Impact of obstructive sleep apnoea on left ventricular mass and global function

Dursunoğlu, Dursun

doi:10.1183/09031936.05.00038804

Cited by 99 publications

(85 citation statements)

References 40 publications

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“…Some studies have described that OSAS is not an independent risk factor in the development of CV disorders [11][12][13]. However, other studies have stated that the rate of mortality is significantly higher in non-treated patients with AHI values over 20 [14], and the incidence of CVD in non-treated patients with moderate-severe OSAS is markedly increased compared to normal individuals or treated patients [15].…”

Section: Discussionmentioning

confidence: 99%

Early left ventricular functional alterations in patients with obstructive sleep apnea syndrome

Aslan

Deniz²,

Çaylı³

et al. 2013

Cardiol J

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Section: Discussionmentioning

confidence: 99%

Early left ventricular functional alterations in patients with obstructive sleep apnea syndrome

Aslan

Deniz²,

Çaylı³

et al. 2013

Cardiol J

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“…Previous investigators showed a correlation between OSA, LV mass, and LV global functions. 16 Others found a relationship between OSA, LV mass, and LV diastolic functions. 17 Obstructive sleep apnea might cause pulmonary hypertension and right-sided heart failure.…”

Section: Discussionmentioning

confidence: 99%

Biventricular Myocardial Performance Is Impaired in Proportion to Severity of Obstructive Sleep Apnea

Akyol¹,

Çörtük²,

Baykan³

et al. 2016

Texas Heart Institute Journal

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“…LV mass (measured by echocardiogram) has been shown to be higher in these patients 6,7 ; it may not be independently associated with OSA and may be more directly related to obesity or hypertension.…”

Section: S C I E N T I F I C I N V E S T I G At I O N Smentioning

confidence: 99%

Effect of CPAP on Cardiac Function in Minimally Symptomatic Patients with OSA: Results from a Subset of the MOSAIC Randomized Trial

Craig

Kylintireas

Kohler³

et al. 2015

Journal of Clinical Sleep Medicine

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Study Objectives: Minimally symptomatic obstructive sleep apnea (OSA) is highly prevalent, and the effects of continuous positive airway pressure (CPAP) on myocardial function in these patients are unknown. The MOSAIC randomized, controlled trial of CPAP for minimally symptomatic OSA assessed the effect of CPAP on myocardial function in a subset of patients. Methods: Two centers taking part in the MOSAIC trial randomized 238 patients in parallel to 6 months of CPAP (120) or standard care (118). Of these, 168 patients had echocardiograms, and 68 patients had a cardiac magnetic resonance scan (CMR). A larger group (314) from 4 centers had brain natriuretic peptide (BNP) measured. Results: Mean (SD) baseline oxygen desaturation index (ODI) and Epworth sleepiness score (ESS) were 13.5 (13.2), and 8.4 (4.0), respectively. CPAP signifi cantly reduced ESS and ODI. Baseline LV ejection fraction (LVEF) was well preserved (60.4%). CPAP had no signifi cant effect on echo-derived left atrial (LA) area (−1.0 cm 2 , 95% CI −2.6 to +0.6, p = 0. O bstructive sleep apnea (OSA) has the potential to be signifi cantly detrimental to cardiac function.1 Extreme sub-atmospheric pressure swings during apneic events can transiently reduce left ventricular (LV) emptying, and lead to increased left atrial (LA) and LV volumes, as well diastolic dysfunction. Over time, the LA may irreversibly enlarge, and patients with OSA have been shown to be more likely to develop atrial fi brillation (AF) as a possible consequence.2 In addition, it has been suggested that OSA can affect the aortic root, leading to increased rates of dilatation in some populations. 3-5Patients with OSA also have associated medical conditions such as diabetes, hypertension, and upper body obesity, which are recognized risk factors for cardiac disease. Many of these patients will have impaired diastolic function as a precursor to systolic dysfunction, and identifying this is important to prevent further functional decline. This is quantifi ed by measuring mitral blood fl ow (E/A ratio and deceleration times) and LA size (diameter or area) by echocardiography. In addition, Effect of CPAP on Cardiac Function in Minimally Symptomatic S C I E N T I F I C I N V E S T I G AT I O N SLV mass (measured by echocardiogram) has been shown to be higher in these patients 6,7 ; it may not be independently associated with OSA and may be more directly related to obesity or hypertension. 8Although echocardiograms are considered the gold standard for detecting diastolic dysfunction, cardiac magnetic BRIEF SUMMARY Current Knowledge/Study Rationale: The effect of CPAP therapy on cardiac function in patients with minimally symptomatic OSA is unknown. We used three methods (echocardiography, cardiac MR and BNP measurements) to assess cardiac function at baseline and after six months in patients randomized to CPAP or standard care. Study Impact: There was no improvement in cardiac function in any of the three measurements although baseline cardiac dysfunction was mild. This would suggest that co...

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Impact of obstructive sleep apnoea on left ventricular mass and global function

Cited by 99 publications

References 40 publications

Early left ventricular functional alterations in patients with obstructive sleep apnea syndrome

Early left ventricular functional alterations in patients with obstructive sleep apnea syndrome

Biventricular Myocardial Performance Is Impaired in Proportion to Severity of Obstructive Sleep Apnea

Effect of CPAP on Cardiac Function in Minimally Symptomatic Patients with OSA: Results from a Subset of the MOSAIC Randomized Trial

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