The neutronic properties of UO2-BeO fuel with various claddings are investigated through the Monte Carlo methods and the Linear Reactivity Model. A second order polynomial function is suggested to describe the relationship between the difference of the reactivity at the End of Cycle and the two factors, the uranium enrichment and the volume content of BeO in the UO2-BeO fuel. The uranium enrichment is determined to ensure the cycle length for each BeO fraction with the zircaloy, FeCrAl, and SiC claddings. Similar neutronic properties are observed between the zircaloy and SiC claddings for a given BeO fraction, including the infinity multiplication factor, the gas release, the power distribution, and the isotopic concentrations. An important feature of the UO2-BeO fuel is the production of 4 He, which is significant compared with the current UO2 fuel. Less production rates of xenon and krypton are found in the case of UO2-BeO-FeCrAl fuel-cladding system, while those in the UO2-BeO-zircaloy and UO2-BeO-SiC systems are quite similar to the current UO2-zircaloy system. The power distribution in an assembly or in a fuel pellet is flatter for the higher BeO fraction with the same cladding. Higher peak power in a fuel assembly is found with the FeCrAl cladding than that with the other two claddings, while the radial power distribution is quite similar for the three claddings.