Impact of occult hepatitis B virus infection and prior hepatitis B virus infection on development of hepatocellular carcinoma in patients with liver cirrhosis due to hepatitis C virus

Adachi, Shigeru; Shibuya, Akitaka; Miura, Yuri; Takeuchi, Atsuko; Nakazawa, Takahide; Saigenji, Katsunori

doi:10.1080/00365520801935459

Cited by 45 publications

(56 citation statements)

References 36 publications

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“…For example, past infection of hepatitis B virus (HBV) has been indicated as a major risk factor for the development of HCC in patients with chronic hepatitis C virus (HCV) infection [13][14][15][16][17][18][19]. However, whether a similar risk exists in patients with PBC is unknown, and the answers are of particular importance for the management of PBC in HBV endemic areas such as China [20,21].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Risk Factors for Hepatocellular Carcinoma in Primary Biliary Cirrhosis

Rong

Wang

Bowlus

et al. 2015

Clinic Rev Allerg Immunol

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The incidence, risk factors, and clinical features of hepatocellular carcinoma (HCC) in primary biliary cirrhosis (PBC) have been a long-standing subject of interest. We took advantage of a large cohort of 1865 well-defined Chinese patients with PBC for whom follow-up was conducted for up to 20 years to study the incidence of HCC. Our goal was to address the incidence and prevalence of HCC in PBC and the risk factors, including hepatitis B virus (HBV) infection, and finally to compare the tumor characteristics of PBC-related HCC, including size, location, mortality, and long-term outcomes, to that of HBV-related HCC. In this cohort, HCC occurred in 70 of 1865 PBC patients with a prevalence of 3.75 % and an incidence of 0.66 cases per 100 patient-years. The 5- and 10-year cumulative incidences were 2.6 % (95 % confidence interval (CI) 1.8-3.4) and 8.9 % (95 % CI 5.5-12.3), respectively. Age >54 years (odds ratio [OR] = 5.5, 95 % CI 3.0-10.1, p = 0.001), male sex (OR = 2.2, 95 % CI 1.2-4.0, p = 0.001), co-existence of diabetes mellitus (DM) (OR = 3.1, 95 % CI 1.6-6.2, p = 0.002), and previous HBV infection (OR = 6.6, 95 % CI 3.7-11.9, p = 0.001) were independently associated with the development of HCC. The tumor size, number, location, and 5-year survival were not significantly different in PBC-related HCC compared to HBV-related HCC. Alpha-fetoprotein was elevated in only 20 % of the cases with PBC-related HCC. Although HCC was uncommon, occurring in fewer than 5 % of patients, the risk is significantly increased by age, sex, DM, and past HBV infection.

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Section: Introductionmentioning

confidence: 99%

Incidence and Risk Factors for Hepatocellular Carcinoma in Primary Biliary Cirrhosis

Rong

Wang

Bowlus

et al. 2015

Clinic Rev Allerg Immunol

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“…Patients who recover from self-limited acute hepatitis B infection without any clinical or biochemical signs of liver damage may develop OBI (4)(5)(6). Occult hepatitis B infection can lead to cirrhosis and fibrosis, and it is also an important risk factor for developing hepatocellular carcinoma in HCV-infected and HCV-negative patients with chronic liver disease (7,8).…”

Section: Introductionmentioning

confidence: 99%

Occult Hepatitis B Infection in Hepatitis C Patients with Hematological Disorders

Jonaidi-Jafari

Rezaee‐Zavareh

Tavallaei-Nosratabadi

et al. 2016

Jundishapur J Microbiol

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“…These women have to be considered as having chronic HBV infection. In addition to the aforementioned clinical implications, the relationship between anti-HBc positivity and hepatic and pancreatic carcinogenesis, should be mentioned, although is still not clear [32,33,34]. …”

Section: Discussionmentioning

confidence: 99%

Antibodies to Core Antigen of Hepatitis B Virus in Patients on Renal Replacement Therapy: Association with Demographic, Clinical and Laboratory Data

Grzegorzewska

Kurzawska-Firlej²,

Ratajewski³

et al. 2009

Nephron Clin Pract

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Background: Total antibodies to core antigen of hepatitis B virus (anti-HBc) are a marker for previous or current infection with hepatitis B virus (HBV). Our aim was to examine the prevalence and incidence of anti-HBc in relation to demographic, clinical and laboratory data of patients treated with intermittent hemodialysis (IHD). Methods: Predictors for anti-HBc positivity were evaluated in prevalence IHD patients with negative testing for surface antigen of HBV (HBsAg, n = 1,105) using the stepwise backward regression analysis. Patients starting IHD (n = 336) were introduced into the one-year prospective study evaluating seroconversion for anti-HBc. Results: Anti-HBc positivity (19.5% of all patients) was predicted by lack of vaccination against HBV with developed protective titer of antibodies to HBsAg (β = 0.592, p = 0.000), vintage of renal replacement therapy (RRT, β = 0.206, p = 0.000), history of hepatitis (β = 0.101, p = 0.000), and activity of alanine aminotransferase (β = 0.057, p = 0.037). In 85 prospective patients who finished first IHD year, seroconversion rate for anti-HBc was 1.23 episodes/100 patient-years. Conclusions: Lack of or not effective vaccination against HBV is the strongest predictor for prevalence of anti-HBc positivity in RRT patients. Periodical determination of anti-HBc, usually not required, may be helpful in evaluation of current epidemiological status and risk for further HBV infection in dialysis centers.

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Impact of occult hepatitis B virus infection and prior hepatitis B virus infection on development of hepatocellular carcinoma in patients with liver cirrhosis due to hepatitis C virus

Abstract: Serum anti-HBc, which indicates a previous HBV infection, has clinical significance in hepatocarcinogenesis in patients with HCV-related LC, but serum HBV DNA does not. Therefore, anti-HBc in serum is a significant predictor for HCC.

Cited by 45 publications

References 36 publications

Incidence and Risk Factors for Hepatocellular Carcinoma in Primary Biliary Cirrhosis

Incidence and Risk Factors for Hepatocellular Carcinoma in Primary Biliary Cirrhosis

Occult Hepatitis B Infection in Hepatitis C Patients with Hematological Disorders

Antibodies to Core Antigen of Hepatitis B Virus in Patients on Renal Replacement Therapy: Association with Demographic, Clinical and Laboratory Data

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