of mother and offspring. PE is thought to originate from ischemic insults in the placenta driving the release of prohypertensive anti-angiogenic [soluble fms-like tyrosine kinase-1 (sFlt-1)] and proinflammatory [tumor necrosis factor-α (TNF-α)] factors into the maternal circulation. Whereas the increased incidence of PE is hypothesized to be largely due to the obesity pandemic, the mechanisms whereby obesity increases this risk are unknown. The maternal endothelium is targeted by placental and adipose tissue-derived factors like sFlt-1 and TNF-α that promote hypertension during pregnancy, resulting in vascular dysfunction and hypertension. Interestingly, not all obese pregnant women develop PE. Data suggest that obese pregnant women with the greatest metabolic abnormalities have the highest incidence of PE. Identifying obesity-related mechanisms driving hypertension in some obese pregnant women and pathways that protect normotensive obese pregnant women, may uncover novel protocols to treat PE. Metabolic abnormalities, such as increased circulating leptin, glucose, insulin, and lipids, are likely to increase the risk for PE in obese women. It is not only important to understand whether each of these metabolic factors contribute to the increased risk for PE in obesity, but also their cumulative effects. This is particularly relevant to obese pregnant women with gestational diabetes mellitus (GDM) where all of these factors are increased and the risk for PE is highest. It is speculated that these factors potentiate the anti-angiogenic and proinflammatory mechanisms of placental ischemia-induced vascular dysfunction thereby contributing to the increasing incidence of PE.

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Section: Do Maternal Obesity and Related Metabolic Factors Adversely mentioning

confidence: 99%

Metabolic abnormalities and obesity’s impact on the risk for developing preeclampsia

Spradley

2017

American Journal of Physiology-Regulatory, Integrative and Comp

100

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“…In contrast, some studies failed to show a relationship between obesity and IVF success. Although obesity caused increased gonadotropin doses, intrauterine insemination [20], IVF [21,22], and ICSI [23] success was not decreased. No relationship was established between BMI and anti-Müllerian hormone [24] or between BMI and AFC [25].…”

Section: Discussionmentioning

confidence: 94%

Do Bmı or Waıst-to-Hıp Ratıo Interfere wıth The Number of Oocytes Retrıeved ın IVF Cycles?

Güngör¹,

Korkmaz²,

Ozekinci³

et al. 2015

Int. J. Gynecol. Obstet. & Neona. Care

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The effect of obesity on ovarian response to ovulation induction and on in vitro fertilization (IVF) outcome is controversial. This controversy might stem from the fact that almost all studies on the subject use body mass index (BMI) for obesity measurement. We aimed to determine which obesity measure predicts the possible effect of obesity on ovarian response in IVF patients. In this retrospective study, patients who presented for IVF and underwent an antagonist protocol were included. Their histories and cycle properties were recorded, as well as their BMI and waist-tohip (W/H) ratios. A total of 35 patients were included. While normal BMI significantly lowered the gonadotropin dose, normal W/H ratio increased the antral follicle count (AFC). Both BMI and W/H ratio did not significantly affect either the number of oocytes retrieved or the metaphase II oocytes. Ovulation induction during IVF cycles can overcome the adverse effects of obesity on ovarian reserve. Large-sample-sized, well-designed studies must be performed to clarify the best obesity measurement method for infertility treatment and to determine the real effect of obesity on IVF success.

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“…In the final analysis, 105 eligible studies (19 prospective and 86 retrospective cohort studies) were included, involving more than 271,632 pregnant women (Figure 1). 14,15,28–130 The main characteristics of included studies were summarized in Table S1. In total, 100 studies reported the association between maternal BMI and CPR among pregnant women undergoing ART, among which 53 reported MR and 51 reported LBR (Table S1).…”

Section: Resultsmentioning

confidence: 99%

“…In total, 100 studies reported the association between maternal prepregnancy body weight and CPR after ART 14,15,28–55,58–80,82–117,119–122,124–130 . At per‐woman level, 54 studies, involving 109,688 pregnant women, showed an inverted J‐shaped relationship between maternal BMI and CPR ( P n < 0.01) 14,28–31,34–36,40,41,44,46,47,49,53,58,60,61,64–68,75,76,78,82,85,86,88–95,97,99,103–106,109,112–114,119,121,124,126–128,130 . Compared with the reference BMI value (21.75 kg/m 2 ), BMI > 22.5 kg/m 2 was associated with lower CPR (Figure 2a and Table 1).…”

Section: Resultsmentioning

confidence: 99%

Association between maternal prepregnancy body mass index and pregnancy outcomes following assisted reproductive technology: A systematic review and dose–response meta‐analysis

et al. 2021

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Summary This systematic review investigated dose–response relationship between maternal prepregnancy body mass index (BMI) and pregnancy outcomes following assisted reproductive technology, including clinical pregnancy rate (CPR), miscarriage rate (MR), and live birth rate (LBR). We searched four major databases and finally included 105 studies involving more than 271,632 pregnant women. We performed linear or nonlinear dose–response meta‐analyses using random effects models. At per‐woman level, pooling of unadjusted estimates shown an inverted J‐shaped relationship between maternal BMI and CPR; pooling of adjusted estimates showed a linear association, suggesting statistical association between higher maternal BMI and lower CPR (adjusted OR [aOR] for 5‐unit increase in BMI: 0.96, 95%CI: 0.94–0.98). At per‐cycle level, linear dose–response relationship was found between maternal BMI and CPR (crude relative risk, RR, [cRR] for 5‐unit increase in BMI 0.97, 0.96–0.98; aOR 0.96, 0.94–0.99). Linear dose–response relationship was established between maternal BMI and the outcomes of MR or LBR (higher BMI associated with higher MR [cRR 1.15, 1.08–1.22] and lower LBR [cRR 0.91, 0.88–0.94] at per‐woman level). Sensitivity analyses showed no significant changes. In conclusion, there is dose–response relationship between maternal BMI and pregnancy outcomes following assisted reproductive technology. Higher BMI values may suggest suboptimal pregnancy outcomes.

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Impact of obesity on endometrial blood flow in women without polycystic ovarian syndrome during intracytoplasmic sperm injection

Cited by 9 publications

References 37 publications

Metabolic abnormalities and obesity’s impact on the risk for developing preeclampsia

Metabolic abnormalities and obesity’s impact on the risk for developing preeclampsia

Do Bmı or Waıst-to-Hıp Ratıo Interfere wıth The Number of Oocytes Retrıeved ın IVF Cycles?

Association between maternal prepregnancy body mass index and pregnancy outcomes following assisted reproductive technology: A systematic review and dose–response meta‐analysis

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