Impact of Obstructive Sleep Apnea on Neurocognitive Function and Impact of Continuous Positive Air Pressure

Davies, Charles R.; Harrington, John

doi:10.1016/j.jsmc.2016.04.006

Cited by 58 publications

(40 citation statements)

References 81 publications

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“…Neurocognitive dysfunction has a major impact on the individuals' daily life and professional activities, especially with professional drivers. The last studies are consistent in supporting the presence of impaired attention, delayed visual and verbal memory, visuospatial skills, and impairment of some aspects of executive function and fine motor coordination (Davies & Harrington, 2016).…”

Section: Introductionsupporting

confidence: 63%

Influence of Obstructive Sleep Apnea Syndrome and Sleep Variables on Cognitive Performance and Psychological Distress in Severely Obese Patients

Ribeiro¹,

Carvalho²,

Carmo³

et al. 2017

RHS

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Section: Introductionsupporting

confidence: 63%

Influence of Obstructive Sleep Apnea Syndrome and Sleep Variables on Cognitive Performance and Psychological Distress in Severely Obese Patients

Ribeiro¹,

Carvalho²,

Carmo³

et al. 2017

RHS

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“…Obstructive sleep apnoea (OSA) is a highly prevalent clinical condition characterised by repeated episodes of upper airway obstruction during sleep, which imposes not only substantial cardiovascular and metabolic morbidity, but is also implicated in deleterious consequences on cognitive and behavioural functioning [1,2]. Evidence pointing to structural brain changes in neural sites underlying cognitive functioning may ultimately account to the neuropsychological impairments [3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Temporal trajectories of novel object recognition performance in mice exposed to intermittent hypoxia

et al. 2017

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Intermittent hypoxia is one of the major perturbations of sleep-disordered breathing and has been causally implicated in neurocognitive deficits. However, the reversibility of such deficits is unclear.Male C57BL/6J mice were exposed to either intermittent hypoxia or room air for 3-240 days, and then half were randomly selected and allowed to recover in normoxic conditions for the same duration of the previous exposure. A novel object recognition (NOR) test was performed.NOR performance was stable over time in room air. Intermittent hypoxia induced significant reductions in recognition index that progressed over the first 45 days and stabilised thereafter. Normoxic recovery of recognition index was essentially complete and indistinguishable from room air in mice exposed to shorter intermittent hypoxia times (<90 days). However, significant residual deficits emerged after normoxic recovery following prolonged intermittent hypoxia exposures (p<0.01). In addition, gradual attenuation of the magnitude of recovery in recognition index occurred with increasingly longer intermittent hypoxia exposures (MANOVA p<0.0001).Intermittent hypoxia during the resting period reduces NOR performance in a time-dependent fashion. Reversal of NOR performance deficits is unlikely after prolonged intermittent hypoxia duration. These findings suggest that early recognition of sleep apnoea and effective treatment are critical for restoration of the adverse cognitive effects of the disease.

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“…9 Neurocognitive processing speed is a measure of such psychomotor function, which has often been reported with tests of 2-hand coordination or reaction time tests. 10 When assessing neuropsychological decline in patients with OSA, a recent systematic review defines existing findings as imprecise, having unknown consistency of evidence from studies as well as evidence limited by the risk of bias. 11 Although it is well established that psychomotor speed assessed with the Stroop test 12,13 is impaired in OSA patients, more complex psychomotor performance measures are still not well established as being deteriorated in OSA.…”

Section: Introductionmentioning

confidence: 99%

<p>Psychomotor Performance in Patients with Obstructive Sleep Apnea Syndrome</p>

Kalcina¹,

Dodig²,

Pecotić³

et al. 2020

NSS

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Purpose: Determinants of obstructive sleep apnea (OSA) are hypoxemia and hypercapnia, as well as (micro) arousals from sleep, resulting in chronic sleep fragmentation, sleep deprivation, and excessive daytime sleepiness (EDS). All of the above-mentioned factors might contribute to psychomotor impairment seen in OSA patients. Additionally, this study aimed to assess the contribution of BMI, age, EDS assessed with Epworth sleepiness scale (ESS), and severity of OSA assessed with apnea-hypopnea index (AHI) to the reaction time on chronometric tests in OSA patients and controls. It is hypothesized that moderate and severe OSA have adverse effects on reaction time of perception to visual stimulus, of solving simple arithmetic operations, and of psychomotor limbs coordination assessed by chronometric psychodiagnostic test battery. Patients and Methods: This study was conducted on 206 male participants; 103 of them had moderate or severe OSA diagnosed by whole-night polysomnography/polygraphy. Control participants (N=103), matched to patients with OSA by age and BMI, had no reported OSA in their medical history, no increased risk for OSA, nor EDS. All participants were assessed with three chronometric psychodiagnostic tests, measuring the reaction time of perception to visual stimulus, of solving simple arithmetic operations, and of psychomotor limbs coordination. Results: Participants from the OSA group achieved impaired results compared to control participants in minimum single task solving time in speed of solving simple arithmetic operations (3±0.9 and 2.6±0.6, P<0.001), and in minimum solving time of a single task in complex psychomotor limbs coordination (0.69±0.2 and 0.61±0.1, P=0.007). Regression analysis revealed no significant contribution of daytime sleepiness to the results achieved in each of the tests. Conclusion: It is concluded that severe OSA impaired speed of perception, convergent, and operative thinking. Moreover, it is suggested that EDS did not contribute to poor psychomotor outcome in patients with OSA in this study, when age was controlled for.

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Impact of Obstructive Sleep Apnea on Neurocognitive Function and Impact of Continuous Positive Air Pressure

Cited by 58 publications

References 81 publications

Influence of Obstructive Sleep Apnea Syndrome and Sleep Variables on Cognitive Performance and Psychological Distress in Severely Obese Patients

Influence of Obstructive Sleep Apnea Syndrome and Sleep Variables on Cognitive Performance and Psychological Distress in Severely Obese Patients

Temporal trajectories of novel object recognition performance in mice exposed to intermittent hypoxia

<p>Psychomotor Performance in Patients with Obstructive Sleep Apnea Syndrome</p>

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