Impact of ocular symptoms on quality of life (QoL), work productivity and resource utilisation in allergic rhinitis patients – an observational, cross sectional study in four countries in Europe

Jc, Virchow; Kay, Stephen; Démoly, P.; Mullol, Joaquim; Canonica, Giorgio Walter; Higgins, Victoria

doi:10.3111/13696998.2011.576039

Cited by 65 publications

(73 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has already been found that ocular symptoms [19,20,21] and nasal congestion [22] are bothersome. However, this study showed that ocular symptoms, particularly eyelid edema, were more bothersome than nasal symptoms.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Allergic Rhinitis Symptoms on Quality of Life in Primary Care

Bousquet

Demoly

Devillier

et al. 2012

Int Arch Allergy Immunol

171

145

View full text Add to dashboard Cite

Background: Allergic rhinitis (AR) impairs quality of life (QoL), sleep and work. The Allergic Rhinitis and its Impact on Asthma (ARIA) classification is widely used, but the impact of the different symptoms on QoL is not clear. Objective: To describe characteristics of patients consulting in primary care for AR and to study the impact of AR symptoms and the ARIA classes on QoL. Methods: A multicenter prospective observational cross-sectional study assessed the visual analogue scale (VAS) in the management of AR in 990 patients consulting general practitioners for AR. Patients were classified according to the four classes of ARIA. VAS, Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and total symptom score (TSS) for nasal and non-nasal symptoms were evaluated. VAS and TSS measures were compared with RQLQ. Results: Mild intermittent rhinitis was diagnosed in 20% of patients, mild persistent rhinitis in 17%, moderate/severe intermittent rhinitis in 15% and moderate/severe persistent rhinitis in 48%. The presence of treatments did not affect VAS levels. Both severity and duration of rhinitis had an impact on QoL and VAS levels. Ocular symptoms (OR: 2.78, 95% CI: 1.965–3.939) including eyelid edema (OR: 2.07, 95% CI: 1.274–3.360) and asthenia (OR: 2.73, 95% CI: 1.922–3.877) had more impact on RQLQ than nasal obstruction (OR: 1.61, 95% CI: 1.078–2.405) and nasal pruritus (OR 1.45, 95% CI: 1.028–2.042). Sneezing and rhinorrhea did not impact RQLQ. Conclusions: This study confirmed that ocular symptoms and, to a lesser degree, nasal obstruction and pruritus have a significant impact on QoL.

show abstract

Section: Discussionmentioning

confidence: 99%

“…QoL impairment in AR has been associated with ocular symptoms [19,20,21] and nasal congestion [22]. However, there is no study on the global assessment of the impact of all individual nasal and ocular symptoms on QoL.…”

Section: Introductionmentioning

confidence: 99%

Impact of Allergic Rhinitis Symptoms on Quality of Life in Primary Care

Bousquet

Demoly

Devillier

et al. 2012

Int Arch Allergy Immunol

171

145

View full text Add to dashboard Cite

show abstract

“…13 As a matter of fact, the presence of conjunctivitis has been associated with an increased number of allergic rhinitis drug prescriptions. 24 A possible limitation of our study might be the sample size. However, the peculiarity of the study population (a homogeneous group of participants coming from the same small Region, sharing the same healthcare system, recruited by a small team of primary care physicians) and the presence of analogous numbers in similar surveys 25 may overcome such limitations.…”

Section: Main Findingsmentioning

confidence: 99%

Characteristics and predictors of allergic rhinitis undertreatment in primary care

Spinozzi

Murgia

Baldacci

et al. 2015

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Although allergic rhinitis is considered a raising medical problem in many countries it is often undertreated. The reasons for this phenomenon are not completely clear.The aim of this study is to evaluate factors associated with allergic rhinitis under-/no treatment. A sample of 518 allergic rhinitis patients recruited by their primary care physicians, as a part of the ARGA study, were invited to fill in a specific questionnaire regarding rhinitis symptoms, treatment, and rhinitis-related work/social disability. Chi-square test and logistic regression were performed to assess risk factors for allergic rhinitis under-/no treatment.Over one out of four patients had no treatment despite the symptoms and 13.5% were inadequately treated. Participants with asthma (OR 0.47, 95% CI 0.30-0.75) and conjunctivitis (0.44, 95% CI 0.27-0.71) were at lower risk of allergic rhinitis under-/no treatment: in asthmatics this reduction was related mainly to the concomitant asthma treatment (OR 0.19, 95% CI 0.10-0.37).Asthmatics with under-/not treated rhinitis had the highest prevalence of rhinitis-related quality of life impairment. Under-/no treatment for allergic rhinitis is still rather frequent despite the relevance of this disease. The simultaneous presence of asthma and an anti-asthmatic therapy are able to influence positively the treatment. Targeted interventions toward a better characterization and a tight follow-up of rhinitis patient without asthma are needed.

show abstract

“…Indeed, data from a recent observational cross-sectional study in France, Germany, Italy and Spain, which included 1,009 patient records, showed that in patients suffering from nasal symptoms, the presence of ocular symptoms reduced quality of life and work productivity, and increased healthcare resource utilization [15]. Based on this evidence, the relief of ocular symptoms remains a key unmet need [2,5,15]. …”

Section: Introductionmentioning

confidence: 99%

Should Intranasal Corticosteroids Be Used for the Treatment of Ocular Symptoms of Allergic Rhinoconjunctivitis? A Review of Their Efficacy and Safety Profile

Lightman

Scadding²

2012

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Allergic rhinoconjunctivitis (ARC) presents as nasal symptoms, eye watering and additional signs of ocular allergy (e.g. itchy/burning eyes). Intranasal corticosteroids (INSs) are the most effective treatment for the nasal symptoms of seasonal allergic rhinitis (SAR; based on 4 meta-analyses) and are considered first-line therapy when nasal congestion forms a substantial component of the patient’s rhinitis symptoms. Clinical trial evidence shows that INSs also provide some relief from ocular symptoms of SAR and seasonal ARC in adults. INSs probably alleviate eye watering, the main ocular symptom of SAR, by relieving nasal congestion. Other ocular symptoms also improve with INSs. The mechanism for this effect is unknown, but might relate to naso-ocular reflex reduction. There are limited data on ocular safety with INSs. However, the literature supports the use of INSs over several months as there appears to be no considerable increase in the risk of ocular hypertension or glaucoma.

show abstract

Impact of ocular symptoms on quality of life (QoL), work productivity and resource utilisation in allergic rhinitis patients – an observational, cross sectional study in four countries in Europe

Cited by 65 publications

References 18 publications

Impact of Allergic Rhinitis Symptoms on Quality of Life in Primary Care

Impact of Allergic Rhinitis Symptoms on Quality of Life in Primary Care

Characteristics and predictors of allergic rhinitis undertreatment in primary care

Should Intranasal Corticosteroids Be Used for the Treatment of Ocular Symptoms of Allergic Rhinoconjunctivitis? A Review of Their Efficacy and Safety Profile

Contact Info

Product

Resources

About